Results 31 to 40 of about 38,894 (153)
, 2022 Aim: COVID-19 is a global health threat. Therapeutics are urgently needed to cure patients severely infected with COVID-19. Objective: to investigate potential candidates of nsp12 inhibitors by searching for druggable cavity pockets within the viral ...
Mohsen Ebrahimi (9677858) +5 more
core +1 more source
Molecular docking of cyanine and squarylium dyes with SARS‐CoV‐2 proteases NSP3, NSP5 and NSP12
Quantitative Biology, 2021 BackgroundThe outbreak and continued spread of coronavirus infection (COVID‐19) sets the goal of finding new tools and methods to develop analytical procedures and tests to detect, study infection and prevent morbidity.MethodsThe noncovalent binding of cyanine and squarylium dyes of different classes (60 compounds in total) with the proteases NSP3 ...
Pavel Pronkin, Alexander Tatikolov
openaire +1 more source
Repurposed drug molecules targeting NSP12 protein of SARS-CoV-2: An in-silico study
AIMS Molecular Science, 2023 <abstract> <p>The emergence of SARS-CoV-2 created a havoc worldwide, causing high morbidity, serious complications and mortality. The ORF1ab of SARS-CoV-2 has 16 non-structural proteins which are required for genome replication and transcription. All of these are druggable targets, of which NSP12 (RNA-dependent RNA polymerase), was selected
Bhawna Sharma +14 more
openaire +2 more sources
Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 of the COVID-19 Virus
, 2020 COVID-19 is the causative agent for the ongoing pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive-sense single-stranded RNA genome.
deepak t nair, naveen narayanan
core +1 more source
Nsp7/Nsp8/Nsp12 competitively suppresses Nsp8 inhibitory function in antiviral responses.
, 2023 A-B. HEK293T cells harboring SARS-CoV-2 replicon were co-transfected with GFP-nsp8, GST-MDA5 or HA-TRIM4 plasmids in presence of Flag-nsp7/nsp12 overexpression (A), or GFP-nsp8 or Flag-nsp7/nsp12 plasmids in presence of GST-MDA5 and HA-TRIM4 ...
Qingyang Chen (17382920) +7 more
core +1 more source
Caspofungin and LTX-315 inhibit SARS-CoV-2 replication by targeting the nsp12 polymerase [PDF]
, 2020 Abstract The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously designated as 2019-nCoV) outbreak has caused global concern1. Currently, there are no clinically approved specific drugs or vaccines available for this virus.
Min Wang +17 more
openaire +1 more source
, 2023 IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949) +17 more
core +1 more source
Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2 [PDF]
Cell Reports, 2020 The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2). The viral polymerase is a promising antiviral target.
Peng, Qi +11 more
openaire +3 more sources
Nsp12 induces elevation of pSTAT1-S727 and expression of proinflammatory genes in HEK293 cells.
, 2013 A. Nsp12 induces elevation of pSTAT1-S727 in HEK293 cells. The cells were transfected with nsp12 or nps4 plasmids. The cells were harvested 48 h after transfection for Western blotting with antibodies against pSTAT1-S727, STAT1 and tubulin.
Yanjin Zhang (318768) +4 more
core +1 more source
NSP12 E802 mutation recapitulates change in RDV susceptibility.
, 2021 All viruses were derived by reverse genetics and have a SARS-CoV-2Wu1 backbone with specific point mutations as indicated. (A) Virus replication kinetics of rescued viruses with single mutation in either NSP12, NSP6 or both in Calu-3.
Andres Merits (191446) +19 more
core +1 more source