Results 91 to 100 of about 9,316 (206)

NTRK1-3 point mutations in poor prognosis thyroid cancers.

, 2017
6087 Background: NTRK1-3 fusions, identified in pediatric radiation-associated thyroid cancers, are low frequency oncogenic drivers that can trigger constitutive activation of TrK1-3 tyrosine kinase domains with responsively heightened downstream ...
Ashish V. Chintakuntlawar, Nicole M. Iniguez-Ariza, Vijayalakshmi Shridhar, Eric Allan Severson, Michael E. Menefee, Mabel M Ryder, Crystal Hilger, John C. Morris, Keith Christopher Bible, Robert C. Smallridge   +9 more
core   +1 more source

The Autocrine Impact of Nerve Growth Factor on Sheep Uterine Epithelial Cells

Cells
Nerve growth factor (NGF) plays a critical role in reproduction through paracrine and endocrine mechanisms. However, its autocrine effects on uterine receptivity and inflammatory pathways remain unknown.
Gabriella Guelfi, Rolando Pasquariello, Cecilia Dall’Aglio, Francesca Mercati, Chiara Suvieri, Carmela Conte, Camilla Capaccia, Marcelo Ratto, Margherita Maranesi   +8 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Analysis of NTRK1 gene rearrangement and BRAF gene mutation in papillary thyroid carcinoma

, 2004
Activating mutations of genes coding for two different tyrosine kinase receptor, either RET or NTRK1 (also named TRKA), as well as of RAS or BRAF gene are associated with human thyroid papillary carcinoma (PTC).
Li, Chun-Liang
core  

Whole exome sequencing in congenital pain insensitivity identifies a novel causative intronic NTRK1-mutation due to uniparental disomy.

, 2016
Congenital insensitivity to pain and anhidrosis (CIPA), also known as hereditary sensory and autonomic neuropathy type IV (HSAN IV), is characterized by recurrent episodes of unexplained high fever, loss of pain perception and temperature sensation ...
Kurth, Ingo;Baumgartner, Manuela;Schabhüttl, Maria;Tomni, Cecilia;Windhager, Reinhard;Strom, Tim M;Wieland, Thomas;Gremel, Kurt;Auer-Grumbach, Michaela
core   +2 more sources

Abstract LB-123: Identification of the molecular mechanisms of resistance to NTRK inhibitors and the potential therapeutic strategies in NTRK1-rearranged cancers

, 2017
Neurotrophic receptor tyrosine kinase 1 (NTRK1) gene rearrangement leads to constitutive activation of NTRK1, which induces high transforming ability. NTRK-rearranged cancers have been identified in several cancer types, such as glioblastoma, non-small ...
Naoya Fujita, Miho J. Fuse, Tomoko Oh-hara, Hayato Ogura, Ryohei Katayama   +4 more
core   +1 more source

N of 2 Responders With LMNA-NTRK1 [PDF]

JNCI: Journal of the National Cancer Institute, 2015
Chih-Jian, Lih, Alice P, Chen
openaire   +2 more sources

NTRK-rearranged spindle cell neoplasm of the female genital tract: case report and literature review

Frontiers in Oncology
NTRK-rearranged spindle cell neoplasm is a rare subtype of soft tissue sarcoma that occasionally arises in the lower female genital tract. Accurate diagnosis is clinically important, as these tumors generally display low-grade malignant behavior and may ...
Lulu Feng, Lulu Feng, Lei Li, Lei Li, Yanmei He, Yanmei He, Wei Jiang, Wei Jiang   +7 more
doaj   +1 more source

Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity,

, 2002
Activation of tyrosine kinase receptors is associated with human tumors. Tumorigenic versions of several RTKs, such as Ret, Kit and Met carry activating mutations at highly conserved residues of the tyrosine kinase domain. We have investigated the effect
GRECO A., MIRANDA C, PAGLIARINI S, ZANOTTI, GIUSEPPE, PONZETTO C, PIEROTTI M. A   +5 more
core  

Homozygous mutations in NTRK1 gene underlie congenital insensitivity to pain with anhidrosis in Pakistani families

, 2016
Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive disorder presenting with loss of pain sensation, thermal sensation defects, and self-mutilating behavior.
Husna Zayadi
core   +1 more source