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Therapeutic Applications of Interface-Mimicking Peptides for Targeting the SARS-CoV-2 NSP12-NSP8 RdRp Complex

Molecular Therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication depends on the NSP12-NSP8-NSP7 complex, which plays a critical role in enhancing RNA-dependent RNA polymerase (RdRp) activity. NSP8 is particularly essential, stabilizing the RdRp complex and supporting viral replication across diverse variants. To disrupt this crucial interaction,
Young Ki Choi
exaly   +4 more sources

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SARS‐CoV‐2 NSP12 utilizes various host splicing factors for replication and splicing regulation

Journal of Medical Virology
Abstract The RNA‐dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of RNA viruses. Although the RdRps of lethal human coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), SARS‐CoV, and Middle East respiratory syndrome coronavirus (MERS‐CoV) have been extensively studied ...
Li Yang, Xiao‐Tao Zeng, Rong‐Hua Luo, Si‐Xue Ren, Lin‐Lin Liang, Qiu‐Xia Huang, Ying Tang, Hong Fan, Hai‐Yan Ren, Wan‐Jiang Zhang, Yong‐Tang Zheng, Wei Cheng   +11 more
openaire   +2 more sources

Development and Characterization of a New Monoclonal Antibody Against SARS-CoV-2 NSP12 (RdRp)

Journal of Medical Virology, 2023
Shou-Jiang Gao, Haitao Guo, Simon Cao
exaly  

Targeting SARS-CoV-2 Nsp12/Nsp8 Interaction Interface With Approved and Investigational Drugs: An in Silico Structure-Based Approach

Journal of Biomolecular Structure and Dynamics, 2022
Tuğba Gül İnci, Osman Mutluhan Uğurel, Erennur Uğurel   +2 more
exaly  

SARS-CoV-2 and SARS-CoV: Virtual Screening of Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12)

Journal of Medical Virology, 2021
Xu Jia, Tai Yang
exaly  

Drug repositioning to identify SARS-CoV-2 Nsp12/Nsp8 interaction interface inhibitors.

2020
İnci, Tuğba Gül, ATA, OĞUZ, SARIYER, EMRAH, MUTLU, ÖZAL, UĞUREL, OSMAN MUTLUHAN, BALIK, DİLEK, Uğurel, Erennur, KOÇER, SİNEM   +7 more
openaire   +4 more sources

Vitamin B12 May Inhibit RNA-Dependent-RNA Polymerase Activity of nsp12 From the SARS-CoV-2 Virus

IUBMB Life, 2020
Naveen Narayanan, Deepak T. Nair
exaly  

Structural Elucidation of SARS-CoV-2 Vital Proteins: Computational Methods Reveal Potential Drug Candidates Against Main Protease, Nsp12 Polymerase and Nsp13 Helicase

Journal of Pharmaceutical Analysis, 2020
Muhammad Usman Mirza, Matheus Froeyen
exaly  

Recombinant SARS-CoV nsp12 and the use of thereof and the method for producing it

2011
OH JONG WON, AHN DAE GYUN
openaire   +2 more sources

Point Mutations at Specific Sites of the nsp12–nsp8 Interface Dramatically Affect the RNA Polymerization Activity of SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America
Diego Ferrero, Núria Verdaguer, Esteban Domingo Solans   +2 more
exaly