Results 11 to 20 of about 9,316 (206)

NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

Cell Death Discovery, 2023
Hippocampal neuronal damage may induce cognitive impairment. Neurotrophic tyrosine kinase receptor 1 (NTRK1) reportedly regulates neuronal damage, although the underlying mechanism remains unclear. The present study aimed to investigate the role of NTRK1
Kai Yang, Jue Wu, Shang Li, Shan Wang, Jing Zhang, Yi-peng Wang, You-sheng Yan, Hua-ying Hu, Ming-fang Xiong, Chao-bo Bai, Yong-qing Sun, Wen-qi Chen, Yang Zeng, Jun-liang Yuan, Cheng-hong Yin   +14 more
doaj   +2 more sources

Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer

Translational Oncology, 2018
NTRK1 gene fusions, the targets of multikinase inhibitors, are promising therapeutic targets for colorectal cancer (CRC). However, screening methods for detecting NTRK1 gene fusions in CRC tissues have not been reported.
Yuri Choi, Yeo-Jin Won, Sojeong Lee, Ahrong Kim, Younggeum Kim, Won-Young Park, Hong-Jae Jo, Geun Am Song, Chae Hwa Kwon, Do Youn Park   +9 more
doaj   +2 more sources

Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain

Biomedicines
Background: Chronic postsurgical pain (CPSP) poses a major clinical challenge due to unresolved links between neurotrophic pathways and endoplasmic reticulum (ER) stress.
Caixia Zhang, Kaiwen Zhang, Wencui Zhang, Bo Jiao, Xueqin Cao, Shangchen Yu, Mi Zhang, Xianwei Zhang   +7 more
doaj   +2 more sources

Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain

Scientific Reports
Ntrk1 (also known as TrkA) is a nerve growth factor receptor with essential roles in the development and function of the cholinergic nervous system. Ntrk1 is expressed in a few specific and defined brain areas.
Kazuo Nakajima, Mizuho Ishiwata, Tadafumi Kato   +2 more
doaj   +2 more sources

Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice [PDF]

Translational Psychiatry, 2020
Previously, we reported a family in which bipolar disorder (BD) co-segregates with a Mendelian kidney disorder linked to 1q22. The causative renal gene was later identified as MUC1.
Kazuo Nakajima, Alannah Miranda, David W. Craig, Tatyana Shekhtman, Stanislav Kmoch, Anthony Bleyer, Szabolcs Szelinger, Tadafumi Kato, John R. Kelsoe   +8 more
doaj   +2 more sources

TMP3-NTRK1 rearranged uterine sarcoma: A case report

Case Reports in Women's Health, 2020
Uterine sarcomas are a group of rare tumours with heterogeneous morphological and genetic features. Recent advances in the molecular characterisation of these tumours have identified a novel clinicopathological category underpinned by NTRK gene fusions.We present the case of a 42-year-old woman with a polypoid cervical lesion formed of densely cellular,
William Boyle, Anthony Williams, Sudha Sundar, Jason Yap, Philippe Taniere, Pauline Rehal, Raji Ganesan   +6 more
openaire   +4 more sources

A Novel Oncogenic and Drug-Sensitive KIF5B-NTRK1 Fusion in Lung Adenocarcinoma

Current Oncology
We present a case of a lung adenocarcinoma patient harboring a novel kinesin family member 5B (KIF5B)-NTRK1 gene fusion that responds well to entrectinib.
Hui Li, Huicong Liu, Lisha Xiao, Huabin Gao, Huiting Wei, Anjia Han, Gengpeng Lin   +6 more
doaj   +2 more sources

Ameloblastic Fibrosarcoma of the Jaw: Case Report, Genetic Profiling, and Literature Review

Case Reports in Oncology, 2023
Ameloblastic fibrosarcoma (AFS) is considered a malignant progression resulting from dysplastic changes in an ameloblastic fibroma (AF). Both tumors are extremely rare, with only a few cases reported in the scientific literature.
Duna Barakeh, Afaf Alsolami, Malak Abedalthagafi   +2 more
doaj   +1 more source

The discovery of hidden guanylate cyclases (GCs) in the Homo sapiens proteome

Computational and Structural Biotechnology Journal, 2023
Recent discoveries have established functional guanylate cyclase (GC) catalytic centers with low activity within kinase domains in plants. These crypto GCs generate guanosine 3’,5’-cyclic monophosphate (cGMP) essential for both intramolecular and ...
Ilona Turek, Lubna Freihat, Jignesh Vyas, Janet Wheeler, Victor Muleya, David T. Manallack, Chris Gehring, Helen Irving   +7 more
doaj   +1 more source

Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer

, 2014
We have identified a ligand-independent mechanism whereby the tumor suppressor, TP53, induces nerve growth factor receptor, NTRK1, phosphorylation at Y674/Y675 (NTRK1-pY674/pY675), via the repression of the NTRK1-phosphatase, PTPN6.
Agbaje, O., Agbaje, Orunsola, Montano Hernandez, X., Crompton, T., Youssef, G., Gillett, C., Youssef, Gehad, Gillett, Cheryl, Montano, Ximena, Crompton, Tessa   +9 more
core   +6 more sources