Results 141 to 150 of about 38,894 (153)

SARS‐CoV‐2 NSP12 utilizes various host splicing factors for replication and splicing regulation

Journal of Medical Virology
Abstract The RNA‐dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of RNA viruses. Although the RdRps of lethal human coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), SARS‐CoV, and Middle East respiratory syndrome coronavirus (MERS‐CoV) have been extensively studied ...
Li Yang, Xiao‐Tao Zeng, Rong‐Hua Luo, Si‐Xue Ren, Lin‐Lin Liang, Qiu‐Xia Huang, Ying Tang, Hong Fan, Hai‐Yan Ren, Wan‐Jiang Zhang, Yong‐Tang Zheng, Wei Cheng   +11 more
openaire   +2 more sources

Development and characterization of a new monoclonal antibody against SARS‐CoV‐2 NSP12 (RdRp)

Journal of Medical Virology, 2023
Zachary Grimes, Wen Meng, Simon Cao
exaly  

Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses

Frontiers in Immunology, 2023
Tim Westphal, Maria Mader, Sophia Schulte   +2 more
exaly  

Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach

Journal of Biomolecular Structure and Dynamics, 2022
Özal Mutlu, Osman Mutluhan Ugurel, Emrah Sariyer   +2 more
exaly  

SARS‐CoV‐2 and SARS‐CoV: Virtual screening of potential inhibitors targeting RNA‐dependent RNA polymerase activity (NSP12)

Journal of Medical Virology, 2021
Xinhe Huang, Xu Jia, Tai Yang
exaly  

Drug repositioning to identify SARS-CoV-2 Nsp12/Nsp8 interaction interface inhibitors.

2020
SARIYER, EMRAH, KOÇER, SİNEM, BALIK, DİLEK, Uğurel, Erennur, İnci, Tuğba Gül, ATA, OĞUZ, UĞUREL, OSMAN MUTLUHAN, MUTLU, ÖZAL   +7 more
openaire   +4 more sources

Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 virus

IUBMB Life, 2020
Naveen Narayanan, Deepak T Nair
exaly  

Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase

Journal of Pharmaceutical Analysis, 2020
Muhammad Usman Mírzá, Matheus Froeyen
exaly  

Point mutations at specific sites of the nsp12–nsp8 interface dramatically affect the RNA polymerization activity of SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America
Diego S Ferrero, Brenda Martinez-Gonzalez, Celia Perales   +2 more
exaly  

Identification of new antigenic epitopes of porcine reproductive and respiratory syndrome virus nsp12 protein using monoclonal antibodies

International Journal of Biological Macromolecules
Yifeng Jiang
exaly