Results 101 to 110 of about 6,777,214 (229)

MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements

Cancer Medicine, 2023
Background Entrectinib is an effective drug for treating solid tumors with NTRK gene rearrangement and non‐small cell lung cancer (NSCLC) with ROS1 gene rearrangement.
Yohei Takumi, Sachiko Arai, Chiaki Suzuki, Koji Fukuda, Akihiro Nishiyama, Shinji Takeuchi, Hiroki Sato, Kunio Matsumoto, Kenji Sugio, Seiji Yano   +9 more
doaj   +1 more source

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, Volume 117, Issue 1, Page 156-168, January 2026.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

The Cancer Genomics Resource List 2014 [PDF]

, 2014
Context.— Genomic sequencing for cancer is offered by commercial for-profit laboratories, independent laboratory networks, and laboratories in academic medical centers and integrated health networks. The variability among the tests has created a complex,
Bloom, Kenneth J., Cheng, Liang, Hagemann, Ian S., Kaufman, Jill H., Krasinskas, Alyssa M., Lazar, Alexander J., Leonard, Debra G. B., Lindeman, Neal I., Moyer, Ann M., Nikiforova, Marina N., Nowak, Jan A., Pfeifer, John D., Sepulveda, Antonia R., Willis, Joseph E., Yohe, Sophia L., Zutter, Mary M.   +15 more
core   +1 more source

Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing

Clinical Endocrinology, Volume 104, Issue 1, Page 67-74, January 2026.
ABSTRACT Objective The 2023 Bethesda System update introduced molecular testing as a management option for Bethesda V cytology nodules, aiming to guide surgical decision‐making. This study investigates the correlation between molecular profiling and malignancy aggressiveness. Design We conducted a retrospective multicenter study involving patients with
Idit Tessler, Grégoire B. Morand, Nir A. Gecel, Arad Dotan, Tzahi Yamin, Eran E. Alon, Richard J. Payne, Galit Avior   +7 more
wiley   +1 more source

Lipofibromatosis-like neural tumor: Case report of a unique infantile presentation

JAAD Case Reports, 2018
A 14-month-old boy presented with a slow-growing, asymptomatic back plaque, which was biopsied and found to have S100 positivity, sparse CD34 staining, and no significant mitotic activity, nuclear pleomorphism, or necrosis; genetic workup found LMNA ...
Diana W. Bartenstein, BA, Taylor M. Coe, MD, Samantha C. Gordon, MD, Alison M. Friedmann, MD, Maryanne M. Senna, MD, Cassandra M. Kelleher, MD, Cristina R. Antonescu, MD, Rosalynn M. Nazarian, MD, Elena B. Hawryluk, MD, PhD   +8 more
doaj   +1 more source

Decreased Pain Severity and Differential Gene Expression Following Calmare Therapy [PDF]

, 2015
We present the results of a double-blinded randomized sham-controlled research study of a non-pharmacologic low back pain intervention. Calmare therapy is an neurocutanous electrical stimulation approach for pain management.
Heineman, Amy, Petraco, Jeffrey, Starkweather, Angela R.   +2 more
core   +1 more source

Use of q-values to Improve a Genetic Algorithm to Identify Robust Gene Signatures [PDF]

Several approaches have been proposed for the analysis of DNA microarray datasets, focusing on the performance and robustness of the final feature subsets.
Chambers, SJ, Franco, L, Jarman, I, Jerez, JM, Lisboa, P, Urda, D   +5 more
core   +1 more source

Single-cell RNAseq reveals seven classes of colonic sensory neuron. [PDF]

, 2018
OBJECTIVE: Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but the diversity ...
Bach, Karsten, Bulmer, David C, Callejo, Gerard, Gutteridge, Alex, Hockley, James RF, McMurray, Gordon, Smith, Ewan St John, Taylor, Toni S, Wilbrey, Anna L, Winchester, Wendy J   +9 more
core   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

c.1810C>T Polymorphism of NTRK1 Gene is associated with reduced Survival in Neuroblastoma Patients

BMC Cancer, 2009
Background TrkA (encoded by NTRK1 gene), the high-affinity tyrosine kinase receptor for neurotrophins, is involved in neural crest cell differentiation.
Chybicka Alicja, Perek Danuta, Balcerska Anna, Ziętkiewicz Szymon, Iżycka-Świeszewska Ewa, Tonini Gian, Scaruffi Paola, Drożynska Elżbieta, Lipska Beata S, Biernat Wojciech, Limon Janusz   +10 more
doaj   +1 more source