Results 131 to 140 of about 38,894 (153)

UNICOR-v, a Pan-Coronavirus Subunit Vaccine, Demonstrates Immunogenicity and Efficacy Against MERS-CoV Infection. [PDF]

Vaccines (Basel)
Cole ME, Jossi S, Dillen C, Fanaroff R, Frieman M, Pleguezuelos O.   +5 more
europepmc   +1 more source

CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB. [PDF]

Virol Sin
Yang L, Zeng XT, Luo RH, Tang Y, Ren SX, Long XY, Fu XH, Zhang WJ, Ren HY, Zheng YT, Cheng W.   +10 more
europepmc   +1 more source

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Typing of alpha and beta coronaviruses by DNA barcoding of NSP12 gene

Journal of Medical Virology, 2022
AbstractSince the spread of the COVID‐19 pandemic, the world paid attention to coronaviruses (CoVs) evolution and their diverged lineages because many researches studies supposed that the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is evolutionarily developed from a lineage of bats CoVs.
Waleed A. Nemr, Nashwa K. Radwan
openaire   +2 more sources

Development and characterization of a new monoclonal antibody against SARS‐CoV‐2 NSP12 (RdRp)

Journal of Medical Virology, 2022
Abstract SARS‐CoV‐2 NSP12, the viral RNA‐dependent RNA polymerase (RdRp), is required for viral replication and is a therapeutic target to treat COVID‐19. To facilitate research on SARS‐CoV‐2 NSP12 protein, we developed a rat monoclonal antibody (CM12.1) against the NSP12 N‐terminus that can facilitate functional studies ...
Wen Meng, Siying Guo, Simon Cao, Masahiro Shuda, Lindsey R. Robinson‐McCarthy, Kevin R. McCarthy, Yoko Shuda, Alberto E. Paniz Mondolfi, Clare Bryce, Zachary Grimes, Emilia M. Sordillo, Carlos Cordon‐Cardo, Pengfei Li, Hu Zhang, Stanley Perlman, Haitao Guo, Shou‐Jiang Gao, Yuan Chang, Patrick S. Moore   +18 more
openaire   +2 more sources

In-Silico Analysis to Identify Potential Inhibitors Against the Protein NSP12 of SARS-CoV-2

International Journal of Quantitative Structure-Property Relationships, 2021
In this pandemic condition, a drug candidate which is effective against COVID-19 is very much desired. This study initiates an in silico analysis to screen small molecules such as phytochemicals, drug metabolites, and natural metabolites against Nsp12 (a catalytic unit for RNA transcription and replication).
Hima Vyshnavi, null Gayathri S. S., Shahanas Naisam, Suvanish Kumar, Nidhin Sreekumar   +4 more
openaire   +1 more source

PRRSV Nsp12 targets PSMA2 to suppress host proteasome activity and promote viral survival

Veterinary Microbiology
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the global swine industry, employing complex mechanisms to interact with the host and evade host immune responses. The ubiquitin-proteasome system (UPS) is central to host antiviral innate immunity, yet its interplay with PRRSV remains poorly understood.
Wei, Li, Danjiao, Yang, Ruiqing, Wang, Lan, Lan, Xinxin, Qiu, Xinglong, Wang   +5 more
openaire   +2 more sources

SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption

2023
Summary SARS-CoV-2 emerged into the human population in late 2019 and human to human transmission has dominated the evolutionary landscape and driven the selection of different lineages. The first major change that resulted in increased transmission was the D614G substitution in the spike protein. This was accompanied
Muhannad Alruwaili, Stuart Armstrong, Tessa Prince, Maximilian Erdmann, David A. Matthews, Andrew Davidson, Waleed Aljabr, Julian A. Hiscox   +7 more
openaire   +1 more source