Results 71 to 80 of about 9,316 (206)

STRN3-NTRK1: A Novel NTRK1 Oncogenic Fusion in a Patient with Lung Adenocarcinoma [PDF]

open access: yesJournal of Thoracic Oncology, 2020
Rongguo Lu   +4 more
openaire   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

open access: yesThe Journal of Pathology, Volume 270, Issue 1, Page 23-39, September 2026.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps   +3 more
wiley   +1 more source

Final Analysis of Neoadjuvant Sintilimab Plus Chemotherapy in IB–IIIA Non‐Small‐Cell Lung Cancer: Phase 2 neoSCORE Trial

open access: yesCancer Science, Volume 117, Issue 9, Page 2509-2520, September 2026.
Kaplan–Meier survival curves comparing two‐cycle versus three‐cycle neoadjuvant sintilimab plus chemotherapy. (A) Disease‐free survival (DFS). (B) Overall survival (OS). CI, confidence interval; HR, hazard ratio; NR, not reached. ABSTRACT The optimal number of neoadjuvant chemoimmunotherapy cycles for resectable non‐small cell lung cancer (NSCLC ...
Miner Shao   +13 more
wiley   +1 more source

More Than a Birthmark? A Growing Pediatric Skin Lesion

open access: yes
JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj   +2 more
wiley   +1 more source

Radioiodine‐Refractory Differentiated Thyroid Cancer: Definition, Molecular Mechanisms, and Advances in Precision Therapy

open access: yesCancer Innovation, Volume 5, Issue 4, August 2026.
Radioiodine‐refractory differentiated thyroid cancer (RAIR‐DTC) management now spans selective kinase inhibitors, MAPK‐pathway redifferentiation, VEGFR multikinase TKIs, and biomarker‐driven immunotherapy. We propose a three‐axis decision framework integrating molecular driver, evidence level, and patient dimension to guide individualized treatment ...
Yamin Li, Zuoxiang He
wiley   +1 more source

Supplementary Figures S1-S11 and Table from Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers

open access: yes, 2017
Supplementary FigureS1: Sensitivity of TPM3†NTRK1 Ba/F3 clones to various NTRK1 inhibitors; Supplementary FigureS2: Sensitivity of TPM3†NTRK1 G595R mutant Ba/F3 cells to various NTRK1 inhibitors; Supplementary Figure S3: Sensitivity of TPM3â ...
Naoya Fujita (448838)   +5 more
core   +1 more source

DataSheet1_Investigation of a Novel NTRK1 Variation Causing Congenital Insensitivity to Pain With Anhidrosis.CSV

open access: yes, 2021
Background: Congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive sensory neuropathy, was caused mainly by biallelic mutations in the NTRK1 gene.
Hua-Ying Hu (11797217)   +10 more
core   +1 more source

MEIS1::NCOA2 Rearranged Spindle Cell Neoplasm of Vulva With Unusual Low‐Grade Morphology

open access: yesGenes, Chromosomes and Cancer, Volume 65, Issue 8, August 2026.
ABSTRACT MEIS1::NCOA2 is a recurrent gene fusion that has been predominantly identified in primitive sarcomas arising within the genitourinary and gynecological tracts. Since its initial description in 2018, an increasing number of cases have been reported, further defining the clinicopathological spectrum of this entity.
Pinki Soni   +6 more
wiley   +1 more source

A subset of high‐grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions

open access: yesThe Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Maximus CF Yeung   +4 more
wiley   +1 more source

DataSheet3_Investigation of a Novel NTRK1 Variation Causing Congenital Insensitivity to Pain With Anhidrosis.PDF

open access: yes, 2021
Background: Congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive sensory neuropathy, was caused mainly by biallelic mutations in the NTRK1 gene.
Hua-Ying Hu (11797217)   +10 more
core   +1 more source

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