Structural Homology-Based Drug Repurposing Approach for Targeting NSP12 SARS-CoV-2
Molecules, 2022 The severe acute respiratory syndrome coronavirus 2, also known as SARS-CoV-2, is the causative agent of the COVID-19 global pandemic. SARS-CoV-2 has a highly conserved non-structural protein 12 (NSP-12) involved in RNA-dependent RNA polymerase (RdRp ...
Abdulelah Aljuaid +10 more
doaj +3 more sources
Galectin 3-binding protein suppresses PRRSV replication via Cullin3-mediated ubiquitination degradation of non-structural protein 12 [PDF]
Journal of VirologyPorcine reproductive and respiratory syndrome virus (PRRSV) poses a major threat to the global swine industry, yet effective antiviral strategies remain limited.
Xinrong Wang +8 more
doaj +2 more sources
Antiviral Activity of Remdesivir and Obeldesivir Against SARS-CoV-2 Omicron Subvariants That Were Circulating from September 2023 Through June 2025 [PDF]
VirusesWith the ongoing emergence of SARS-CoV-2 variants, continued surveillance of antiviral susceptibility remains critical for detecting resistance that could compromise treatment efficacy.
Lauren Rodriguez +10 more
doaj +2 more sources
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex [PDF]
Virus ResearchCoronaviruses contain one of the largest genomes among the RNA viruses, coding for 14–16 non-structural proteins (nsp) that are involved in proteolytic processing, genome replication and transcription, and four structural proteins that build the core of ...
Maria Kuzikov +13 more
doaj +2 more sources
Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication [PDF]
Biophysical Journal, 2021 The replication transcription complex (RTC) from the virus SARS-CoV-2 is responsible for recognizing and processing RNA for two principal purposes. The RTC copies viral RNA for propagation into new virus and for ribosomal transcription of viral proteins.
Wilamowski, Mateusz +16 more
openaire +7 more sources
Fisetin as an Antiviral Agent Targeting the RNA-Dependent RNA Polymerase of SARS-CoV-2: Computational Prediction and In Vitro Experimental Validation [PDF]
MicroorganismsSARS-CoV-2 continues to evolve into immune-evasive variants, and although vaccination remains the cornerstone of prevention, the search for antiviral molecules targeting conserved viral enzymes remains essential.
Ximena Hernández-Rodríguez +15 more
doaj +2 more sources
Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins. [PDF]
ChemMedChemViral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
de la Cruz-Potenciano Á +3 more
europepmc +2 more sources
The worldwide search for the new mutations in the RNA-directed RNA Polymerase domain of SARS-CoV-2
Macedonian Veterinary Review, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an RNA virus, responsible for the current pandemic outbreak. In total, 200 genomes of the SARS‐CoV‐2 strains from four host organisms have been analyzed.
Siarhei A. Dabravolski +1 more
doaj +1 more source
Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: anin silicostructure-based approach [PDF]
, 2020 In this study, the Nsp12-Nsp8 complex of SARS-CoV-2 was targeted with structure-based and computer-aided drug design approach because of its vital role in viral replication.
Turgut-Balık, Dilek +10 more
core +3 more sources
NSP12-RNA binding structure and comparison of thermodynamic stability.
, 2023 (A) Overall view of NSP12 protein and location of the RDV. (B) RMSD comparison of RNA-binding proteins. (C) Comparison of the molecular vibrations of WT and each mutant.
Shiho Torii (12770667) +16 more
core +2 more sources