Results 21 to 30 of about 9,316 (206)

Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways

BMC Nephrology, 2022
Background Mesangial proliferative glomerulonephritis (MsPGN) accounts for a main cause of chronic kidney disease (CKD), chronic renal failure and uremia.
Xiongjun Dong, Yingchun Tang
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Identification of NTRK gene fusions in lung adenocarcinomas in the Chinese population

The Journal of Pathology: Clinical Research, 2021
The molecular profile of neurotrophic tyrosine kinase receptor (NTRK) gene fusions in lung adenocarcinoma (LUAD) is not fully understood. Next‐generation sequencing (NGS) and pan‐tyrosine kinase receptor (TRK) immunohistochemistry (IHC) are powerful ...
Ruiying Zhao, Feng Yao, Chan Xiang, Jikai Zhao, Zhanxian Shang, Lianying Guo, Wenjie Ding, Shengji Ma, Anbo Yu, Jinchen Shao, Lei Zhu, Yuchen Han   +11 more
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Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors

Diagnostic Pathology, 2020
Background While ETV6- NTRK3 fusion is common in infantile fibrosarcoma, NTRK1/3 fusion in pediatric tumors is scarce and, consequently, not well known.
Jeongwan Kang, Jin Woo Park, Jae-Kyung Won, Jeong Mo Bae, Jaemoon Koh, Jeemin Yim, Hongseok Yun, Seung-Ki Kim, Jung Yoon Choi, Hyoung Jin Kang, Woo Sun Kim, Joo Heon Shin, Sung-Hye Park   +12 more
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Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults [PDF]

, 2012
Free to read\ud \ud The NTRK1 gene (also known as TRKA) encodes a high-affinity receptor for NGF, a neurotrophin involved in nervous system development and myelination.
Jahanshad, Neda, McMahon, Katie L., Johnson, Kori, Wright, Margaret J., Braskie, Meredith N., Stein, Jason L., de Zubicaray, Greig I., Barysheva, Marina, Ringman, John M., Martin, Nicholas G., Thompson, Paul M., Toga, Arthur W.   +11 more
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Novel Gross Deletion Mutations in NTRK1 Gene Associated With Congenital Insensitivity to Pain With Anhidrosis

Frontiers in Pediatrics, 2021
Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare inherited autosomal recessive disorder characterized by insensitivity to noxious stimuli, anhidrosis, recurrent fever, and intellectual disability.
Lulu Li, Chao Jia, Yue Tang, Yuanyuan Kong, Yaofang Xia, Li Ma   +5 more
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Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis

Molecular Genetics & Genomic Medicine, 2021
Background Congenital insensitivity to pain (CIP) conditions are a group of Mendelian disorders with clinical and genetic heterogeneity. CIP with anhidrosis (CIPA) is a distinct subtype caused by biallelic variants in the NTRK1 gene.
Shang Li, Hua‐ying Hu, Jun‐Jun Xu, Zhan‐ke Feng, Yong‐qing Sun, Xu Chen, Kai Yang, Ya‐zhou Li, Dong‐liang Zhang   +8 more
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Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

Cell Reports, 2020
Summary: NTRK1 gene fusions are actionable drivers of numerous human malignancies. Here, we show that expression of the TPR-NTRK1 fusion kinase in immortalized mouse pancreatic ductal epithelial (IMPE) (pancreas) or mouse lung epithelial (MLE-12) cells ...
Aria Vaishnavi, Michael T. Scherzer, Conan G. Kinsey, Gennie L. Parkman, Amanda Truong, Phaedra Ghazi, Sophia Schuman, Benjamin Battistone, Ignacio Garrido-Laguna, Martin McMahon   +9 more
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NTRK1 is a positive regulator of YAP oncogenic function [PDF]

Oncogene, 2018
Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP). Nevertheless, how YAP is controlled by pathway crosstalks in tumourigenesis remains poorly understood.
Xinyuan, Yang, He, Shen, Brian, Buckley, Yanmin, Chen, Nuo, Yang, Ashley L, Mussell, Mikhail, Chernov, Lester, Kobzik, Costa, Frangou, Su-Xia, Han, Jianmin, Zhang   +10 more
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Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis. [PDF]

PLoS ONE, 2013
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare inherited disorder of the peripheral nervous system resulting from mutations in neurotrophic tyrosine kinase receptor 1 gene (NTRK1), which encodes the high-affinity nerve growth factor ...
Li Gao, Hao Guo, Nan Ye, Yudi Bai, Xin Liu, Ping Yu, Yang Xue, Shufang Ma, Kewen Wei, Yan Jin, Lingying Wen, Kun Xuan   +11 more
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Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy

Oncogenesis, 2023
The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as pan-tumor oncogenic drivers has led to new personalized therapies in oncology.
Fabio Vanoli, Laurie Herviou, Yusuke Tsuda, Patricia Sung, Ziyu Xie, Eve Fishinevich, Soe S. Min, William Mallen, Henry de Traux de Wardin, Yanming Zhang, Maria Jasin, Cristina R. Antonescu   +11 more
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