Results 61 to 70 of about 40,674 (185)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Table_3_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.xlsx

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Host-dependent editing of SARS-CoV-2 in COVID-19 patients

Emerging Microbes and Infections, 2021
A common trait among RNA viruses is their high capability to acquire genetic variability due to viral and host mechanisms. Next-generation sequencing (NGS) analysis enables the deep study of the viral quasispecies in samples from infected individuals. In
Josep Gregori, Maria Francesca Cortese, Maria Piñana, Carolina Campos, Damir Garcia-Cehic, Cristina Andrés, Josep Francesc Abril, Maria Gema Codina, Ariadna Rando, Juliana Esperalba, Elena Sulleiro, Joan Joseph, Narcís Saubí, Sergi Colomer-Castell, Mari Carmen Martin, Carla Castillo, Juan Ignacio Esteban, Tomas Pumarola, Francisco Rodriguez-Frias, Andrés Antón, Josep Quer   +20 more
doaj   +1 more source

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

A genus-specific nsp12 region impacts polymerase assembly in Alphacoronavirus and Gammacoronavirus

Journal of Biological Chemistry
Coronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within the Coronavirinae subfamily and high infection frequency in animal species worldwide creates a looming threat that calls for research across all
Peter J. Hoferle, Thomas K. Anderson, Robert N. Kirchdoerfer   +2 more
openaire   +2 more sources

Table_2_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.xlsx

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

Image_1_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.tif

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP [PDF]

, 2021
Replication of the ∼30 kb-long coronavirus genome is mediated by a complex of non-structural proteins (NSP), in which NSP7 and NSP8 play a critical role in regulating the RNA-dependent RNA polymerase (RdRP) activity of NSP12.
Khudaverdyan, Nelli, Hai, Rong, Diggs, Stephen, Fang, Jian, Lu, Jiuwei, Biswal, Mahamaya, Song, Jikui, Xu, Duo, Blaha, Gregor, Stephen Diggs, Rong Hai, Jiuwei Lu, Jikui Song, Jian Fang, Duo Xu, Nelli Khudaverdyan, Gregor Blaha, Mahamaya Biswal   +17 more
core   +1 more source

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.

PLoS Pathogens, 2021
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports identifying SARS-CoV-2 RDV resistance in patients, animal models or in vitro ...
Agnieszka M Szemiel, Andres Merits, Richard J Orton, Oscar A MacLean, Rute Maria Pinto, Arthur Wickenhagen, Gauthier Lieber, Matthew L Turnbull, Sainan Wang, Wilhelm Furnon, Nicolas M Suarez, Daniel Mair, Ana da Silva Filipe, Brian J Willett, Sam J Wilson, Arvind H Patel, Emma C Thomson, Massimo Palmarini, Alain Kohl, Meredith E Stewart   +19 more
doaj   +1 more source