Results 51 to 60 of about 40,674 (185)
Repurposed drug molecules targeting NSP12 protein of SARS-CoV-2: An in-silico study
AIMS Molecular Science, 2023 <abstract> <p>The emergence of SARS-CoV-2 created a havoc worldwide, causing high morbidity, serious complications and mortality. The ORF1ab of SARS-CoV-2 has 16 non-structural proteins which are required for genome replication and transcription. All of these are druggable targets, of which NSP12 (RNA-dependent RNA polymerase), was selected
Bhawna Sharma +14 more
openaire +2 more sources
, 2023 IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949) +17 more
core +1 more source
Scientific Reports, 2021 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with fatal pulmonary fibrosis.
Seung Hyun Ahn +4 more
doaj +1 more source
Lycorine Derivative Inhibits SARS-CoV-2 Replication by Reducing -1 Programmed Ribosomal Frameshifting via Targeting ZAP. [PDF]
MedComm (2020)The present study evaluated the antiviral potential of various lycorine derivatives and identified compound 7 as a promising candidate. Compound 7 demonstrated strong antiviral efficacy against both the original SARS‐CoV‐2 and its variants in vitro and in vivo.
Du T +11 more
europepmc +2 more sources
PLoS ONE, 2021 The 2019 emergence of, SARS-CoV-2 has tragically taken an immense toll on human life and far reaching impacts on society. There is a need to identify effective antivirals with diverse mechanisms of action in order to accelerate preclinical development ...
Matthew R Freidel, Roger S Armen
doaj +1 more source
Nsp7/Nsp8/Nsp12 competitively suppresses Nsp8 inhibitory function in antiviral responses.
, 2023 A-B. HEK293T cells harboring SARS-CoV-2 replicon were co-transfected with GFP-nsp8, GST-MDA5 or HA-TRIM4 plasmids in presence of Flag-nsp7/nsp12 overexpression (A), or GFP-nsp8 or Flag-nsp7/nsp12 plasmids in presence of GST-MDA5 and HA-TRIM4 ...
Qingyang Chen (17382920) +7 more
core +1 more source
PLoS ONE, 2021 To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed.
Clément Madru +6 more
doaj +1 more source
Nsp12 induces elevation of pSTAT1-S727 and expression of proinflammatory genes in HEK293 cells.
, 2013 A. Nsp12 induces elevation of pSTAT1-S727 in HEK293 cells. The cells were transfected with nsp12 or nps4 plasmids. The cells were harvested 48 h after transfection for Western blotting with antibodies against pSTAT1-S727, STAT1 and tubulin.
Yanjin Zhang (318768) +4 more
core +1 more source
Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 of the COVID-19 Virus
, 2020 COVID-19 is the causative agent for the ongoing pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive-sense single-stranded RNA genome.
deepak t nair, naveen narayanan
core +1 more source
, 2023 IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949) +17 more
core +1 more source