Results 31 to 40 of about 2,522,601 (164)

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer [PDF]

, 2015
IntroductionChromosomal rearrangements involving neurotrophic tyrosine kinase 1 (NTRK1) occur in a subset of non-small cell lung cancers (NSCLCs) and other solid tumor malignancies, leading to expression of an oncogenic TrkA fusion protein.
Lim, Jonathan E, Iafrate, Anthony J, Chow-Maneval, Edna, Shaw, Alice T, Patel, Manish, Iafrate, Anthony J., Le, Long P, Costa, Daniel B., Costa, Daniel B, Hornby, Zachary, Lim, Jonathan E., Jackman, David, Muzikansky, Alona, Li, Gary G., Farago, Anna F, Zheng, Zongli, Ou, Sai-Hong I, Liu, Stephen V., Luo, David, Drilon, Alexander, Ou, Sai-Hong I., Bauer, Todd M., Multani, Pratik S, Bauer, Todd M, Shaw, Alice T., Liu, Stephen V, Li, Gary G, Farago, Anna F., Le, Long P., Multani, Pratik S.   +29 more
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Fusion-Negative NTRK Overexpression Exhibit Biological Relevance in Colorectal Cancer: Implications for Prediction of Responses to Kinase Inhibitors

Pharmaceuticals
Background/Objectives: The aims of this study are to define the roles of the neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2 and NTRK3 (NTRK1/2/3) in CRC and to determine the clinicopathological, molecular, cancer signalling and potential ...
Abdulaziz Alfahed
doaj   +1 more source

The Genomic and Proteomic Profiles of NTRK Genes and Trk Receptors in Liver Hepatocellular Carcinoma

Clinical Medicine Insights: Oncology, 2023
Background: The neurotrophic tyrosine kinase (NTRK) gene family includes NTRK1, NTRK2, and NTRK3, which encode tropomyosin receptor kinases TrkA, TrkB, and TrkC, respectively.
Hejing Wang, Lina Qi, Chenhan Zhong, Xuefeng Fang, Ying Yuan   +4 more
doaj   +1 more source

TRKA expression and NTRK1 gene copy number across solid tumours

, 2018
Aims Neurotrophic Tropomyosin Kinase Receptor 1 (NTRK1) gene encodes for the protein Tropomyosin-related kinase A (TRKA). Deregulated activity of TRKA has been shown to have oncogenic potential. We present here the results of an immunohistochemical (IHC)
Gianluca Mauri, Giulio Cerea, Patrizia Recchimuzzo, Maiolani, Martina, Rospo, Giuseppe, Silvio Veronese, Christiansen, Jason, Ivana Stella Cavenago, Emanuela Bonoldi, Michele Schirru, Alessio Amatu, Steven J Potts, Mauro Truini, Sartore-Bianchi, Andrea, Valentina Motta, Lauricella, Calogero, Bonoldi, Emanuela, Emanuele Valtorta, Giuseppe Rospo, Bonazzina, Erica Francesca, Marrapese, Giovanna, Giovanna Marrapese, Vincenzo Fiorillo, Martina Maiolani, Recchimuzzo, Patrizia, Motta, Valentina, Veronese, Silvio, Truini, Mauro, Mauri, Gianluca, Calogero Lauricella, Siena, Salvatore, Fiorillo, Vincenzo, Potts, Steven J, Cavenago, Ivana Stella, Salvatore Siena, Tosi, Federica, Federica Tosi, Jason Christiansen, Andrea Sartore-Bianchi, Valtorta, Emanuele, Erica Francesca Bonazzina, Schirru, Michele, Cerea, Giulio, Amatu, Alessio   +43 more
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NTRK1/TrkA Activation Overrides the G2/M-Checkpoint upon Irradiation

, 2021
High expression of the receptor tyrosine kinase TrkA/NTRK1 is associated with a favorable outcome in several solid tumors of childhood including neuroblastoma.
Vivian Boron, Sebastian Oeck, Alexander Schramm, Ines Rudolf, George Iliakis, Aashish Soni, Christina Hassiepen   +6 more
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A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis

, 2019
Congenital insensitivity to pain with anhidrosis (CIPA) is a very rare autosomal recessive disease characterized by pain insensitivity, frequent intermittent fevers, anhidrosis, self-mutilating actions and mental retardation.
Sobhani, Maryam, Ghafouri-Fard, Soudeh, Yazarlou, Fatemeh, Hajiesmaeil, Mogge   +3 more
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Unclassified mesenchymal sarcoma with NTRK1-KHDRBS1 gene fusion: a case report of long-term tumor-free survival with crizotinib treatment

World Journal of Surgical Oncology, 2021
Background Mesenchymal sarcomas are tumors that originate from mesenchymal tissue. Most mesenchymal sarcomas can be accurately classified, but some are unclassifiable in clinical practice.
Weijie Chen, Huimei Wang, Dongxian Jiang, Lijuan Luan, Yuhong Zhou, Yingyong Hou   +5 more
doaj   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre, J Worthington, X Ke, P Martin, W Thomson, A Hinks, E Flynn, J Packham, A Barton, Martin, P., Barton, A., Gardner-Medwin, J. [CAPS and BSPAR study groups], UKRAG Consortium, Worthington, J., Thomson, W., Flynn, E., Packham, J., Hinks, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Eyre, S., Ke, X., Childhood Arthritis Prospective Study (CAPS)   +21 more
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Molecular consequences of NTRK1-fusion.

, 2014
(A) NTRK1 expression in 170 TCGA GBM samples (from 162 patients) with RNA-Seq data. Samples bearing NTRK1-fusion genes are marked and labeled. (B) Relationship between NTRK1 expression and NGF/TrkA-downstream pathway activity in 526 TCGA GBM samples ...
Hee-Jin Cho (539376), Do-Hyun Nam (184130), Jinkuk Kim (539374), Gye-Hyun Cho (539378), Kyeung Min Joo (184093), Young-Hyeh Ko (521737), Young-Eun Lee (296048), Jaeyeol An (539377), Yeri Lee (539375)   +8 more
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Phenotypic heterogeneity of intellectual disability in patients with congenital insensitivity to pain with anhidrosis: A case report and literature review

Journal of International Medical Research, 2018
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive heterogeneous disorder mainly caused by mutations in the neurotrophic tyrosine receptor kinase 1 gene ( NTRK1 ) and characterized by insensitivity to noxious stimuli ...
Zhenlei Liu, Jiaqi Liu, Gang Liu, Wenjian Cao, Sen Liu, Yixin Chen, Yuzhi Zuo, Weisheng Chen, Jun Chen, Yu Zhang, Shishu Huang, Guixing Qiu, Philip F. Giampietro, Feng Zhang, Zhihong Wu, Nan Wu   +15 more
doaj   +1 more source