Results 51 to 60 of about 9,316 (206)

A Case of Infant-Type Hemispheric Glioma with NTRK1 Fusion

Child Neurology Open, 2022
The incidence of childhood central nervous system tumors in infants is about 6 per 100 000 children. Recent studies have showed recurrent fusion of the neurotrophic tyrosine receptor kinase (NTRK) gene in 10% of non-brainstem high grade glioma in very young children suggesting an oncogenic effect of the NTRK fusion genes.
Mekka R. Garcia, Lena Bell, Claire Miller, Devorah Segal   +3 more
openaire   +2 more sources

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

Clinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit, Maaike van Dartel, Laura Rodwell, Hanneke van der Woude, Cornelis Boersma, Peter G. M. Mol, Doranne Hilarius   +6 more
wiley   +1 more source

TRKA expression and NTRK1 gene copy number across solid tumours

, 2018
Aims Neurotrophic Tropomyosin Kinase Receptor 1 (NTRK1) gene encodes for the protein Tropomyosin-related kinase A (TRKA). Deregulated activity of TRKA has been shown to have oncogenic potential. We present here the results of an immunohistochemical (IHC)
Gianluca Mauri, Giulio Cerea, Patrizia Recchimuzzo, Maiolani, Martina, Rospo, Giuseppe, Silvio Veronese, Christiansen, Jason, Ivana Stella Cavenago, Emanuela Bonoldi, Michele Schirru, Alessio Amatu, Steven J Potts, Mauro Truini, Sartore-Bianchi, Andrea, Valentina Motta, Lauricella, Calogero, Bonoldi, Emanuela, Emanuele Valtorta, Giuseppe Rospo, Bonazzina, Erica Francesca, Marrapese, Giovanna, Giovanna Marrapese, Vincenzo Fiorillo, Martina Maiolani, Recchimuzzo, Patrizia, Motta, Valentina, Veronese, Silvio, Truini, Mauro, Mauri, Gianluca, Calogero Lauricella, Siena, Salvatore, Fiorillo, Vincenzo, Potts, Steven J, Cavenago, Ivana Stella, Salvatore Siena, Tosi, Federica, Federica Tosi, Jason Christiansen, Andrea Sartore-Bianchi, Valtorta, Emanuele, Erica Francesca Bonazzina, Schirru, Michele, Cerea, Giulio, Amatu, Alessio   +43 more
core   +1 more source

NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary [PDF]

, 2009
Recent studies have demonstrated that neurotrophins (NTs) and their NTRK tyrosine kinase receptors, thought to be exclusively required for the development of the nervous system, are also involved in controlling ovarian development.
García Rudaz, Cecilia, Paredes, Alfonso, Kerr, Bredford, Dorfman, Mauricio, Ojeda, Sergio R.   +4 more
core   +1 more source

NFASC-NTRK1 fusion.

, 2014
(A) Per-nucleotide read coverage (expression) of genomic regions along NFASC and NTRK1. The dotted line marks the DNA-level break-points in the two genes, as instructed by the fusion-point mapping result in panel B.
Hee-Jin Cho (539376), Do-Hyun Nam (184130), Jinkuk Kim (539374), Gye-Hyun Cho (539378), Kyeung Min Joo (184093), Young-Hyeh Ko (521737), Young-Eun Lee (296048), Jaeyeol An (539377), Yeri Lee (539375)   +8 more
core   +1 more source

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

The Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Masaru Yamashita   +3 more
wiley   +1 more source

Clinical, genomics and networking analyses of a high-altitude native American Ecuadorian patient with congenital insensitivity to pain with anhidrosis: a case report

BMC Medical Genomics, 2020
Background Congenital insensitivity to pain with anhidrosis (CIPA) is an extremely rare autosomal recessive disorder characterized by insensitivity to pain, inability to sweat and intellectual disability.
Andrés López-Cortés, Ana Karina Zambrano, Patricia Guevara-Ramírez, Byron Albuja Echeverría, Santiago Guerrero, Eliana Cabascango, Andy Pérez-Villa, Isaac Armendáriz-Castillo, Jennyfer M. García-Cárdenas, Verónica Yumiceba, Gabriela Pérez-M, Paola E. Leone, César Paz-y-Miño   +12 more
doaj   +1 more source

Identificación de genes de fusión NTRK. Experiencia en México

Gaceta Mexicana de Oncología, 2023
Objetivo: Evaluar la prevalencia de fusiones TRK en pacientes con cáncer en México. Material y métodos: En un estudio de tipo canasta, se determinó la presencia de genes de fusión NTRK, mediante inmunohistoquímica y secuenciación de nueva generación, en ...
Leticia Bornstein-Quevedo, Claudia Bautista-Wong, Zaira Mojica-González, Mario Gámez-Rosales, Katia Hop-García   +4 more
doaj   +1 more source

PDGFD‐Rearranged Dermatofibrosarcoma Protuberans With S100 and Pan‐TRK Expression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Dermatofibrosarcoma protuberans (DFSP) is a fibroblastic malignancy characterized in most cases by COL1A1::PDGFB fusion. Rare cases exhibit alternative rearrangements involving PDGFD. Here, we describe a female patient in her third decade of life who presented with a spindle cell proliferation on the shoulder.
Venezia Podesta, May P. Chan, Douglas Rottmann, Kelly L. Harms, Paul W. Harms   +4 more
wiley   +1 more source

Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion–Positive Tumor Cells in a Brain Metastasis Model

, 2018
Purpose: Rearrangement of the neurotrophic tropomyosin receptor kinase 1 (NTRK1) gene, which encodes tyrosine receptor kinase A (TRK-A), occurs in various cancers, including colon cancer.
Noritaka Furuya, Azusa Tanimoto, Rong Wang, Takayoshi Kinoshita, Sachiko Arai, Seiji Yano, Akihiro Nishiyama, Atsushi Tajima, Koji Fukuda, Kenji Kita, Shoichiro Tange, Tadaaki Yamada, Shinji Takeuchi   +12 more
core   +1 more source