Results 81 to 90 of about 38,894 (153)

DataSheet1_Investigation of protein-protein interactions and hotspot region on the NSP7-NSP8 binding site in NSP12 of SARS-CoV-2.docx

Background: The RNA-dependent RNA polymerase (RdRp) complex, essential in viral transcription and replication, is a key target for antiviral therapeutics.
Emmanuel Duarte Barbosa (17806169), José Xavier Lima Neto (17806166), Marcelo Leite Lyra (17806178), Shopnil Akash (13866545), Hiba-Allah Nafidi (16453347), Katyanna Sales Bezerra (15952203), Yousef A. Bin Jardan (8535450), Umberto Laino Fulco (12645997), Mohammed Bourhia (11228466), Roniel Lima Araujo (17806172), Douglas Soares Galvão (17806175), Jonas Ivan Nobre Oliveira (15455466)   +11 more
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Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase

, 2021
This entry contains screen datasets and raw images associated to the following manuscript: "Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase", Bertolin et al, Biochem Journal,
Agustina Bertolin (7557569), Jingkun Zeng (7558811), Florian Weissmann (7558691), John Diffley (7556252)   +3 more
core  

Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex [PDF]

Coronaviruses contain one of the largest genomes among the RNA viruses, coding for 14–16 non-structural proteins (nsp) that are involved in proteolytic processing, genome replication and transcription, and four structural proteins that build the core of ...
Manelfi, Candida, Bjorn Windshügel, Paolo Malune, Angela Corona, Windshügel, Björn, Candida Manelfi, Nowotny, Marcin, Daniela Iaconis, Corona, Angela, Kuzikov, Maria, Malune, Paolo, Iaconis, Daniela, Gribbon, Philip, Enzo Tramontano, Beccari, Andrea, Wycisk, Krzysztof, Esposito, Francesca, Maria Kuzikov, Philip Gribbon, Andrea Zaliani, Andrea Beccari, Francesca Esposito, Marcin Nowotny, Zaliani, Andrea, Krzysztof Wycisk, Jeanette Reinshagen, Reinshagen, Jeanette, Tramontano, Enzo   +27 more
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SARS-CoV-2'nin NSP12 proteinine karşı glukoza bağlı kumarin türevlerinin in silico çalışması ve yapı-aktivite ilişkileri

, 2021
Bu çalışmada SARS-CoV-2 virüsüne karşı etkili olabilecek antiviral ilaç adaylarının tasarımları yapılmıştır. Moleküler yerleştirme, antiviral etkiye sahip kumarin ve türevlerinin, koronavirüsün temel proteinlerinden biri olan RNA polimeraz NSP12 ...
Bahattin Yalçın, Mücahit Özdemir, Esra Çelik, Baybars Köksoy   +3 more
core  

La mutation P323L de nsp12 de SARS-CoV-2est-elle un marqueur d’espèce hôte?

International audienceThe SARS-CoV-2 replication and transcription complex (RTC) provides RNA-dependent RNA polymerase (RdRp) activity. In its minimal composition, it consists of ‘non-structural proteins’, including nsp12 in complex with its protein ...
Falcou, Camille, Lo-Belo, Léa, Eydoux, Cécilia, Snijder, Eric, Canard, Bruno   +4 more
core   +1 more source

Is the P323L mutation in nsp12 of SARS-CoV-2 a host species marker?

The SARS-CoV-2 replication and transcription complex (RTC) provides RNA-dependent RNA polymerase (RdRp) activity. In its minimal composition, it consists of ‘non-structural proteins’, including nsp12 in complex with its protein cofactors: one copy of nsp7 and two of nsp8.
Falcou, Camille, Eydoux, Cécilia, Lo-Belo, Léa, Snijder, Eric, Canard, Bruno   +4 more
openaire   +1 more source

[In Press] A biochemical and biophysical analysis of the interaction of nsp9 with nsp12 from SARS-CoV-2 : implications for future drug discovery efforts

The ongoing global pandemic of the coronavirus 2019 (COVID-19) disease is caused by the virus SARS-CoV-2, with very few highly effective antiviral treatments currently available.
Cubeddu, Liza (R16726), Kwan, Ann, Artsimovitch, Irina, Gamsjaeger, Roland (R16936), Ataide, Sandro, El-Kamand, Serene (S33745), Baker, David L. (S37892), Wilkinson-White, Lorna, Wang, Bing, Allport, Thomas   +9 more
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Transient complexes of the Nsp7, Nsp8 and Nsp12 in SARS-CoV-2 replication transcription complex [PDF]

Acta Crystallographica Section A Foundations and Advances, 2021
openaire   +1 more source

Evolutionary inferences from the analysis of mutation dynamics in the SARS-CoV-2 replication-transcription complex. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Palyanov AY, Devyaterikov AP, Palyanova NV, Shestopalov AM.   +3 more
europepmc   +1 more source

Swine GBP1 restricts PDCoV replication via disrupting the replication and transcription complex formation. [PDF]

J Virol
Zhang K, Wang S, Kang X, Li F, Zhao Z, Nile W, Zhang C, Shen H, Du S, Kang H, Sun M, Liu Z, Zhang J.   +12 more
europepmc   +1 more source