Results 181 to 190 of about 9,316 (206)
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RET and NTRK1 proto‐oncogenes in human diseases
Journal of Cellular Physiology, 2003AbstractRET and NTRK1 are receptor tyrosine kinase (RTK) proteins which play a role in the development and maturation of specific component of the nervous system. Their alterations have been associated to several human diseases, including some forms of cancer and developmental abnormalities.
Luisella, Alberti +4 more
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Cancer Research
Abstract Treatment of non–small cell lung cancer (NSCLC) has drastically changed in recent years owing to the robust anticancer effects of immune checkpoint inhibitors (ICI). However, only 20% of the patients with NSCLC benefit from ICIs, highlighting the need to uncover the mechanisms ...
Margaret R. Smith +19 more
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Abstract Treatment of non–small cell lung cancer (NSCLC) has drastically changed in recent years owing to the robust anticancer effects of immune checkpoint inhibitors (ICI). However, only 20% of the patients with NSCLC benefit from ICIs, highlighting the need to uncover the mechanisms ...
Margaret R. Smith +19 more
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EPS15–NTRK1: a novel NTRK1 oncogenic fusion in patient with lung adenocarcinoma
Journal of Cancer Research and Clinical Oncology, 2020Shengzhuang Yang +4 more
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Genomic organization of the human NTRK1 gene.
Oncogene, 1997The NTRK1 gene encodes one of the receptors for the Nerve Growth Factors and it is located at 1q21-22. Rearrangements of NTRK1 are frequently detected in human papillary thyroid carcinoma and lead to the formation of chimeric oncogenes, similarly to what observed for the other neurotrophin receptor RET. In addition, the two receptor genes are target of
A, Greco, R, Villa, M A, Pierotti
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The American Journal of Dermatopathology
Abstract: Over the past decade, advancements in molecular biology have contributed to changes in the diagnostic classification of Spitz neoplasms, including Spitz nevi, atypical Spitz tumors, and Spitz melanomas. The recent World Health Organization classification of skin tumors identifies fusion kinases, including NTRK1, NTRK2, and NTRK3, as
Gerardo Cazzato +8 more
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Abstract: Over the past decade, advancements in molecular biology have contributed to changes in the diagnostic classification of Spitz neoplasms, including Spitz nevi, atypical Spitz tumors, and Spitz melanomas. The recent World Health Organization classification of skin tumors identifies fusion kinases, including NTRK1, NTRK2, and NTRK3, as
Gerardo Cazzato +8 more
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NTRK1 Spitz melanoma presenting clinically as an angioma
International Journal of Dermatology, 2023Audelia, Arasheben +6 more
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Rearrangements of NTRK1 oncogene in papillary thyroid carcinoma.
Neuro endocrinology letters, 2008Papillary thyroid carcinoma (PTC) represents an example of tumour with high incidence of oncogenic sequences, such as RET/PTC and Trk. Both of them arise from the fusion of 3' terminal sequences of TK domain of RET or NTRK1 gene, respectively, with 5' terminal sequences of their activating genes.
Ewa, Brzeziańska +2 more
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Cost-Efficient Detection of NTRK1/2/3 Gene Fusions: Single-Center Analysis of 8075 Tumor Samples
International Journal of Molecular Sciences, 2023Aglaya Iyevleva +2 more
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