Results 71 to 80 of about 38,894 (153)

Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound naringenin as a promising drug candidate against COVID-19

, 2023
The prevalence of SARS-CoV-2-induced respiratory infections is now a major challenge worldwide. There is currently no specific antiviral drug to prevent or treat this disease.
Hamed Ghoshouni, Sara Hanaei, Elham Aleebrahim, Ghoshouni, Hamed, Elahe Aleebrahim-Dehkordi, Chichagi, Fatemeh, Nima Rezaei, Aleebrahim, Elham, Rezaei, Nima, Mohsen Esmaili-Dehkordi, Ehsan Heidari-Soureshjani, Jafari, Ali, Pooneh Koochaki, Fatemeh Chichagi, Aleebrahim-Dehkordi, Elahe, Esmaili-Dehkordi, Mohsen, Koochaki, Pooneh, Hanaei, Sara, Ali Jafari, Heidari-Soureshjani, Ehsan   +19 more
core   +1 more source

Implementation of a Multiplex PCR Amplification System Combined With Next‐Generation Genome Sequencing to Decipher the Circulation of Human Coronavirus 229E Lineages in Southern France

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Coronaviruses rapidly evolve and are prone to new virus emergence. Human coronavirus (HCoV)−229E is one of the seven coronaviruses (aside HCoV‐OC43, HCoV‐HKU1, HCoV‐NL63, SARS‐CoV, MERS‐CoV, SARS‐CoV‐2) causing respiratory infections in humans. Genomic data are very scarce for this virus.
Houmadi Hikmat, Justine Py, Céline Boschi, Emilie Burel, Lorlane Le Targa, Matthieu Million, Lucile Lesage, Aurélie Morand, Bernard La Scola, Philippe Colson   +9 more
wiley   +1 more source

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

Acta Crystallographica Section D, Volume 81, Issue 11, Page 630-645, November 2025.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz, Jan Wollenhaupt, Melanie Oelker, Paula Fröling, Uwe Mueller, Anke Deckers, Christoph Grathwol, Stefan Bräse, Nicole Jung, Manfred S. Weiss   +9 more
wiley   +1 more source

Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

, 2021
The mutational landscape of SARS-CoV-2 varies at both the dominant viral genome sequence and minor genomic variant population. An early change associated with transmissibility was the D614G substitution in the spike protein.
Salguero, Francisco, Jones, Benjamin, Erdmann, Maximilian, Goldswain, Hannah, Turtle, Lance, Hall, Yper, Semple, Malcolm, Tree, Julia, Hiscox, Julian, Shawli, Ghada, Openshaw, Peter, Emmett, Stevan, Prince, Tessa, Davidson, Andrew, Penrice-Randal, Rebekah, Baille, Kenneth, Digard, Paul, Dong, Xiaofeng, Williamson, Maia Kavanagh, Matthews, David, Carroll, Miles, Hartley, Catherine, Randle, Nadine, Jearanaiwitayakul, Tuksin, ISARIC4C investigators, Darby, Alistair, Bazire, James   +26 more
core   +1 more source

SARS-CoV-2 NSP12 utilizes various host splicing factors for replication and splicing regulation

, 2023
Abstract Background The RNA-dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of RNA viruses. Although the RdRps of lethal human coronaviruses SARS-CoV-2, SARS-CoV, and MARS-CoV have been extensively studied, the molecular mechanism of the catalytic subunit NSP12, which is involved in pathogenesis ...
Li Yang, Xiao-Tao Zeng, Si-Xue Ren, Lin-Lin Liang, Qiu-Xia Huang, Hong Fan, Hai-Yan Ren, Wei Cheng   +7 more
openaire   +1 more source

Arterivirus NSP12 versus the coronavirus NSP16 29-O-methyltransferase: Comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins

, 2021
The 39-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a (putative) 29-O-methyltransferase (29-O-MTase), known as non structural protein (nsp) 16 in the ...
Lehmann K.C.
core  

Molecular modelling and structure-activity relationship of a natural derivative of o-hydroxybenzoate as a potent inhibitor of dual NSP3 and NSP12 of SARS-CoV-2: in silico study

, 2022
The nsp3 macrodomain and nsp12 (RdRp) enzymes are strongly implicated in the virulent regulation of the host immune response and viral replication of SARS-CoV-2, making them plausible therapeutic targets for mitigating infectivity. Remdesivir remains the
Mohd Nizam Mordi (8071904), Yahaya Sani Najib (11955670), Yusuf Oloruntoyin Ayipo (11955667), Iqrar Ahmad (8499111), Sikirat Kehinde Sheu (11955673), Harun Patel (6649328)   +5 more
core   +1 more source

Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2

, 2020
A novel coronavirus (SARS-CoV-2) that is initially found to trigger human severe respiratory illness in Wuhan City of China in 2019, has killed 2,718 people in China by February 26, 2020, and which has been recognized as a public health emergency of international concern as well.
Zijing Ruan, Chao Liu, Yuting Guo, Zhenqing He, Xinhe Huang, Xu Jia, Tai Yang   +6 more
openaire   +2 more sources

Genomic characterization of SARS‐CoV‐2 isolates from patients in Turkey reveals the presence of novel mutations in spike and nsp12 proteins

, 2021
Novel mutations have been emerging in the genome of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2); consequently, the evolving of more virulent and treatment resistance strains have the potential to increase transmissibility and mortality ...
Tunccan, ÖZLEM, Isil Fidan, Yigit, Selin, Kayhan Caglar, Erdem Sahin, Gulendam Bozdayi, Muftah, Hager, Sahin, Erdem, Ozlem G. Tunccan, Dizbay, MURAT, Selin Yigit, Murat Dizbay, Bozdayi, GÜLENDAM, Fidan, IŞIL, Caglar, KAYHAN, Hager Muftah   +15 more
core   +1 more source

Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins

, 2023
The COVID-19 pandemic caused by SARS-CoV-2 virus has created a global damage and has exposed the vulnerable side of scientific research towards novel diseases.
Isaac, Samuel Paul, Zeeshan Ali (5950430), Samuel Paul Isaac (14571083), Tanos C. C. França (9286671), Vijay Pratap Singh (11326669), Singh, Vijay P., Jyothsna Volisha Cardoza (14571080), Basak, Srijita, George, Sudhan S., Utkarsh Narsaria (11300252), Franca, Tanos Celmar Costa, AliYas, Zeinaib, Cardoza, Jyothsna Volisha, Laplante, Steven, Sudhan S. George (14571086), Steven R. LaPlante (1833688), Srijita Basak (9350927), Narsaria, Utkarsh   +17 more
core   +1 more source