Results 1 to 10 of about 9,316 (206)

NTRK1 fusion in glioblastoma multiforme. [PDF]

PLoS ONE, 2014
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy with substantial survival benefit. Recent studies on solid tumors showed that fusion genes often play driver roles and are promising targets for ...
Jinkuk Kim, Yeri Lee, Hee Jin Cho, Young-Eun Lee, Jaeyeol An, Gye-Hyun Cho, Young-Hyeh Ko, Kyeung Min Joo, Do-Hyun Nam   +8 more
doaj   +5 more sources

Novel NOTCH2-NTRK1 fusion confers osimertinib resistance in EGFR-mutant non-small cell lung cancer by interacting with EGFR [PDF]

Translational Oncology
Background: Overcoming osimertinib resistance in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) is challenging due to unclear mechanisms. We previously reported a NSCLC case with EGFR mutations progressed on osimertinib
Hui Li, Huiting Wei, Tiantian Zhen, Huabin Gao, Huicong Liu, Shuai Zheng, Huijuan Shi, Jiangtao Liang, Fenfen Zhang, Jiecheng Ye, Gengpeng Lin, Anjia Han   +11 more
doaj   +3 more sources

Not all NTRK fusions in mesenchymal neoplasia are driver events: implications on classification and targeted therapy. [PDF]

J Pathol Clin Res
Abstract NTRK fusions drive the pathogenesis of a distinctive group of mesenchymal neoplasms with significant impact on classification and targeted therapy. However, unexpected NTRK fusions have been reported in other sarcoma entities, raising uncertainty over their specificity and clinical management.
Yakoub MA, Sukhadia P, Saoud C, Hameed M, Antonescu CR.   +4 more
europepmc   +2 more sources

Novel deep intronic variants in NTRK1 underlying congenital insensitivity to pain with anhidrosis [PDF]

Frontiers in Genetics
ObjectivesCongenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder caused by mutations in NTRK1 that is characterized by pain insensitivity, anhidrosis, and recurrent fever. While genetic testing is the gold standard
Xin Chen, Xin Chen, Shuang Li, Shuang Li, Zhe Liu, Jian Cheng, Xiuzhi Ren, Xiuli Zhao, Xiuli Zhao, Xiuli Zhao   +9 more
doaj   +2 more sources

Acquired TPM3::NTRK1 fusion as a novel off-target resistance mechanism to selpercatinib in RET-positive lung adenocarcinoma: a case report [PDF]

Frontiers in Oncology
Acquired resistance remains a major challenge in RET fusion-positive non-small cell lung cancer treated with selective RET inhibitors. NTRK fusions represent a rare off-target resistance mechanism in this setting, with limited clinical data to guide ...
Ritwika Choudhury, Mansi Sharma, Abhinav Dewan, Sabeena K. Choudhary, Priyanka Venkatraman, Vivek Subbiah, Ullas Batra   +6 more
doaj   +2 more sources

Investigation of a Novel NTRK1 Variation Causing Congenital Insensitivity to Pain With Anhidrosis

Frontiers in Genetics, 2021
Background: Congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive sensory neuropathy, was caused mainly by biallelic mutations in the NTRK1 gene.
Huaying Hu, Kai Yang, Yong-Qing Sun
exaly   +3 more sources

LMNA-NTRK1-rearranged spindle cell neoplasm with multiple relapses: a case report and literature review [PDF]

Frontiers in Medicine
Neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasms (NTRK-RSCNs) constitute a rare, heterogeneous subset of soft tissue tumors defined by oncogenic fusions involving NTRK1, NTRK2, or NTRK3 genes. Despite the remarkable efficacy
Yinan Zhu, Ziyue Wang, Haiyan Xi, Wanchen Lu, Mingfang Sun, Xuyong Lin   +5 more
doaj   +2 more sources

A novel NTRK1 splice site variant causing congenital insensitivity to pain with anhidrosis in a Chinese family

Frontiers in Genetics
BackgroundCongenital insensitivity to pain with anhidrosis (CIPA, OMIM #256800), also known as hereditary sensory and autonomic neuropathy type Ⅳ (HSAN-IV), is a rare autosomal recessive disorder characterized by recurrent episodic fevers, anhidrosis ...
Ling Sun, Jin Dai, Yuan Zhang, Yuan Zhang, Lijun Zhou, Lijun Zhou, Yaqiong Ren, Yaqiong Ren, Hongying Wang, Hongying Wang, Hongying Wang   +10 more
exaly   +3 more sources

NTRK fusions and concomitant immune and genomic landscape detected by DNA and RNA comprehensive genomic profiling in a large healthcare system [PDF]

Frontiers in Medicine
IntroductionThe use of next-generation sequencing (NGS) in clinical investigations has enabled the identification of actionable biomarkers across tumor histologies, paving the way for the development of pan-tumor therapies.
Alexa K. Dowdell, Alexa K. Dowdell, Thomas R. Ward, Lauren T. Hamilton, Lauren T. Hamilton, Roshanthi K. Weerasinghe, Erica Schnettler, Pratheesh Sathyan, Alison Roos, Josiah T. Wagner, John Welle, Ryan C. Meng, Ryan C. Meng, Alexandra Q. Bartlett, Alexandra Q. Bartlett, Carlo B. Bifulco, Carlo B. Bifulco, Brian D. Piening, Brian D. Piening   +18 more
doaj   +2 more sources

Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines [PDF]

PeerJ, 2023
Background NTRK1 gene, encoding TrkA, is essential for the nervous system and drives a variety of biological processes, including pain. Given the unsatisfied analgesic effects of some new drugs targeting NTRK1 in clinic, a deeper understanding for the ...
Bo Jiao, Mi Zhang, Caixia Zhang, Xueqin Cao, Baowen Liu, Ningbo Li, Jiaoli Sun, Xianwei Zhang   +7 more
doaj   +2 more sources