Results 121 to 130 of about 10,598 (216)

Analysis of NTRK expression in gastric and esophageal adenocarcinoma (AGE) with pan-TRK immunohistochemistry

, 2019
Small molecule inhibitors such as Larotrectinib have been recently approved in the treatment of patients with fusions of the neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) genes 1-3.
Treese, C., Daum, S., Horst, D., von Winterfeld, M., Stein, U., Hummel, M., Rau, B., Arnold, A., Berg, E.   +8 more
core   +1 more source

Mutation of neurotrophic tyrosine receptor kinase can promote pan-cancer immunity and the efficacy of immunotherapy

Molecular Cancer
The Neurotrophic tyrosine receptor kinase (NTRK) family plays important roles in tumor progression and is involved in tumor immunogenicity. Here, we conducted a comprehensive bioinformatic and clinical analysis to investigate the characteristics of NTRK ...
Congren Wang, Yingying Li, Jinyuan Huang, Huimeng Yan, Bin Zhao   +4 more
doaj   +1 more source

NTRK gene fusion testing and management in lung cancer.

Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are recurrent oncogenic drivers found in a variety of solid tumours, including lung cancer. Several tropomyosin receptor kinase (TRK) inhibitors have been developed to treat tumours with NTRK gene
Loong, H.H., Drilon, A, Zhou, C, Lopez-Rios, F., Chiara Garassino, M., Rudzinski, ER, Loong, HH, Mok, T, Planchard, D., Popat, S, Repetto, M., Lopez-Rios, F, Popat, S., Chiara Garassino, M, Zhou, C., Repetto, M, Peters, S., Mok, T., Drilon, A., Rudzinski, E.R., Peters, S, Planchard, D   +21 more
core   +1 more source

Standardization of a tissue microarray design for immunohistochemical detection of NTRK gene fusion proteins in a solid tumors series

, 2021
ilustraciones, fotografías a color, gráficas, tablasLos genes NTRK participan en la expresión de receptores tirosina kinasa, los cuales participan en la diferenciación, desarrollo y regulación del sistema nervioso. Las fusiones en estos genes constituyen
Londoño Rojas, Erika Alessandra
core  

Nöroblastomlarda nörotrofik reseptör tirozin kinaz (NTRK)'nın öneminin araştırılması

Nöroblastom (NB), pediatrik kanserler arasında en sık rastlanan ekstrakraniyal solid tümördür ve çocukluk çağı kanser ölümlerinin %15'inden sorumludur. Nörotrofik reseptör tirozin kinazlar (NTRK), sinir sisteminin gelişimi ve fonksiyonunda kritik roller ...
NURIYA ISMAYIL
core  

Larotrectinib in a NTRK-rearranged soft tissue sarcoma in the neoadjuvant setting: a case report

, 2020
NTRK gene-fusions are rare but can occur in diverse cancers. The NTRK inhibitor larotrectinib is newly approved by the FDA. This paper reports the first case of a man with a NTRK-rearranged soft tissue sarcoma treated with larotrectinib in the ...
Kirchgesner, Thomas, Schubert, Thomas, Mazzeo, Filomena, Percy, Catherine, Galant, Christine   +4 more
core  

Targeting wild type NTRK decreases brain metastases of lung cancers non-driven by NTRK fusions

ABSTRACT The central nervous system (CNS) is a common site of metastatic spread for both non-small cell and small cell lung cancer, yet the therapeutic strategies to prevent and decrease lung cancer brain metastases remain limited.
Maria J. Contreras-Zárate, Jenny A. Jaramillo-Gómez, R. Alejandro Marquez-Ortiz, Trinh C. Pham, Stella Koliavas, D. Ryan Ormond, Andre C. Navarro, Raphael A Nemenoff, D. Ross Camidge, Diana M. Cittelly   +9 more
openaire   +2 more sources

Evaluation of NTRK Fusions Detection Method in Esophageal Squamous Cell Carcinoma and Gastric Adenocarcinoma

Neurotrophic tyrosine receptor kinase (NTRK) fusions function as oncogenes and have been targeted by TRK inhibitors with excellent clinical outcomes.
Ken Miyabe, Hiroyuki Hanayama, Shotaro Nakajima, Motonobu Saito, Zenichiro Saze, Yusuke Sato, Akiteru Goto, Kouya Shiraishi, Tomoyuki Momma, Hirokazu Okayama, Katsuharu Saito, Kosaku Mimura, Koji Kono, Erika Machida, Naoto Tsuchiya   +14 more
core   +1 more source

110P Updated efficacy and safety of entrectinib in patients (pts) with NTRK fusion-positive (NTRK-fp) NSCLC

Annals of Oncology, 2022
B.C. Cho, C-H. Chiu, E. Massarelli, S.P. Chawla, G.L. Buchschacher, K. Goto, S-W. Kim, T.R. Overbeck, H.H.F. Loong, C.E. Chee, P. Garrido, S. Heinzmann, B. Pitcher, T. John   +13 more
openaire   +2 more sources

Data from Targeting Wild-type <i>NTRK</i> in <i>NTRK</i> Fusion–Negative Lung Cancer Decreases Brain Metastases

<div>Abstract <p>The central nervous system (CNS) is a common site of metastasis for both non–small cell and small cell lung cancer, yet the therapeutic strategies to prevent and decrease lung cancer brain metastases (BM) remain limited ...
Diana M. Cittelly, D. Ryan Ormond, R. Alejandro Marquez-Ortiz, Raphael A. Nemenoff, D. Ross Camidge, Maria J. Contreras-Zárate, Jenny A. Jaramillo-Gómez, Stella N. Koliavas, Andre C. Navarro, Trinh C. Pham   +9 more
core   +1 more source