Results 81 to 90 of about 9,316 (206)
, 2019 Ningbo Li,1 Shanna Guo,1 Qingli Wang,2 Guangyou Duan,3 Jiaoli Sun,1 Yi Liu,1 Jin Zhang,1 Cong Wang,1 Changmao Zhu,1 Jingyu Liu,4 Xianwei Zhang1 1Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and ...
Liu Y +10 more
core
Congenital Insensitivity to Pain with Anhidrosis in an Iranian Patient
Basic and Clinical Neuroscience, 2013 Congenital insensitivity to pain with anhidrosis is a rare disease of the nervous system which causes one to lose his/her feeling of pain. The disease is subtype four of hereditary sensory and autonomic neuropathy (HSAN IV) that results from NTRK1 gene ...
Nasrollah Saleh-gohari +1 more
doaj +2 more sources
Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer
, 2019 The implementation of cancer immunotherapeutics for solid tumors including lung cancers has improved clinical outcomes in a small percentage of patients.
Rosalba Minelli +11 more
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BMC Cancer, 2019 Background Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonary SC develops and progresses. Case
Jianjun Ge +7 more
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Tumorigenic activities of NFASC-NTRK1 fusion gene.
, 2014 (A) NFASC-NTRK1 and EGFR vIII mRNA expression in NIH 3T3 cells, determined by RT-PCR. (B) Proliferation of NIH 3T3 cells lentivirally infected with the indicated viruses. Error bars are 95% confidence intervals.
Hee-Jin Cho (539376) +8 more
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List of drugs that target NTRK1.
Human kinases play essential and diverse roles in the cellular activities of maintaining homeostasis and growth. Genetic mutations in the genes encoding the kinases (or phosphotransferases) have been linked with various types of cancers.
Muhammad Shakeel (509491) +6 more
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NTRK1 Gene Fusions Are Frequent in Juvenile Xanthogranuloma
American Journal of Surgical PathologyJuvenile Xanthogranuloma (JXG) is a rare form of non-Langerhans cell histiocytosis. The most common known gene mutations affect the mitogen-activated protein (MAP) kinase, phosphoinositide 3-kinase (PI3K), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways.
Elisabeth Schlögl +9 more
openaire +2 more sources
Frontiers in Microbiology, 2018 Ebolavirus (EBOV) life cycle involves interactions with numerous host factors, but it remains poorly understood, as does pathogenesis. Herein, we synthesized 65 siRNAs targeting host genes mostly connected with aspects of the negative-sense RNA virus ...
Dong-Shan Yu +17 more
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, 1996 Oncogenic rearrangements of RET and NTRK1 proto-oncogenes are frequently detected in papillary thyroid carcinomas. Several studies have shown an association between ionizing radiation and development of this tumor type.
Pinchera A +9 more
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NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas
Pathology and Oncology ResearchThe neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins.
Zoltán Lippai +5 more
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