Results 111 to 120 of about 40,674 (185)

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

mBio, 2018
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity.
Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison   +16 more
doaj   +1 more source

Characteristics of SARS-CoV-2 Omicron BA.5 variants in Shanghai after ending the zero-COVID policy in December 2022: a clinical and genomic analysis

Frontiers in Microbiology
IntroductionAn unprecedented surge of Omicron infections appeared nationwide in China in December 2022 after the adjustment of the COVID-19 response policy.
Pengcheng Liu, Jiehao Cai, He Tian, Jingjing Li, Lijuan Lu, Menghua Xu, Xunhua Zhu, Xiaomin Fu, Xiangshi Wang, Huaqing Zhong, Ran Jia, Yanling Ge, Yanfeng Zhu, Mei Zeng, Jin Xu, Jin Xu   +15 more
doaj   +1 more source

Structural basis for RNA replication by the SARS-CoV-2 polymerase

, 2020
Cryo-EM structures of the SARS-CoV-2 RNA polymerase in complexes with RNA, before and after RNA translocation, reveals structural rearrangements that the RNA-dependent RNA polymerase (RdRp) nsp12 and its co-factors (nsp7 and nsp8) undergo to accommodate ...
Wang, Quan, Gao, Hailong, Lou, Zhiyong, Yang, Xiaobao, Yan, Liming, Yang, Xiuna, Xu, Wenqing, Rao, Zihe, Wang, Haofeng, Ge, Ji, Sun, Qianqian, Zhu, Yan, Liu, Qiaojie, Jiang, Biao, Mu, An, Yang, Haitao, Gao, Yan, Gong, Peng, Guddat, Luke W., Ji, Wenxin, Liu, Fengjiang, Liu, Zhijie, Zhu, Chen, Fang, Xiang, Huang, Yucen, Wu, Jiqin   +25 more
core   +1 more source

Direct Detection of Viral Infections from Swab Samples by Probe‐Gated Silica Nanoparticle‐Based Lateral Flow Assay

ChemistryOpen
Point‐of‐care diagnosis is crucial to control the spreading of viral infections. Here, universal‐modifiable probe‐gated silica nanoparticles (SNPs) based lateral flow assay (LFA) is developed in the interest of the rapid and early detection of viral ...
Dilara Buse Durdabak, Soner Dogan, Serap Demir Tekol, Caner Celik, Veli Cengiz Ozalp, Bilge Guvenc Tuna   +5 more
doaj   +1 more source

SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12

Journal of Cell Biology
β-coronavirus rearranges the host cellular membranes to form double-membrane vesicles (DMVs) via NSP3/4, which anchor replication–transcription complexes (RTCs), thereby constituting the replication organelles (ROs). However, the impact of specific domains within NSP3/4 on DMV formation and RO assembly remains largely unknown.
Jinping Yang, Buyun Tian, Pei Wang, Rongrong Chen, Ke Xiao, Xubing Long, Xinyue Zheng, Yun Zhu, Fei Sun, Yongxia Shi, Yaming Jiu, Wei Ji, Yanhong Xue, Tao Xu, Zonghong Li   +14 more
openaire   +2 more sources

Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections

Nature Communications
We investigated the impact of antiviral treatment on the emergence of SARS-CoV-2 resistance during persistent infections in immunocompromised patients (n = 15).
Mohammed Nooruzzaman, Katherine E. E. Johnson, Ruchi Rani, Eli J. Finkelsztein, Leonardo C. Caserta, Rosy P. Kodiyanplakkal, Wei Wang, Jingmei Hsu, Maria T. Salpietro, Stephanie Banakis, Joshua Albert, Lars F. Westblade, Claudio Zanettini, Luigi Marchionni, Rosemary Soave, Elodie Ghedin, Diego G. Diel, Mirella Salvatore   +17 more
doaj   +1 more source

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

, 2021
In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome.
Subissi L.
core  

[In Press] A biochemical and biophysical analysis of the interaction of nsp9 with nsp12 from SARS-CoV-2 : implications for future drug discovery efforts

The ongoing global pandemic of the coronavirus 2019 (COVID-19) disease is caused by the virus SARS-CoV-2, with very few highly effective antiviral treatments currently available.
Cubeddu, Liza (R16726), Kwan, Ann, Artsimovitch, Irina, Gamsjaeger, Roland (R16936), Ataide, Sandro, El-Kamand, Serene (S33745), Baker, David L. (S37892), Wilkinson-White, Lorna, Wang, Bing, Allport, Thomas   +9 more
core   +1 more source

Transient complexes of the Nsp7, Nsp8 and Nsp12 in SARS-CoV-2 replication transcription complex [PDF]

Acta Crystallographica Section A Foundations and Advances, 2021
openaire   +1 more source

Is the P323L mutation in nsp12 of SARS-CoV-2 a host species marker?

The SARS-CoV-2 replication and transcription complex (RTC) provides RNA-dependent RNA polymerase (RdRp) activity. In its minimal composition, it consists of ‘non-structural proteins’, including nsp12 in complex with its protein cofactors: one copy of nsp7 and two of nsp8.
Falcou, Camille, Eydoux, Cécilia, Lo-Belo, Léa, Snijder, Eric, Canard, Bruno   +4 more
openaire   +1 more source