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High-grade glioneuronal tumor with an ARHGEF2–NTRK1 fusion gene
Brain Tumor Pathology, 2019Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected two cystic lesions bilaterally in the frontal areas with surrounding edema. The left larger tumor was removed by left frontal craniotomy.
Kazuhiko Kurozumi +12 more
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An NTRK1-associated Genes Classification Predicts Prognosis in Pediatric Sarcoma Cases
2023Introduction: NTRK-rearranged spindle cell neoplasm is an emerging tumor entity. The genetic mechanisms and prognostic implications of this entity are mainly unknown. The corresponding targeting therapy strategies have been widely developed. Method: In this study, we summarized the immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH)
Lianyuan Yu, Lejian HE
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Cloning and functional analysis of the root‐knot nematode resistance gene
AbstractTobacco (Nicotiana tabacum L.) is an economically important crop worldwide. Root‐knot nematodes (RKNs) are responsible for yield losses in tobacco and other crops, such as tomato, potato, peanut, and soybean. Therefore, screening for resistance genes that can prevent RKN infestation and the associated damage is crucial.
Luyang Zhang +6 more
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Genomic organization of the human NTRK1 gene.
Oncogene, 1997The NTRK1 gene encodes one of the receptors for the Nerve Growth Factors and it is located at 1q21-22. Rearrangements of NTRK1 are frequently detected in human papillary thyroid carcinoma and lead to the formation of chimeric oncogenes, similarly to what observed for the other neurotrophin receptor RET. In addition, the two receptor genes are target of
A, Greco, R, Villa, M A, Pierotti
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Česká gynekologie
Objective: To investigate DNA methylation of specific tumor suppressor genes in endometrial hyperplasia compared to normal endometrial tissue. File and methodology: To search for epigenetic events, methylation-specific multiplex ligation-dependent probe amplification was employed to compare the methylation status of 40 tissue samples with atypical ...
Ondřej, Dvořák +5 more
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Objective: To investigate DNA methylation of specific tumor suppressor genes in endometrial hyperplasia compared to normal endometrial tissue. File and methodology: To search for epigenetic events, methylation-specific multiplex ligation-dependent probe amplification was employed to compare the methylation status of 40 tissue samples with atypical ...
Ondřej, Dvořák +5 more
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
exaly