Results 31 to 40 of about 6,777,214 (229)
Frontiers in Medicine, 2022 We report a case of congenital insensitivity to pain with anhidrosis (CIPA) with a novel neurotrophic tyrosine kinase receptor type 1 (NTRK1) gene mutation. The patient suffered from recurrent corneal ulcer.
Rong Zhu +3 more
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Rearrangements of NTRK1 gene in papillary thyroid carcinoma [PDF]
Molecular and Cellular Endocrinology, 2010 TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG.
A, Greco, C, Miranda, M A, Pierotti
openaire +2 more sources
BMC Nephrology, 2022 Background Mesangial proliferative glomerulonephritis (MsPGN) accounts for a main cause of chronic kidney disease (CKD), chronic renal failure and uremia.
Xiongjun Dong, Yingchun Tang
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A Rare Case of Recurrent Ovarian Cancer With NTRK1-TPM3 Gene Rearrangement [PDF]
, 2021 Abstract Background: NTRK gene fusion is rare in gynecologic cancer. Entrectinib is a novel targeted drug which is a potent inhibitor of TRK A, B and C. Here, we present a case of recurrent ovarian cancer with NTRK1-TPM3 rearrangement, which was detected by next-generation sequencing (NGS) and treated with entrectinib.
Yuta Endo +14 more
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Identification of NTRK gene fusions in lung adenocarcinomas in the Chinese population
The Journal of Pathology: Clinical Research, 2021 The molecular profile of neurotrophic tyrosine kinase receptor (NTRK) gene fusions in lung adenocarcinoma (LUAD) is not fully understood. Next‐generation sequencing (NGS) and pan‐tyrosine kinase receptor (TRK) immunohistochemistry (IHC) are powerful ...
Ruiying Zhao +11 more
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Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer
Translational Oncology, 2018 NTRK1 gene fusions, the targets of multikinase inhibitors, are promising therapeutic targets for colorectal cancer (CRC). However, screening methods for detecting NTRK1 gene fusions in CRC tissues have not been reported.
Yuri Choi +9 more
doaj +1 more source
Animals, 2020 The grey squirrel is an invasive alien species that seriously threatens the conservation of the native red squirrel species. With the aim of characterizing the reproductive physiology of this species due to its great reproductive success, the function of
Margherita Maranesi +9 more
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NTRK1 fusion in glioblastoma multiforme. [PDF]
PLoS ONE, 2014 Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy with substantial survival benefit. Recent studies on solid tumors showed that fusion genes often play driver roles and are promising targets for ...
Jinkuk Kim +8 more
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Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis [PDF]
, 2016 Dedifferentiated chondrosarcoma (DDCS) is a rare disease with a dismal prognosis. DDCS consists of two morphologically distinct components: the cartilaginous and noncartilaginous components.
Cao, Dengfeng +13 more
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Cell Reports, 2020 Summary: NTRK1 gene fusions are actionable drivers of numerous human malignancies. Here, we show that expression of the TPR-NTRK1 fusion kinase in immortalized mouse pancreatic ductal epithelial (IMPE) (pancreas) or mouse lung epithelial (MLE-12) cells ...
Aria Vaishnavi +9 more
doaj +1 more source