Results 131 to 140 of about 5,845 (181)

Design and selection of an intrabody library produced de-novo for the non-structural protein NSP5 of rotavirus.

, 2005
Intracellular antibodies or intrabodies have great potential in protein knockout strategies for intracellular antigens. We applied the Intracellular Antibody Capture Technology for the direct selection in yeast of a mouse scFv library (V(L)-V(H) format ...
BURRONE OR, VASCOTTO F, VISINTIN M, CATTANEO, ANTONINO   +3 more
core  

Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections

Nature Communications
We investigated the impact of antiviral treatment on the emergence of SARS-CoV-2 resistance during persistent infections in immunocompromised patients (n = 15).
Mohammed Nooruzzaman, Katherine E. E. Johnson, Ruchi Rani, Eli J. Finkelsztein, Leonardo C. Caserta, Rosy P. Kodiyanplakkal, Wei Wang, Jingmei Hsu, Maria T. Salpietro, Stephanie Banakis, Joshua Albert, Lars F. Westblade, Claudio Zanettini, Luigi Marchionni, Rosemary Soave, Elodie Ghedin, Diego G. Diel, Mirella Salvatore   +17 more
doaj   +1 more source

Uncoupling substrate and activation functions of rotavirus NSP5: Phosphorylation of Ser-67 by casein kinase 1 is essential for hyperphosphorylation [PDF]

, 2004
Rotavirus NSP5 is a nonstructural protein that localizes in viro-plasms of virus-infected cells. NSP5 interacts with NSP2 and undergoes a complex post-translational hyperphosphorylation, generating species with reduced PAGE mobility.
Muszynski, Bartosz, Jacob Ahumada, Germaine, Burrone, Oscar R., Eichwald, Catherine, Allende, Jorge E.   +4 more
core  

Cellular sensor DAP5 decodes <i>Betacoronaviral</i> NSP5 to drive virus-induced senescence. [PDF]

Front Immunol
Lu Y, Xiao J, Wang J, Meng Z, Fan G, Zheng J, Yu M, Wang X, Li L.   +8 more
europepmc   +1 more source

PRRSV-2 impedes lysosomes from eliminating secondary infected bacteria. [PDF]

PLoS Pathog
Zheng Z, Ling X, Qiao S, Wu J, Zhang S, Liu X, Li Y, Xie C, Ma Z, Guo X, Li Z, Feng Y, Xu L, Zhang J, Zheng H, Xiao S.   +15 more
europepmc   +1 more source

Cleavage at the nsp5-nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form. [PDF]

J Biol Chem
Aniana A, Nashed NT, Ghirlando R, Bhandari D, Kovalevsky A, Louis JM.   +5 more
europepmc   +1 more source

Generation of G9 genotype porcine rotavirus using reverse genetics system and its application for antiviral screen and vaccine development. [PDF]

Virol Sin
Han N, Tao R, Cheng X, Deng H, Wang J, Bian X, Zhou J, Zhu X, Sun M, Zhang X, Hu M, Guo R, Wang W, Ding S, Li B.   +14 more
europepmc   +1 more source

Porcine reproductive and respiratory syndrome virus exploits ESCRT-II subunit EAP20 for entry and replication. [PDF]

J Virol
Zhang L, Jiang Y, Li R, Wang M, Wang X, Zhu J, Yan N, Qiao S, Li R, Wang Y.   +9 more
europepmc   +1 more source

Modulation of Host Innate Immune Response by Highly Pathogenic Human Coronaviruses during Viral Infection. [PDF]

J Microbiol Biotechnol
Kim YJ, Lee SJ, Lee W, Kim SJ, Ahn DG.
europepmc   +1 more source

MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18. [PDF]

Front Immunol
Zhang Y, Stevenson NJ.
europepmc   +1 more source