Results 131 to 140 of about 3,842 (144)

Novel nsp13 inhibitors capable of blocking viral replication of SARS-CoV-2.

2023
For RNA viruses, RNA helicases have long been recognized to play critical roles during virus replication cycles, facilitating proper folding and replication of viral RNAs, therefore representing an ideal target for drug discovery. SARS-CoV-2 helicase, the non-structural protein 13 (nsp13) is a highly conserved protein among all known coronaviruses, and,
Arpacioglu, M., Madia, V. N., Messore, A., Patacchini, E., Ialongo, D., Tudino, V., Scipione, L., Corona, A., Esposito, F., Artico, M., Amatore, D., Faggioni, G., De Santis, R., Lista, F., Tramontano, E., Costi, R., Di Santo, R.   +16 more
openaire   +1 more source

Potential phytochemical inhibitors of SARS-CoV-2 helicase Nsp13: a molecular docking and dynamic simulation study

Molecular Diversity, 2021
R P Vivek-Ananth, Sankaran Krishnaswamy, Areejit Samal   +2 more
exaly  

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

Journal of Virology, 2023
Kaitao Zhao, Zhinang Yin, Zaichao Xu
exaly  

What a twist: structural biology of the SARS-CoV-2 helicase nsp13

Crystallography Reviews, 2023
Sam Horrell, Sam Martino, Ferdinand Kirsten, Dénes Berta, Gianluca Santoni, Andrea Thorn   +5 more
openaire   +1 more source

New quinolinonyl derivatives as SARS-CoV-2 nsp13 inhibitors

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent behind the 2019 global coronavirus pandemic (COVID-19). Even though successful vaccination programs to counteract COVID-19 are available worldwide, little has been accomplished in the development of antivirals to treat the disease.
Albano, A., Madia, V. N., Ruggieri, G., Ialongo, D., Patacchini, E., Arpacioglu, M., Messore, A., Scipione, L., Corona, A., Esposito, F., Amatore, D., Faggioni, G., De Santis, R., Lista, F., Tramontano, E., Di Santo, R., Costi, R.   +16 more
openaire   +1 more source

Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase

Journal of Biomolecular Structure and Dynamics, 2022
Rajat Nandi, Rakesh Srivastava, Amresh Prakash   +2 more
exaly  

New nitrogen based derivatives as SARS-CoV-2 nsp13 inhibitors

The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which spread around the world and caused the 2019–2020 pandemic. Even though successful vaccination programs to combat COVID-19 are available worldwide, little has been accomplished in ...
Albano, A., Madia, V. N., Ruggieri, G., Ialongo, D., Patacchini, E., Arpacioglu, M., Messore, A., Scipione, L., Corona, A., Esposito, F., Amatore, D., Faggioni, G., De Santis, R., Lista, F., Tramontano, E., Di Santo, R., Costi, R.   +16 more
openaire   +1 more source

SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts

Virologica Sinica, 2020
Muhan Huang, Yujie Ren, Jingfang Mu
exaly  

Structure-activity relationships of indolyl derivatives as SARS-CoV-2 nsp13 inhibitors

The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic strategies that target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). So far, these efforts have led to multiple successful vaccines in an exceptionally rapid time frame, as well as the evaluation of a wide range of potential ...
Madia, V. N., Albano, A., Ruggieri, G., Ialongo, D., Patacchini, E., Arpacioglu, M., Messore, A., Scipione, L., Corona, A., Esposito, F., Amatore, D., Faggioni, G., De Santis, R., Lista, F., Tramontano, E., Di Santo, R., Costi, R.   +16 more
openaire   +1 more source

Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase

Journal of Pharmaceutical Analysis, 2020
Muhammad Usman Mírzá, Matheus Froeyen
exaly