Results 61 to 70 of about 9,316 (206)

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

NTRK1-rearranged histiocytosis: clinicopathologic and molecular features

Blood Advances
Abstract Non-Langerhans cell histiocytoses are a diverse group of histiocytic diseases. Different entities are defined based on clinical, histopathologic, and/or molecular characteristics. This study aimed to define NTRK-rearranged histiocytosis.
Rivers Fragneau, Sylvie Fraitag, Paul G. Kemps, Zofia Hélias-Rodzewicz, Somak Roy, Benjamin Bonsang, Allison L. Bartlett, Subhra Dhar, Martin Jankofsky, Jozef Zlocha, Karel Svojgr, Lenka Krsková, Andrica C. H. de Vries, Robert M. Verdijk, Jan A. M. van Laar, Roos J. Leguit, Philippe Drabent, Eric D. Carlsen, Jonhan Ho, Arivarasan D. Karunamurthy, Mariarita Santi, Marie-Laure Jullié, Florian Babor, Robert Lorsbach, Astrid G. S. van Halteren, Sébastien Héritier, Eli L. Diamond, Benjamin H. Durham, Ashish R. Kumar, Arunaloke Bhattacharya, Julien Haroche, Jean Donadieu, Arndt Borkhardt, Jennifer L. Picarsic, Jean-François Emile   +34 more
openaire   +4 more sources

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers

, 2017
Neurotrophic receptor tyrosine kinase 1 (NTRK1) gene rearrangement leads to constitutive activation of NTRK1, which induces high-transforming ability. NTRK-rearranged cancers have been identified in several cancer types, such as glioblastoma, non–small ...
Naoya Fujita, Miho J. Fuse, Koutaroh Okada, Tomoko Oh-hara, Hayato Ogura, Ryohei Katayama   +5 more
core   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini, Ludovica Donadini, Pritha Dey, Federica Franciosi, Valentina Lodde, Maria Belen Rabaglino, Alberto Maria Luciano   +6 more
wiley   +1 more source

NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer

, 2016
The identification and clinical validation of cancer driver genes are essential to accelerate the translational transition of cancer genomics, as well as to find clinically confident targets for the therapeutic intervention of cancers. Here we identified
Shin, Jong-Yeon, Park, Hee Dong, Lee, Ji Shin, Park, Ok Ku, Choi, Chan, Park, Joonghoon, Kwon, Chae Hwa, Park, Eok, Lee, Jae Hyuk, Shin, Eunji, Kim, Hyun Sung, Kim, Hyeong-Rok, Oh, Nahmgun, Park, Jonghoon, Kim, Jong-Il, Park, Do Youn, Jo, Hong-Jae, Seo, Jeong-Sun   +17 more
core   +1 more source

Novel pathogenic mechanisms of CIPA genetic disorder unveiled by functional analysis of NTRK1/NGF receptor mutations

, 2002
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare genetic disease characterized by absence of reaction to noxious stimuli and anhidrosis. The genetic bases of CIPA have remained long unknown.
SELLERI S, Pagliardini, S., GRECO A., MIRANDA C, Pierotti, M.A., ZANOTTI, GIUSEPPE, DIO VIRGILIO M, PIEROTTI M. A, Miranda, C., Selleri, S., Greco, A., Di Virgilio, M., Zanotti, G., PAGLIARDINI S   +13 more
core   +1 more source

Generalized eruptive histiocytosis associated with a novel fusion in LMNA-NTRK1 [PDF]

, 2016
Non-Langerhans cell histiocytosis (NLCH) is a histiocyte disorder comprised of dermal dendritic histiocytes with a characteristic staining pattern.
Jahan-Tigh, Richard R, Chon, Susan, Pinney, Sarah S   +2 more
core   +1 more source

Correction: NTRK1 Fusion in Glioblastoma Multiforme

PLoS ONE, 2014
doaj   +4 more sources