Results 171 to 180 of about 4,073 (199)

Nontypeable Haemophilus influenzae (NTHi)

Trends in Microbiology, 2018
In this infographic the diseases caused by nontypeable Haemophilus influenzae (NTHi), including otitis media, are discussed. Encapsulated type b Haemophilus influenzae (Hib) was responsible for most of the invasive disease (meningitis) prior to the use of Hib vaccines. As Hib vaccines have no effect on infections due to nontypeable H. influenzae (NTHi),
Lauren Bakaletz, Laura Novotny
exaly   +3 more sources

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF [PDF]

Biochemical and Biophysical Research Communications, 2007
Mucin, a major component of mucus, plays a critical role in host mucosal defense response by participating in mucociliary clearance. However, if overproduced, overproduced mucus leads to airway mucus obstruction and conductive hearing loss. Despite extensive studies that focus on investigating how MUC5AC mucin is regulated by one inducer at a time, how
Hirofumi Kai, Huang Yuxian, Chen Yan
exaly   +3 more sources

In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of Haemophilus haemolyticus [PDF]

Pathogens, 2020
Nontypeable Haemophilus influenzae (NTHi) is a leading causative organism of opportunistic respiratory tract infections. However, there are currently no effective vaccination strategies, and existing treatments are compromised by antibiotic resistance ...
Brianna Atto, Dale Kunde, Roger Latham   +2 more
exaly   +1 more source

[Study on the anti-NTHi infection of Hap recombinant protein in vivo].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2010
To observe the immune effect of Hap recombinant protein on murine model of bronchopneumonia infected with NTHi, and explore the mechanism about the anti-NTHi infection.The C57BL/6 mice intranasally immunized with purified Hap recombinant protein and CT-B were challenged by NTHi encased in agar beads.
Wan-yi, Li, Bao-ning, Wang, Feng-qiong, Zuo, Wei, Zeng, Feng, Feng, Yu, Kuang, Zhong-hua, Jiang, Ming-yuan, Li   +7 more
openaire   +2 more sources

Increased total, secretory and NTHi-specific IgA in the COPD airway

10.1 Respiratory Infections, 2015
Non-typeable Haemophilus influenzae (NTHi) can colonise the COPD airway. Previous work has suggested that the ability of NTHi to survive is due to deficient release of secretory (s)IgA into the airway lumen1. The aim of our study (NCT01701869) was to quantify the amount and functionality of IgA in bronchoalveolar lavage (BAL).
Karl J. Staples, Stephen Taylor, Steve Thomas, Kristoffer Ostridge, Alice Richardson, Andrew C. Tuck, Stuart C. Clarke, Andrew Gorringe, Tom M.A. Wilkinson   +8 more
openaire   +1 more source

Cytotoxic responses of mucosal-associated Invariant T cells to NTHi infection

10.1 Respiratory Infections, 2016
The airways of patients with COPD are commonly colonised by non-typeable Haemophilus influenzae (NTHi). Despite being increased in the COPD airway, CD8+ T cells appear unable to clear NTHi infection, contributing to exacerbations of COPD and promoting disease progression. The CD8+ population in the lung includes recently discovered mucosal-associated
Joshua Wallington, Anthony P. Williams, Karl J. Staples, Tom M.A. Wilkinson   +3 more
openaire   +1 more source

Nontypeable haemophilus influenzae (NTHi) and lung oxidative stress

European Respiratory Journal, 2013
Background: COPD is characterized by ongoing airway inflammation that continues after smoking cessation. The production of reactive oxygen species (ROS) to produce oxidative stress and lung damage is a key feature of this ongoing inflammatory process. The lung phagocytes (macrophages and neutrophils) are thought
Jyotika Prasad, Steven Lim, Nagmeh Radhakrishna, Peter Maclaughlin, Michael Farmer, Daniel Steinfort, Stavros Selemidis, Philip Bardin, Stephen Holdsworth, Peter Holmes, Paul King   +10 more
openaire   +1 more source

Efficacy of dexamethasone, roflumilast and azithromycin in a murine cigarette smoke/NTHi infection model

10.1 Respiratory Infections, 2016
Background: Smoking is a central risk factor for the development of Chronic Obstructive Pulmonary Disease (COPD) and Nontypeable Haemophilus Influenzae (NTHi) is expected to be an important trigger of exacerbations. Steroids, PDE-4 inhibitors and macrolides are used as treatment options.
Hannes Bucher, Birgit Jung, Klaus J. Erb
openaire   +1 more source

Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells

Microbes and Infection, 2017
Loss of epithelial barriers characterized by reduction of E-cadherin is a hallmark of chronic obstructive pulmonary disease (COPD). We investigated the effects of nontypeable Haemophilus influenzae (NTHi) infections, associated with acute exacerbations of chronic bronchitis, on the regulation of E-cadherin in host cells.
Jan Rupp, Goldmann T, Sebastian Marwitz   +2 more
exaly   +3 more sources

NTHi-induced inflammation activates the PD-1 immune checkpoint in the tumor microenvironment

Lung Cancer, 2018
Background: Microbial colonization contributes to chronic neutrophilic inflammation in COPD. Nontypeable Haemophilus influenzae (NTHi) is frequently found in lungs of stable COPD patients and is the major pathogen triggering exacerbations. Immune-checkpoint inhibitors, such as antibodies targeting the PD-1/PD-L1 axis, have demonstrated efficacy as ...
Felix Ritzmann, Giovanna Vella, Christrian Herr, Robert Bals, Christoph Beisswenger   +4 more
openaire   +1 more source