Results 161 to 170 of about 40,674 (185)

SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist.

Journal of Virology, 2021
Previous studies investigated the interaction between SARS-CoV-2 viral proteins and interferon signaling and proposed that several SARS-CoV-2 viral proteins, including NSP12, could suppress IFN-β activation. However, most of these results were generated from IFN-β promoter luciferase reporter assay and have not been validated functionally.
Pei-Hui Wang, Yuchen Xia, Kaitao Zhao
exaly   +4 more sources

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Typing of alpha and beta coronaviruses by DNA barcoding of NSP12 gene

Journal of Medical Virology, 2022
AbstractSince the spread of the COVID‐19 pandemic, the world paid attention to coronaviruses (CoVs) evolution and their diverged lineages because many researches studies supposed that the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is evolutionarily developed from a lineage of bats CoVs.
Waleed A. Nemr, Nashwa K. Radwan
openaire   +2 more sources

SARS-CoV-2 nsp12 Attenuates Type I Interferon Production by Inhibiting IRF3 Nuclear Translocation [PDF]

Cellular and Molecular Immunology, 2021
Abstract SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor inducer of type I interferon (IFN). Here, we report that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host antiviral responses.
Jianwei Wang, Zhuo Zhou, Zichun Xiang
exaly   +3 more sources

Plant-Derived Exosomal microRNAs Inhibit Lung Inflammation Induced by Exosomes SARS-CoV-2 Nsp12 [PDF]

Molecular Therapy, 2021
Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered exosomes released from the lung epithelial cells exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp12 and Nsp13 (exosomesNsp12Nsp13).
Anil Kumar, Xiang Yang Zhang, Shao-Yu Chen   +2 more
exaly   +3 more sources

Development and characterization of a new monoclonal antibody against SARS‐CoV‐2 NSP12 (RdRp)

Journal of Medical Virology, 2022
Abstract SARS‐CoV‐2 NSP12, the viral RNA‐dependent RNA polymerase (RdRp), is required for viral replication and is a therapeutic target to treat COVID‐19. To facilitate research on SARS‐CoV‐2 NSP12 protein, we developed a rat monoclonal antibody (CM12.1) against the NSP12 N‐terminus that can facilitate functional studies ...
Wen Meng, Siying Guo, Simon Cao, Masahiro Shuda, Lindsey R. Robinson‐McCarthy, Kevin R. McCarthy, Yoko Shuda, Alberto E. Paniz Mondolfi, Clare Bryce, Zachary Grimes, Emilia M. Sordillo, Carlos Cordon‐Cardo, Pengfei Li, Hu Zhang, Stanley Perlman, Haitao Guo, Shou‐Jiang Gao, Yuan Chang, Patrick S. Moore   +18 more
openaire   +2 more sources

Lung-Targeted Delivery of nsp12 siRNAs Restores Host Type I Interferon Responses

Chemical Engineering Journal
Peng Hou, Qi Yang, Daxu Li
exaly   +2 more sources

In-Silico Analysis to Identify Potential Inhibitors Against the Protein NSP12 of SARS-CoV-2

International Journal of Quantitative Structure-Property Relationships, 2021
In this pandemic condition, a drug candidate which is effective against COVID-19 is very much desired. This study initiates an in silico analysis to screen small molecules such as phytochemicals, drug metabolites, and natural metabolites against Nsp12 (a catalytic unit for RNA transcription and replication).
Hima Vyshnavi, null Gayathri S. S., Shahanas Naisam, Suvanish Kumar, Nidhin Sreekumar   +4 more
openaire   +1 more source

Erratum: The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

2011
The authors wish to apologise for an error in the concentration of tetracycline used to induce SARS-coronavirus nsp12 expression in E. coli. In the second paragraph of Materials and Methods, the sentence: “Subsequently, the cells were slowly cooled to room temperature, tetracycline was added to a final concentration of 200 μg/ml and the cells were ...
Snijder, Eric J., Arnold, Jamie J., van den Worm, Sjoerd H. E. , te Velthuis, Aartjan J. W., Cameron, Craig E.   +4 more
openaire   +1 more source

SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption

2023
Summary SARS-CoV-2 emerged into the human population in late 2019 and human to human transmission has dominated the evolutionary landscape and driven the selection of different lineages. The first major change that resulted in increased transmission was the D614G substitution in the spike protein. This was accompanied
Muhannad Alruwaili, Stuart Armstrong, Tessa Prince, Maximilian Erdmann, David A. Matthews, Andrew Davidson, Waleed Aljabr, Julian A. Hiscox   +7 more
openaire   +1 more source

PRRSV Nsp12 targets PSMA2 to suppress host proteasome activity and promote viral survival

Veterinary Microbiology
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the global swine industry, employing complex mechanisms to interact with the host and evade host immune responses. The ubiquitin-proteasome system (UPS) is central to host antiviral innate immunity, yet its interplay with PRRSV remains poorly understood.
Wei, Li, Danjiao, Yang, Ruiqing, Wang, Lan, Lan, Xinxin, Qiu, Xinglong, Wang   +5 more
openaire   +2 more sources