Results 41 to 50 of about 9,316 (206)

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Nothobranchius furzeri

Brain Sciences, 2020
Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons.
Paolo de Girolamo, Adele Leggieri, Antonio Palladino, Carla Lucini, Chiara Attanasio, Livia D’Angelo   +5 more
doaj   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Phenotypic heterogeneity of intellectual disability in patients with congenital insensitivity to pain with anhidrosis: A case report and literature review

Journal of International Medical Research, 2018
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive heterogeneous disorder mainly caused by mutations in the neurotrophic tyrosine receptor kinase 1 gene ( NTRK1 ) and characterized by insensitivity to noxious stimuli ...
Zhenlei Liu, Jiaqi Liu, Gang Liu, Wenjian Cao, Sen Liu, Yixin Chen, Yuzhi Zuo, Weisheng Chen, Jun Chen, Yu Zhang, Shishu Huang, Guixing Qiu, Philip F. Giampietro, Feng Zhang, Zhihong Wu, Nan Wu   +15 more
doaj   +1 more source

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer [PDF]

Nature Medicine, 2013
We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein). Both the MPRIP-NTRK1 and CD74-NTRK1 fusions lead to constitutive TRKA kinase activity and are oncogenic. Treatment of cells expressing NTRK1 fusions with inhibitors of TRKA
Vaishnavi, A., Capelletti, M., Le, A.T., Kako, S., Butaney, M., Ercan, D., Mahale, S., Davies, K.D., Aisner, D.L., Pilling, A.B., Berge, E.M., Kim, J., Sasaki, H., Park, S., Kryukov, G., Garraway, L.A., Hammerman, Peter S., Haas, J., Andrews, S.W., Lipson, D., Stephens, P.J., Miller, V.A., Varella-Garcia, M., Jänne, P.A., Doebele, R.C.   +24 more
openaire   +2 more sources

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

BCAN-NTRK1 fusion.

, 2014
(A) Per-nucleotide read coverage of genomic regions along BCAN and NTRK1. The dotted line marks approximate positions where the fusion has occurred. (B) A schematic of spliced transcripts of the fusion gene.
Hee-Jin Cho (539376), Do-Hyun Nam (184130), Jinkuk Kim (539374), Gye-Hyun Cho (539378), Kyeung Min Joo (184093), Young-Hyeh Ko (521737), Young-Eun Lee (296048), Jaeyeol An (539377), Yeri Lee (539375)   +8 more
core   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer [PDF]

, 2015
IntroductionChromosomal rearrangements involving neurotrophic tyrosine kinase 1 (NTRK1) occur in a subset of non-small cell lung cancers (NSCLCs) and other solid tumor malignancies, leading to expression of an oncogenic TrkA fusion protein.
Lim, Jonathan E, Iafrate, Anthony J, Chow-Maneval, Edna, Shaw, Alice T, Patel, Manish, Iafrate, Anthony J., Le, Long P, Costa, Daniel B., Costa, Daniel B, Hornby, Zachary, Lim, Jonathan E., Jackman, David, Muzikansky, Alona, Li, Gary G., Farago, Anna F, Zheng, Zongli, Ou, Sai-Hong I, Liu, Stephen V., Luo, David, Drilon, Alexander, Ou, Sai-Hong I., Bauer, Todd M., Multani, Pratik S, Bauer, Todd M, Shaw, Alice T., Liu, Stephen V, Li, Gary G, Farago, Anna F., Le, Long P., Multani, Pratik S.   +29 more
core   +1 more source

Novel mutations in Chinese patients with congenital insensitivity to pain with anhidrosis

Molecular Pain, 2018
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder, characterized by loss of algesthesis and inability to sweat. CIPA is known to be caused by mutations in the neurotrophic tyrosine kinase receptor type 1 gene (
Xingzhu Geng, Yanshan Liu, XiuZhi Ren, Yun Guan, Yanzhou Wang, Bin Mao, Xiuli Zhao, Xue Zhang   +7 more
doaj   +1 more source