Results 31 to 40 of about 9,316 (206)

Rearrangements of NTRK1 gene in papillary thyroid carcinoma [PDF]

Molecular and Cellular Endocrinology, 2010
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG.
A, Greco, C, Miranda, M A, Pierotti
openaire   +2 more sources

Seasonal Expression of NGF and Its Cognate Receptors in the Ovaries of Grey Squirrels (Sciurus carolinensis)

Animals, 2020
The grey squirrel is an invasive alien species that seriously threatens the conservation of the native red squirrel species. With the aim of characterizing the reproductive physiology of this species due to its great reproductive success, the function of
Margherita Maranesi, Francesco Alessandro Palermo, Antonello Bufalari, Francesca Mercati, Daniele Paoloni, Paolo Cocci, Giulia Moretti, Silvia Crotti, Massimo Zerani, Cecilia Dall’Aglio   +9 more
doaj   +1 more source

Ophthalmic findings of congenital insensitivity to pain with anhidrosis with a novel neurotrophic tyrosine kinase receptor type 1 gene mutation: A case report

Frontiers in Medicine, 2022
We report a case of congenital insensitivity to pain with anhidrosis (CIPA) with a novel neurotrophic tyrosine kinase receptor type 1 (NTRK1) gene mutation. The patient suffered from recurrent corneal ulcer.
Rong Zhu, Yuxiang Zhu, Mingpeng Xu, Zhensheng Gu   +3 more
doaj   +1 more source

Applicability of pan-TRK immunohistochemistry for identification of NTRK fusions in lung carcinoma

Scientific Reports, 2021
In the last two decades, various therapies have been introduced for lung carcinoma patients, including tyrosine-kinase inhibitors for different mutations. While some of them are specific to specific tumor types, others, like NTRK1–3 fusions, are found in
Simon Strohmeier, Iva Brcic, Helmut Popper, Bernadette Liegl-Atzwanger, Jörg Lindenmann, Luka Brcic   +5 more
doaj   +1 more source

A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis

BMC Medical Genetics, 2011
Background Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis.
Arístegui Javier, Garrote Elisa, Rodríguez Jose A, Sarasola Esther, García-Barcina Maria J   +4 more
doaj   +1 more source

NTRK fusion in Japanese colorectal adenocarcinomas

Scientific Reports, 2021
NTRK fusion-positive tumors are known to be highly sensitive to TRK inhibitors, such as larotrectinib and entrectinib. Therefore, identification of patients who can potentially benefit from these inhibitors is important; however, the frequency of NTRK ...
Yuya Yamashiro, Taisei Kurihara, Takuo Hayashi, Yoshiyuki Suehara, Takashi Yao, Shunsuke Kato, Tsuyoshi Saito   +6 more
doaj   +1 more source

Molecular consequences of NTRK1-fusion.

, 2014
(A) NTRK1 expression in 170 TCGA GBM samples (from 162 patients) with RNA-Seq data. Samples bearing NTRK1-fusion genes are marked and labeled. (B) Relationship between NTRK1 expression and NGF/TrkA-downstream pathway activity in 526 TCGA GBM samples ...
Hee-Jin Cho (539376), Do-Hyun Nam (184130), Jinkuk Kim (539374), Gye-Hyun Cho (539378), Kyeung Min Joo (184093), Young-Hyeh Ko (521737), Young-Eun Lee (296048), Jaeyeol An (539377), Yeri Lee (539375)   +8 more
core   +1 more source

Fusion-Negative NTRK Overexpression Exhibit Biological Relevance in Colorectal Cancer: Implications for Prediction of Responses to Kinase Inhibitors

Pharmaceuticals
Background/Objectives: The aims of this study are to define the roles of the neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2 and NTRK3 (NTRK1/2/3) in CRC and to determine the clinicopathological, molecular, cancer signalling and potential ...
Abdulaziz Alfahed
doaj   +1 more source

Case Report: Novel findings of larotrectinib in children with NTRK-rearranged spindle cell tumor

Frontiers in Oncology
Neurotrophic tropomyosin receptor kinase (NTRK)-rearranged spindle cell tumors are often resistant to chemotherapy and radiotherapy. Fortunately, they are sensitive to targeted therapy of tropomyosin receptor kinase (TRK) inhibitors. However, the data on
Linnan Wu, Linnan Wu, Weiji Xie, Weiji Xie, Juan Wang, Juan Wang, Suying Lu, Suying Lu, Yizhuo Zhang, Yizhuo Zhang, Junting Huang, Junting Huang   +11 more
doaj   +1 more source

Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells [PDF]

International Journal of Cancer, 2013
High levels of the NTRK1/TrkA receptor are expressed in low‐stage neuroblastomas, which are characterized by a good patient prognosis and often undergo spontaneous regression. In addition to apoptosis, tumor‐immune responses might contribute to this regression.
Pajtler, Kristian, Rebmann, Vera, Lindemann, Monika, Schulte, Johannes, Schulte, Stefanie, Stauder, Michael, Leuschner, Ivo, Schmid, Kurt Werner, Köhl, Ulrike, Schramm, Alexander, Eggert, Angelika   +10 more
openaire   +3 more sources