Results 81 to 90 of about 40,674 (185)

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades [PDF]

, 2021
SARS-CoV-2 is currently causing major havoc worldwide with its efficient transmission and propagation. To track the emergence as well as the persistence of mutations during the early stage of the pandemic, a comparative analysis of SARS-CoV-2 whole ...
Uttamrao, Patil Pranita, Patro, L Ponoop Prasad, Sathyaseelan, Chakkarai, Rathinavelan, Thenmalarchelvi, Patil Pranita Uttamrao, Chakkarai Sathyaseelan, L Ponoop Prasad Patro, Thenmalarchelvi Rathinavelan   +7 more
core   +1 more source

In silico analysis of non-structural protein 12 sequences from SARS-COV-2 found in Manaus, Amazonas, Brazil, reveals mutations linked to higher transmissibility

Anais da Academia Brasileira de Ciências
The disease coronavirus COVID-19 has been the cause of millions of deaths worldwide. Among the proteins of SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part of the RNA-dependent RNA polymerase complex.
FERNANDO B. ZANCHI, GABRIEL EDUARDO M. FERREIRA, LUIS ANDRÉ M. MARIÚBA, JULIANE C. GLÓRIA, VALDINETE A. DO NASCIMENTO, VICTOR C. DE SOUZA, ANDRÉ DE LIMA G. CORADO, FERNANDA O. DO NASCIMENTO, ÁGATHA KÉLLY A. DA COSTA, DÉBORA CAMILA G. DUARTE, GEORGE ALLAN V. DA SILVA, MATILDE DEL CARMEN C. MEJÍA, KARINA P. PESSOA, LUCIANA MARA F. GONÇALVES, MARIA JÚLIA P. BRANDÃO, MICHELE S. DE JESUS, MARINEIDE S. DA SILVA, CRISTIANO F. DA COSTA, FELIPE G. NAVECA   +18 more
doaj   +1 more source

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

mLife, Volume 5, Issue 3, Page 339-354, June 2026.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang   +7 more
wiley   +1 more source

A genus-specific nsp12 region impacts polymerase assembly in Alpha- and Gammacoronaviruses

Abstract Coronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within the Coronavirinae subfamily and high infection frequency in ...
Peter J. Hoferle, Thomas K. Anderson, Robert N. Kirchdoerfer   +2 more
openaire   +2 more sources

NSP12 E802 mutation recapitulates change in RDV susceptibility.

, 2021
All viruses were derived by reverse genetics and have a SARS-CoV-2Wu1 backbone with specific point mutations as indicated. (A) Virus replication kinetics of rescued viruses with single mutation in either NSP12, NSP6 or both in Calu-3.
Andres Merits (191446), Gauthier Lieber (10196207), Meredith E. Stewart (11450472), Oscar A. MacLean (10297450), Alain Kohl (252931), Sam J. Wilson (9344990), Brian J. Willett (11450469), Rute Maria Pinto (10196222), Arthur Wickenhagen (9344984), Daniel Mair (5849150), Agnieszka M. Szemiel (10196243), Wilhelm Furnon (10196183), Nicolas M. Suarez (11450466), Matthew L. Turnbull (10196156), Massimo Palmarini (81656), Ana da Silva Filipe (5849153), Arvind H. Patel (10196255), Emma C. Thomson (10196249), Richard J. Orton (7832015), Sainan Wang (713604)   +19 more
core   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study

Indonesian Journal of Biotechnology
Human coronaviruses (HCoVs) are responsible for mild common cold to severe pneumonia‐like symptoms in infected individuals. The first HCoV was HCoV‐229E, discovered in 1962 in the US, which causes moderate symptoms.
Bhawna Sharma, Bennet Angel, Annette Angel, Vinod Joshi, Shareef Mohammed Buvvaji, Neha Singh, Khushbu Kumari, Aarya Chitransh, Poorna Khaneja, Devendra Kumar   +9 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

Antiviral Research, 2020
The rapid global emergence of SARS-CoV-2 has been the cause of significant health concern, highlighting the immediate need for antivirals. Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative treatment of several viral diseases, due to high ...
Shannon, Ashleigh, Le, Nhung Thi-Tuyet, Selisko, Barbara, Eydoux, Cecilia, Alvarez, Karine, Guillemot, Jean-Claude, Decroly, Etienne, Peersen, Olve, Ferron, Francois, Canard, Bruno   +9 more
openaire   +4 more sources

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source