Results 121 to 130 of about 40,674 (185)

The impact of remdesivir on SARS-CoV-2 evolution in vivo

JCI Insight
The impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo has remained unclear. In this single-center, retrospective cohort study, we assessed SARS-CoV-2 diversification and diversity over time in a cohort of hospitalized patients who did or
Ted Ling-Hu, Lacy M. Simons, Estefany Rios-Guzman, Alexandre Machado Carvalho, Maria Francesca R. Agnes, Arghavan Alisoltanidehkordi, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist   +8 more
doaj   +1 more source

RNF187 inhibits porcine reproductive and respiratory syndrome virus replication by recruiting the autophagy receptor NDP52 to degrade nsp12. [PDF]

Vet Res
Wang Q, Zheng G, Tian T, Chen A, Zhang G, Wang H.   +5 more
europepmc   +1 more source

Development and Application of a Dual-Fluorescent Reporter Assay for Feline Infectious Peritonitis Virus RNA-Dependent RNA Polymerase Inhibitor Screening. [PDF]

Int J Mol Sci
Semkum P, Lueangaramkul V, Jiwattanasap S, Mana N, Phetcharat N, Lekcharoensuk P, Theerawatanasirikul S.   +6 more
europepmc   +1 more source

GTPase domain of porcine Mx1 protein interacts with the N protein of porcine deltacoronavirus to inhibit viral replication. [PDF]

J Gen Virol
Shangguan H, Wu J, Li M, Ji Z, Wang Y, Zhang C, Wang H, Zhong D, Zhou Z, Zhang X, Shi D, Shi H, Guo L, Feng L, Chen J.   +14 more
europepmc   +1 more source

HPLC-HRMS/MS Characterization, Molecular Docking, and Comparative Genotoxicity of Free and Liposome-Encapsulated <i>Aesculus hippocastanum</i> Seed Extract. [PDF]

Int J Mol Sci
Andonova-Lilova B, Staleva P, Petkova Z, Mateev E, Zagorcheva T, Milkova V, Gyurova A, Martinov P, Rashev V, Vilhelmova-Ilieva N.   +9 more
europepmc   +1 more source

Biochemical insights into SARS-CoV replication

, 2014
Mon travail de thèse s'est focalisé sur la machinerie enzymatique impliquée dans la réplication du génome ARN du Syndrome Respiratoire Aigu Sévère-Coronavirus (SRAS-CoV). J'ai montré in vitro que l'activité ARN polymérase ARN-dépendante (RdRp) portée par
Subissi, Lorenzo
core  

Mechanistic insights into viral-host interactions during transcription. [PDF]

Biophys Rep
Huang Z, Peng T, Li Z, Zhu G, Zhu Z.
europepmc   +1 more source

La mutation P323L de nsp12 de SARS-CoV-2est-elle un marqueur d’espèce hôte?

International audienceThe SARS-CoV-2 replication and transcription complex (RTC) provides RNA-dependent RNA polymerase (RdRp) activity. In its minimal composition, it consists of ‘non-structural proteins’, including nsp12 in complex with its protein ...
Falcou, Camille, Lo-Belo, Léa, Eydoux, Cécilia, Snijder, Eric, Canard, Bruno   +4 more
core   +1 more source

Evolutionary inferences from the analysis of mutation dynamics in the SARS-CoV-2 replication-transcription complex. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Palyanov AY, Devyaterikov AP, Palyanova NV, Shestopalov AM.   +3 more
europepmc   +1 more source

Porcine Mx1 protein inhibits porcine deltacoronavirus replication in vitro by disturbing the N-Nsp12 interaction

Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen with significant economic impact and potential zoonotic risk. The interplay between PDCoV and host innate immunity, particularly involving interferon-stimulated genes (ISGs), remains incompletely understood.
openaire   +1 more source