Results 61 to 70 of about 7,712 (169)

SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB

Viruses, 2023
COVID-19 is associated with robust inflammation and partially impaired antiviral responses. The modulation of inflammatory gene expression by SARS-CoV-2 is not completely understood. In this study, we characterized the inflammatory and antiviral responses mounted during SARS-CoV-2 infection. K18-hACE2 mice were infected with a Wuhan-like strain of SARS-
Émile Lacasse, Leslie Gudimard, Isabelle Dubuc, Annie Gravel, Isabelle Allaeys, Éric Boilard, Louis Flamand   +6 more
openaire   +3 more sources

Viroplasms: Assembly and Functions of Rotavirus Replication Factories

Viruses, 2021
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formation ...
Guido Papa, Alexander Borodavka, Ulrich Desselberger   +2 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Enhanced Nitrogen Uptake and Early Flowering Mitigate Fitness Costs Associated With Glufosinate Resistance in Goosegrass (Eleusine indica)

Food and Energy Security, Volume 15, Issue 4, July/August 2026.
Schematic representation of fitness trade‐offs driven by the GS1‐1Ser59Gly mutation in glufosinate‐resistant Eleusine indica. ABSTRACT Herbicide resistance in weeds is frequently accompanied by fitness trade‐offs that compromise survival and reproductive success.
Xinyu Cui, Hanxia Yu, Junjie You, Yinzhi Lv, Xingshan Tian, Chun Zhang   +5 more
wiley   +1 more source

The Junction Between nsp1β and nsp2 in the Porcine Reproductive and Respiratory Syndrome Virus Genome Is a New Site for the Insertion and Expression of Foreign Genes

Viruses
Porcine reproductive and respiratory syndrome virus (PRRSV) is considered a promising viral vector for the expression and delivery of foreign genes for the development of a new generation of multi-valent vaccines against PRRSV and other porcine viruses ...
Changguang Xiao, Yafang Lin, Hailong Zhang, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Zhiyong Ma, Jianchao Wei   +9 more
doaj   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5

MedComm, Volume 7, Issue 6, June 2026.
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie, Sabrina Noettger, Jan Lawrenz, Sophie Stopper, Susanne Klute, Jan Münch, Dorota Kmiec, Qingxing Wang, Konstantin M. J. Sparrer, Frank Kirchhoff   +9 more
wiley   +1 more source

Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus

Virus Research, 2008
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes epidemic fever, rash and polyarthralgia in Africa and Asia. Although it is known since the 1950s, new epidemiological and clinical features reported during the recent outbreak in the Indian Ocean can be regarded as the emergence of a new disease. Numerous severe forms of the infection
Pastorino, Boris A.M., Peyrefitte, Christophe N., Almeras, Lionel, Grandadam, Marc, Rolland, Dominique, Tolou, Hugues J., Bessaud, Maël   +6 more
openaire   +2 more sources

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

mLife, Volume 5, Issue 3, Page 339-354, June 2026.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang   +7 more
wiley   +1 more source

Viral Mechanisms and Drug Influences on Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Pathway in Human Coronaviruses Infection: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Caleb Koranteng Kwayisi‐Darkwah, Gabriel Atampugbire, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +7 more
wiley   +1 more source