Results 41 to 50 of about 38,894 (153)

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

A genus-specific nsp12 region impacts polymerase assembly in Alphacoronavirus and Gammacoronavirus

Journal of Biological Chemistry
Coronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within the Coronavirinae subfamily and high infection frequency in animal species worldwide creates a looming threat that calls for research across all
Peter J. Hoferle, Thomas K. Anderson, Robert N. Kirchdoerfer   +2 more
openaire   +2 more sources

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Table_5_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.xlsx

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Tim Westphal, Marylyn Martina Addo (9161949), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Vanessa Ditt, Leon Cords (12446253), Julian Schulze zur Wiesch, Maria Mader (12629043), Alba Grifoni, Lennart Hermanussen (11096391), Alessandro Sette (19132), Leon Cords, Hendrik Karsten, Samuel Huber, Marc Lütgehetmann, Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), William W. Kwok (7380419), Alba Grifoni (3137199), Lennart Hermanussen, Marylyn Martina Addo, Alessandro Sette, Maria Mader, Sven Peine, Sophia Schulte (9302936), Sven Pischke, John Sidney, Maximilian Knapp, Maximilian Knapp (15414692), Vanessa Ditt (199087), William W. Kwok, Sven Pischke (511653), Sophia Schulte   +35 more
core   +1 more source

A Cross‐Sectional Study Shows Emergence of the Delta, 19B, 20A, 20B, 19A, and Omicron Variants of SARS‐CoV‐2 in Burkina Faso: A Conundrum Within a Conundrum

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Context and Objective SARS‐CoV‐2 is an RNA virus that emerged in Wuhan, China. Adaptive mutations in its genome can influence the virus's pathogenicity, enhance its ability to evade the host immune system, and complicate vaccine development. This study aimed to identify the circulating SARS‐CoV‐2 variants in Burkina Faso and trace their origin.
Tatiana Doriane Lallogo, Lassina Traore, Ezeckiel B. TIBIRI, P. Abel Sorgho, Prosper Bado, T. Edwige Yelemkoure, Pakyendou E. Name, Valérie J. T. E. Bazie, Fidèle Tiendrebeogo, H. Karim Sombie, Abdoul Karim Ouattara, Serge Théophile Soubeiga, Abdou Azaque Zoure, Albert Théophane Yonli, Brice Bicaba, Rakissida Alfred Ouedraogo, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Assita LAMIEN/SANOU, Olga M. Lompo, Jacques Simpore   +20 more
wiley   +1 more source

Image_3_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.tif

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba, Laura Hurtado‐Navarro, Diego Angosto‐Bazarra, Alberto Baroja‐Mazo, Pablo Pelegrin   +4 more
wiley   +1 more source

Table_3_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.xlsx

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source