Results 41 to 50 of about 40,674 (185)
, 2022 Aim: COVID-19 is a global health threat. Therapeutics are urgently needed to cure patients severely infected with COVID-19. Objective: to investigate potential candidates of nsp12 inhibitors by searching for druggable cavity pockets within the viral ...
Mohsen Ebrahimi (9677858) +5 more
core +1 more source
Mechanism of nucleic acid unwinding by SARS-CoV helicase. [PDF]
PLoS ONE, 2012 The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5' → 3' polarity, using the energy of nucleotide hydrolysis.
Adeyemi O Adedeji +7 more
doaj +1 more source
Emerging Microbes and Infections, 2023 Zoonotic transmission of coronaviruses (CoVs) poses a serious public health threat. Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to ...
Yu-Lin Yao +16 more
doaj +1 more source
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Signal Transduction and Targeted Therapy, 2022 The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have ...
Saisai Guo +18 more
doaj +1 more source
Microorganisms, 2021 A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir ...
Alfredo Mari +24 more
doaj +1 more source
Arsenic trioxide could promote SARS-CoV-2 NSP12 protein degradation. [PDF]
J Gen VirolThe global dissemination and infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become a worldwide crisis with staggering confirmed cases and death tolls. Although prophylactic vaccines are widely applied to curb the spread of the virus, these protections are greatly weakened by the emergence of SARS-CoV-2 variants.
Yang T +4 more
europepmc +4 more sources
Molecular docking of cyanine and squarylium dyes with SARS‐CoV‐2 proteases NSP3, NSP5 and NSP12
Quantitative Biology, 2021 BackgroundThe outbreak and continued spread of coronavirus infection (COVID‐19) sets the goal of finding new tools and methods to develop analytical procedures and tests to detect, study infection and prevent morbidity.MethodsThe noncovalent binding of cyanine and squarylium dyes of different classes (60 compounds in total) with the proteases NSP3 ...
Pavel Pronkin, Alexander Tatikolov
openaire +1 more source
Pathogens, 2023 Heat shock protein 27 (HSP27) is a multifunctional protein and belongs to the small HSP family. It has been shown that HSP27 is involved in viral replication as a cellular chaperone, but the function of HSP27 during porcine reproductive and respiratory ...
Chunhui Song +4 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.A new exponential RCA (E‐RCA) system was developed and coupled to a toehold system for release of a bridging DNA, allowing for lateral flow detection. The E‐RCA method uses a secondary primer (P2) that binds RCA products (RCAP) to generate extended P2 products that can re‐prime a partially self‐complementary circular template, generating a complete ...
Amal Mathai +3 more
wiley +2 more sources
Microbiology Spectrum, 2022 Remdesivir (RDV) was the first antiviral drug approved by the FDA to treat severe coronavirus disease-2019 (COVID-19) patients. RDV inhibits SARS-CoV-2 replication by stalling the non structural protein 12 (nsp12) subunit of the RNA-dependent RNA ...
Marta Santos Bravo +24 more
doaj +1 more source