Results 151 to 160 of about 9,177 (185)

Concept of Viral Inhibitors via NTCP

Seminars in Liver Disease, 2019
AbstractIdentification of sodium taurocholate cotransporting polypeptide (NTCP) as an entry receptor for hepatitis B and D viruses (HBV and HDV) has not only promoted our understanding of the mechanism underlying the viral entry process, but also provided cell culture models supporting viral infection.
Kento, Fukano, Senko, Tsukuda, Koichi, Watashi, Takaji, Wakita   +3 more
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A representation of an NTCP function for local complication mechanisms

Physics in Medicine and Biology, 2001
A mathematical formalism was tailored for the description of mechanisms complicating radiation therapy with a predominantly local component. The functional representation of an NTCP function was developed based on the notion that it has to be robust against population averages in order to be applicable to experimental data. The model was required to be
M, Alber, F, Nüsslin
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HBV: Stowaway of NTCP

Clinics and Research in Hepatology and Gastroenterology, 2014
Several recent papers support the view that Na-taurocholate cotransporting polypeptide (NTCP), the sinusoidal bile acid transporter of hepatocytes, is a cell surface receptor enabling entry into these cells of the hepatitis B virus (HBV). This major advance in the understanding of the HBV life cycle paves the way to new therapeutic strategies aimed at ...
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Validation of automatic segmentation of ribs for NTCP modeling

Radiotherapy and Oncology, 2016
Determination of a dose-effect relation for rib fractures in a large patient group has been limited by the time consuming manual delineation of ribs. Automatic segmentation could facilitate such an analysis. We determine the accuracy of automatic rib segmentation in the context of normal tissue complication probability modeling (NTCP).Forty-one ...
Barbara Stam, Heike Peulen, Maddalena M.G. Rossi, José S.A. Belderbos, Jan-Jakob Sonke   +4 more
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Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes

Journal of Pharmaceutical Sciences, 2013
Species differences among membrane transporters can be remarkable and difficult to properly assess by conventional methods. Herein, we employed the first use of stable isotope labeling in mammals or stable isotope-labeled peptides combined with mass spectrometry to identify species differences in sodium taurocholate cotransporting polypeptide (NTCP ...
Xi, Qiu, Yi-An, Bi, Larissa M, Balogh, Yurong, Lai   +3 more
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Structure of the bile acid transporter and HBV receptor NTCP

Nature, 2022
Chronic infection with hepatitis B virus (HBV) affects more than 290 million people worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an estimated 820,000 deaths annually1,2. For HBV infection to be established, a molecular interaction is required between the large glycoproteins of the virus envelope (known as LHBs ...
Jinta Asami, Kanako Terakado Kimura, Yoko Fujita-Fujiharu, Hanako Ishida, Zhikuan Zhang, Yayoi Nomura, Kehong Liu, Tomoko Uemura, Yumi Sato, Masatsugu Ono, Masaki Yamamoto, Takeshi Noda, Hideki Shigematsu, David Drew, So Iwata, Toshiyuki Shimizu, Norimichi Nomura, Umeharu Ohto   +17 more
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NTCP-Reconstituted In Vitro HBV Infection System

2016
Sodium taurocholate cotransporting polypeptide (NTCP) has been identified as a functional receptor for hepatitis B virus (HBV). Expressing human NTCP in human hepatoma HepG2 cells (HepG2-NTCP) renders these cells susceptible for HBV infection. The HepG2-NTCP stably transfected cell line provides a much-needed and easily accessible platform for studying
Yinyan, Sun, Yonghe, Qi, Bo, Peng, Wenhui, Li   +3 more
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On the limitations of the area under the ROC curve for NTCP modelling

Radiotherapy and Oncology, 2020
The area under the ROC curve (AUC) is commonly used as a measure for the discriminative performance of NTCP models. Here, we demonstrate that for typical patient cohorts, the AUC is an unsuitable measure for that purpose since it is typically limited to values below 0.8 and it exhibits large statistical variation.
Emanuel Bahn, Markus Alber
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TCP and NTCP: a basic introduction.

Rays, 2006
Radiotherapy is one of the most effective treatments for cancer. The aim of radiotherapy is to achieve a high probability of local tumor control (tumor control probability, TCP) at a low risk of normal tissue complications (normal tissue complication probability, NTCP).
Michael, Baumann, Cordula, Petersen
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A NTCP approach for estimating the outcome in radioiodine treatment of hyperthyroidism

Medical Physics, 2008
Radioiodine has been in use for over as a treatment for hyperthyroidism. Major changes in clinical practice have led to accurate dosimetry capable of avoiding the risks of adverse effects and the optimization of the treatment. The aim of this study was to test the capability of a radiobiological model, based on normal tissue complication probability ...
L, Strigari, R, Sciuto, M, Benassi, S, Bergomi, S, Nocentini, C L, Maini   +5 more
openaire   +2 more sources