Results 101 to 110 of about 40,674 (185)

Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N,N′‐Diphenylurea

ChemMedChem, Volume 21, Issue 1, January 2026.
Inhibitors of SARS‐CoV‐2 RdRp activity based on N,N′‐diphenylurea scaffold have been identified. Several compounds exhibit residual activity (RA) below 50% in an enzymatic assay (at 10 µM concentration) and improved aqueous solubility compared to the previously reported series of inhibitors.
Artem Chayka, Matěj Danda, Alžběta Dostálková, Vojtěch Spiwok, Lamija Zijadic, Anna Klimešová, Marina Kapisheva, Michala Zgarbová, Jan Weber, Tomáš Ruml, Michaela Rumlová, Zlatko Janeba   +11 more
wiley   +1 more source

Twin engines of viral replication: Medicinal chemistry insights on SARS-CoV-2 nsp12 and nsp13

European Journal of Medicinal Chemistry
The SARS-CoV-2 pandemic highlighted the urgent need for antivirals targeting essential viral enzymes. Herein, we critically examine the current landscape of small molecule inhibitors targeting the highly conserved non-structural protein 12 (nsp12), the RNA-dependent RNA polymerase, and non-structural protein 13 (nsp13), the helicase, both critical for ...
Valentina Noemi Madia, Elisa Patacchini, Francesco Saccoliti, Laura Zarbo, Merve Arpacioglu, Roberta Costi, Roberto Di Santo   +6 more
openaire   +2 more sources

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase

, 2021
This entry contains screen datasets and raw images associated to the following manuscript: "Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase", Bertolin et al, Biochem Journal,
Agustina Bertolin (7557569), Jingkun Zeng (7558811), Florian Weissmann (7558691), John Diffley (7556252)   +3 more
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Comparison of the effect of nsp12 on nsp13 activity using RNA and DNA substrates.

, 2012
(A, B): Time course of (A) RNA (31/18-mer) and (B) DNA (31/18-mer) unwinding by GST-nsp13 alone (▪), or by GST-nsp13 with nsp12 (♦) or GST-nsp13 with Foot-and-Mouth Disease Virus RNA polymerase (▴).
Eric J. Snijder (45119), Aartjan J. W. te Velthuis (164518), Susan Weiss (164526), Kamalendra Singh (164534), Robert L. Eoff (129297), Adeyemi O. Adedeji (164507), Bruno Marchand (164513), Stefan G. Sarafianos (164540)   +7 more
core   +1 more source

Preferred binding modes of sennosides docked with four essential proteins of SARS-CoV-2 depicting 2D binding interactions.

, 2022
a) 3CLpro b) Helicase nsp13 c) Spike protein-ACE2 receptor complex docked at two different sites d) RdRp nsp12.
Afifa Navid (9920462), Naila Zaman (8230806), Ghulam Abbas (764241), Syed Sikander Azam (8230809), Rabia Farid (12872458), Nousheen Parvaiz (9992848)   +5 more
core   +1 more source

Remdesivir and Obeldesivir Retain Potent Antiviral Activity Against SARS-CoV-2 Omicron Variants

Viruses
As new SARS-CoV-2 variants continue to emerge, it is important to evaluate the potency of antiviral drugs to support their continued use. Remdesivir (RDV; VEKLURY®) an approved antiviral treatment for COVID-19, and obeldesivir (ODV) are inhibitors of the
Lauren Rodriguez, J. Lizbeth Reyes Zamora, Dong Han, Jasmine Moshiri, Nadine Peinovich, Clarissa Martinez, Pui Yan Ho, Jiani Li, Thomas Aeschbacher, Ross Martin, Andrew Pekosz, John P. Bilello, Jason K. Perry, Charlotte Hedskog   +13 more
doaj   +1 more source

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

, 2023
Summary How viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we show that the SARS-CoV-1 and −2 Ni dovirus R dRp- A ssociated N ucleotidyltransferase (NiRAN) domain on nsp12 uridylates the viral cofactor nsp8, forming a
Selisko, Barbara, Kazzi, Priscila El, Falcou, Camille, Rabah, Nadia, Feracci, Mikael, Shannon, Ashleigh, Yan, Xiaodong, Gauffre, Pierre, Moussa, Adel, Lin, Kai, Good, Steven, Sommadossi, Jean-Pierre, Zhu, Yingxiao, Noel, Mathieu, Alvarez, Karine, Eydoux, Cécilia, Debart, Françoise, Shi, Hui, Fattorini, Véronique, Canard, Bruno, Vasseur, Jean-Jacques, Sama, Bhawna, Decroly, Etienne, Guillemot, Jean-Claude, Ferron, François   +24 more
core   +1 more source

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins

mBio, 2017
Coronavirus (CoV) replication and transcription are carried out in close proximity to restructured endoplasmic reticulum (ER) membranes in replication/transcription complexes (RTC).
Jeremiah Athmer, Anthony R. Fehr, Matthew Grunewald, Everett Clinton Smith, Mark R. Denison, Stanley Perlman   +5 more
doaj   +1 more source

Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2

, 2020
A novel coronavirus (SARS-CoV-2) that is initially found to trigger human severe respiratory illness in Wuhan City of China in 2019, has killed 2,718 people in China by February 26, 2020, and which has been recognized as a public health emergency of international concern as well.
Zijing Ruan, Chao Liu, Yuting Guo, Zhenqing He, Xinhe Huang, Xu Jia, Tai Yang   +6 more
openaire   +2 more sources

Arterivirus NSP12 versus the coronavirus NSP16 29-O-methyltransferase: Comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins

, 2021
The 39-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a (putative) 29-O-methyltransferase (29-O-MTase), known as non structural protein (nsp) 16 in the ...
Lehmann K.C.
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