Results 81 to 90 of about 7,712 (169)

An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

ACS Infectious Diseases
Abstract Chikungunya virus (CHIKV) replication relies on the multifunctional nsP2 protein, making it an attractive target for antiviral drug discovery. Here, we report the resolution of oxaspiropiperidine 1 , a first-in-class inhibitor of the CHIKV nsP2 RNA helicase (nsP2hel), into ...
Bose Muthu Ramalingam, Hans J. Oh, John D. Sears, Chun-Hsing Chen, Anand Vala, Shubin Liu, Kacey M. Talbot, Mohammed Anwar Hossain, Peter J. Brown, Scott Houliston, Julia Garcia Perez, Fengling Li, Meareg G. Amare, Peter Halfmann, Jessica L. Smith, Alec J. Hirsch, Cheryl H. Arrowsmith, Levon Halabelian, Ava Vargason, Rafael M. Couñago, Jamie J. Arnold, Craig E. Cameron, Nathaniel J. Moorman, Mark T. Heise, Timothy M. Willson   +24 more
openaire   +3 more sources

Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation

Veterinary Research
Getah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health.
Hua Liu, Zhao Qi, Lan Tian, Zhe Chen, Haonan Li, Le Liu, Sicong Liu, Shuai Li, Jiumeng Sun, Ying Shao, Xiangjun Song, Jian Tu, Liangqiang Zhu, Kezong Qi, Zhenyu Wang   +14 more
doaj   +1 more source

ATP synthase subunit ATP5B interacts with TGEV Nsp2 and acts as a negative regulator of TGEV replication

Virulence
Coronavirus nonstructural protein 2 (Nsp2) is regarded as a virulence determinant and plays a critical role in virus replication, and innate immunity. Screening and identifying host cell proteins that interact with viral proteins is an effective way to ...
Yanan Wang, Aoying Sun, Yaru Guo, Lingxiang Xin, Yanping Jiang, Wen Cui, Jiaxuan Li, Yijing Li, Li Wang   +8 more
doaj   +1 more source

The Arterivirus Nsp2 Protease. [PDF]

Journal of Biological Chemistry, 1995
Eric J. Snijder, Alfred L.M. Wassenaar, Willy J.M. Spaan, Alexander E. Gorbalenya   +3 more
openaire   +1 more source

A Robust Fluorogenic Substrate for Chikungunya Virus Protease (nsP2) Activity

Protein Science
ABSTRACT Chikungunya virus (CHIKV) is an emerging pathogen with pandemic potential. CHIKV infection in humans is transmitted by mosquitoes and induces common symptoms of high fever, arthralgia and myalgia. Because no specific antiviral drugs for treatment of CHIKV infection are available, drug development remains a ...
Sparsh Makhaik, Wioletta Rut, Shruti Choudhary, Tulsi Upadhyay, Chenzhou Hao, Michael Westberg, Cedric Bobst, Euna Yoo, Jasna Fejzo, Michael Z. Lin, Matthew Bogyo, Paul Thompson, Marcin Drag, Jeanne A. Hardy   +13 more
openaire   +4 more sources

Molecular Characterization of the Porcine Group A Rotavirus NSP2 and NSP5/6 Genes from São Paulo State, Brazil, in 2011/12

The Scientific World Journal, 2013
Rotaviruses are responsible for the acute diarrhea in various mammalian and avian species. The nonstructural proteins NSP2 and NSP5 are involved in the rotavirus replication and the formation of viroplasm, cytoplasmic inclusion bodies within which new ...
Bruna Rocha Passos Barbosa, Nara Thiers Cacciatori Galleti Bernardes, Laila Andreia Rodrigues Beserra, Fábio Gregori   +3 more
doaj   +1 more source

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I.

PLoS Pathogens
Non-structural protein 2 (NSP2) of PRRSV is highly variable and plays crucial roles in the virus's life cycle. To elucidate the function of NSP2 during PRRSV infection, we identified SH3KBP1 as an NSP2-interacting host protein using mass spectrometry ...
Jiaoyang Li, Jing Zhang, Pu Sun, Jian Wang, Guoxiu Li, Zhanding Cui, Dong Li, Hong Yuan, Tao Wang, Kun Li, Xingwen Bai, Zhixun Zhao, Yimei Cao, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Zaixin Liu, Shuqi Xiao, Xinglong Wang, Zengjun Lu   +20 more
doaj   +1 more source

Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus

Viruses, 2015
Porcine reproductive and respiratory syndrome virus (PRRSV) is currently one of the most important viruses affecting the swine industry worldwide. Despite the large number of papers published each year, the participation of non-structural proteins (nsps)
Edgar Rascón-Castelo, Alexel Burgara-Estrella, Enric Mateu, Jesús Hernández   +3 more
doaj   +1 more source

New insights into alphaviral nsP2 functions

, 2023
Over the last decades, the intensive studies of factors/activities responsible for multiple aspects of alphavirus infection have been performed. In particular, our understanding about structures and functions of viral RNA replicase and its components has significantly increased. Novel findings emphasize that one of the first and most essential event in
openaire   +1 more source

Unlocking the role of NSP1 and NSP2: nutrient-responsive regulators in nodulation

Trends in Plant Science
Symbiotic nitrogen fixation represents a crucial yet energy-demanding strategy for legumes to survive in nutrient-poor soils. We highlight the multifaceted roles of NSP1 and NSP2 in this symbiosis and propose their function as 'nutrient-responsive regulators', integrating environmental signals, physiological status, and nutrient availability, to ensure
Jin-Peng Gao, Chai Hao Chiu, Giles E.D. Oldroyd   +2 more
openaire   +3 more sources