Results 261 to 270 of about 260,886 (316)
Some of the next articles are maybe not open access.
Onkologische Welt, 2023
Nach Daten der Studie FLAURA2 zeigt Osimertinib plus Chemotherapie in der Behandlung des nicht-kleinzelligen Lungenkarzinoms (NSCLC) einen statistisch signifikanten Vorteil beim progressionsfreien Überleben (PFS) im Vergleich zu Osimertinib allein. Studienleiter Dr. Pasi Jänne, Boston (USA), stellte die Ergebnisse der Studie vor.
openaire +1 more source
Nach Daten der Studie FLAURA2 zeigt Osimertinib plus Chemotherapie in der Behandlung des nicht-kleinzelligen Lungenkarzinoms (NSCLC) einen statistisch signifikanten Vorteil beim progressionsfreien Überleben (PFS) im Vergleich zu Osimertinib allein. Studienleiter Dr. Pasi Jänne, Boston (USA), stellte die Ergebnisse der Studie vor.
openaire +1 more source
Cemiplimab (Libtayo) for NSCLC
The Medical Letter on Drugs and Therapeutics, 2023The FDA has approved cemiplimab-rwlc (Libtayo – Regeneron), an immune checkpoint inhibitor, for use in combination with platinum-based chemotherapy for first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in adults with no epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), or ROS1 aberrations
openaire +2 more sources
Capmatinib (Tabrecta) for NSCLC
The Medical Letter on Drugs and Therapeutics, 2023The FDA has granted regular approval to the oral kinase inhibitor capmatinib (Tabrecta – Novartis) for treatment of metastatic non-small cell lung cancer (NSCLC) in adults whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping. MET exon 14 skipping mutations occur in 3-4% of NSCLC cases.
openaire +2 more sources
Applications of genomics in NSCLC
Lung Cancer, 2005Cisplatin-based chemotherapy has long been the cornerstone of non-small cell lung cancer (NSCLC) management. However, median survival rarely exceeds 1 year. The identification of molecular markers can help to predict response, leading to a broad implementation of the new concept of customized chemotherapy.
ROSELL R +9 more
openaire +4 more sources
Sotorasib (Lumakras) for NSCLC
The Medical Letter on Drugs and Therapeutics, 2023Sotorasib (Lumakras — Amgen), an oral KRAS inhibitor, has received accelerated approval by the FDA for treatment of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) in adults who received at least one prior systemic therapy.
openaire +2 more sources
Lung Cancer, 2004
The prognosis of bronchogenic carcinoma in stage III N2 is poor. Five-year survival ranges between 0 and 5%. Lymph-node involvement itself still is the main prognostic factor. Complete lymphadenectomy improves long-term survival in contrast to lymph-node sampling.
Godehard, Friedel +4 more
openaire +2 more sources
The prognosis of bronchogenic carcinoma in stage III N2 is poor. Five-year survival ranges between 0 and 5%. Lymph-node involvement itself still is the main prognostic factor. Complete lymphadenectomy improves long-term survival in contrast to lymph-node sampling.
Godehard, Friedel +4 more
openaire +2 more sources
A review of Osimertinib in NSCLC and pharmacist role in NSCLC patient care
Journal of Oncology Pharmacy Practice, 2020Lung cancer is a complex, genetically heterogeneous disease. It is the most common cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents the majority of the diagnosed lung cancer cases. Osimertinib is a new treatment option that demonstrated a superior efficacy over standard epidermal growth factor receptor tyrosine ...
Osama M Al-Quteimat, Amer M Amer
openaire +2 more sources
Assessing Toripalimab in NSCLC
Cancer Discovery, 2022Abstract According to CHOICE-01, a phase III trial in China, the PD-1 inhibitor toripalimab plus chemotherapy improves progression-free survival in patients with untreated non–small cell lung cancer lacking actionable mutations. The findings boost combination chemo–immunotherapy, rather than chemotherapy alone, as the new standard for ...
openaire +2 more sources
Multimodality Therapy for NSCLC
2016The standard therapy for patients with unrespectable stage III non-small-cell lung cancer (NSCLC) is the combination of chemotherapy and radiotherapy. Although the concurrent use of both treatment modalities has been shown to be superior to sequential therapy, the role for additional chemotherapy, either as induction or as consolidation, remains ...
Lingling, Du +2 more
openaire +2 more sources