Results 71 to 80 of about 40,674 (185)

Caspofungin and LTX-315 inhibit SARS-CoV-2 replication by targeting the nsp12 polymerase [PDF]

, 2020
Abstract The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously designated as 2019-nCoV) outbreak has caused global concern1. Currently, there are no clinically approved specific drugs or vaccines available for this virus.
Min Wang, Fei Ye, Jiaqi Su, Jingru Zhao, Bin Yuan, Baoying Huang, Qi Peng, Ruchao Peng, Yan Sun, Suran Bai, Xixi Wang, Wei Yang, Zheng Fan, Wenling Wang, Guizhen Wu, George F Gao, Wenjie Tan, Yi Shi   +17 more
openaire   +1 more source

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2 [PDF]

Cell Reports, 2020
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2). The viral polymerase is a promising antiviral target.
Peng, Qi, Peng, Ruchao, Yuan, Bin, Zhao, Jingru, Wang, Min, Wang, Xixi, Wang, Qian, Sun, Yan, Fan, Zheng, Qi, Jianxun, Gao, George F., Shi, Yi   +11 more
openaire   +3 more sources

Table_4_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.xlsx

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

Table_5_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.xlsx

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Tim Westphal, Marylyn Martina Addo (9161949), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Vanessa Ditt, Leon Cords (12446253), Julian Schulze zur Wiesch, Maria Mader (12629043), Alba Grifoni, Lennart Hermanussen (11096391), Alessandro Sette (19132), Leon Cords, Hendrik Karsten, Samuel Huber, Marc Lütgehetmann, Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), William W. Kwok (7380419), Alba Grifoni (3137199), Lennart Hermanussen, Marylyn Martina Addo, Alessandro Sette, Maria Mader, Sven Peine, Sophia Schulte (9302936), Sven Pischke, John Sidney, Maximilian Knapp, Maximilian Knapp (15414692), Vanessa Ditt (199087), William W. Kwok, Sven Pischke (511653), Sophia Schulte   +35 more
core   +1 more source

Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes

Viruses, 2015
Human coronavirus OC43 (HCoV-OC43) is one of five currently circulating human coronaviruses responsible for respiratory infections. Like all coronaviruses, it is characterized by its genome’s high plasticity.
Nathalie Kin, Fabien Miszczak, Wei Lin, Meriadeg Ar Gouilh, Astrid Vabret, Epicorem Consortium   +5 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, Volume 13, Issue 59, 23 October 2026.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Image_3_Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses.tif

, 2023
IntroductionThe nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC).MethodsHere, we comprehensively assessed the breadth and ...
Marylyn Martina Addo (9161949), Alba Grifoni (3137199), Tim Westphal (15414689), Marc Lütgehetmann (6807842), Sophia Schulte (9302936), Leon Cords (12446253), Maria Mader (12629043), Lennart Hermanussen (11096391), Alessandro Sette (19132), Maximilian Knapp (15414692), Vanessa Ditt (199087), Samuel Huber (56057), Hendrik Karsten (11441924), John Sidney (19127), Julian Schulze zur Wiesch (8343450), Sven Peine (3545648), Sven Pischke (511653), William W. Kwok (7380419)   +17 more
core   +1 more source

BST2 negatively regulates porcine reproductive and respiratory syndrome virus replication by restricting the expression of viral proteins

Virus Research, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV) has seriously affected the viability of swine industries worldwide, and effective measures to control PRRSV are urgently required. Understanding the mechanisms of action of antiviral proteins is
Yujiao Zhang, Ning Kong, Jinfeng Ti, Dongshen Cao, Zhaofeng Sui, Aimin Ge, Liuting Pan, Kuan Zhao, Yanjun Zhou, Guangzhi Tong, Liwei Li, Fei Gao   +11 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source