Results 101 to 110 of about 910,008 (206)

Recurrent SPECC1L–NTRK fusions in pediatric sarcoma and brain tumors [PDF]

Molecular Case Studies, 2020
The identification of rearrangements driving expression of neurotrophic receptor tyrosine kinase (NTRK) family kinases in tumors has become critically important because of the availability of effective, specific inhibitor drugs. Whole-genome sequencing (WGS) combined with RNA sequencing (RNA-seq) can identify novel and recurrent expressed fusions. Here
Khuong-Quang, DA, Brown, LM, Wong, M, Mayoh, C, Sexton-Oates, A, Kumar, A, Pinese, M, Nagabushan, S, Lau, L, Ludlow, LE, Gifford, AJ, Rodriguez, M, Desai, J, Fox, SB, Haber, M, Ziegler, DS, Hansford, JR, Marshall, GM, Cowley, MJ, Ekert, PG, Wong-Erasmus, Marie   +20 more
openaire   +3 more sources

Phase 1 dose escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer-Lack of association between activating AKT mutation and AKT inhibition-derived efficacy [PDF]

, 2019
This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced ...
Boix, Oliver, Hess, Dagmar, Hurvitz, Sara A, Joerger, Markus, Lagkadinou, Eleni, Ma, Cynthia, Moulder, Stacy, Ocker, Matthias, Rentzsch, Christine, Rudolph, Marion, Schneeweiss, Andreas, Thiele, Silke, Tsimberidou, Apostolia M, Varga, Andrea, Wilkinson, Gary   +14 more
core   +3 more sources

Precision medicine in cutaneous melanoma—A comprehensive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley   +1 more source

R-parity violating supersymmetry and neutrino physics: experimental signatures

, 2015
$R$-parity violating supersymmetric models (RPV SUSY) are becoming increasingly more appealing than its $R$-parity conserving counterpart in view of the hitherto non-observation of SUSY signals at the LHC.
Mitsou, Vasiliki A.
core   +1 more source

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]

, 2010
Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P., Brockington, A., Carmeliet, P., Claes, F., Heath, P.R., Holden, H., Kasher, P., Lambrechts, D., Sendtner, M., Shaw, P.J.   +9 more
core   +4 more sources

The spectrum of breast in situ papillary carcinomas with invasion and invasive breast carcinomas with papillary features: an overview of histological subtypes and diagnostic challenges

Histopathology, Volume 88, Issue 4, Page 747-768, March 2026.
Invasive breast carcinomas with papillary features (IBCP) comprise diverse subtypes with variable architecture, histopathology, and clinical behaviour. This review outlines evolving classification, diagnostic criteria, and treatment implications, highlighting challenges in distinguishing in situ from invasive lesions. Standardised diagnostic approaches
Emad A Rakha, Puay Hoon Tan, Wendy A Raymond   +2 more
wiley   +1 more source

Gluon saturation and initial conditions for relativistic heavy ion collisions

, 2014
We present an overview of theoretical aspects of the phenomenon of gluon saturation in high energy scattering in Quantum Chromo Dynamics. Then we review the state-of-the-art of saturation-based phenomenological approaches to the study and ...
Albacete, Javier L., Marquet, Cyrille
core   +1 more source

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age [PDF]

, 2015
Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients.
Amon, Baker, Barnholtz-Sloan, Barnholtz-Sloan, Chun, Chun, Chun, Cleveland, Collins, Collins, Collins, Compton, Cotman, Coyle, Cui, Di Agostino, Eischen, Eischen, Fletcher, Gandolfi, Gray, Gronych, Grundy, Guadagno, Guadagno, Gutmann, Gutmann, Hasselblatt, Hawkins, Hoffmann, Hoffmann, Hoffmann, Hoffmann, Huether, Jones, Kleihues, Kruchko, Lee, Levine, Li, Liu, Lozano, Lozano, Manfredi, Montagna, Montagna, Paulus, Pekrun, Pellman, Pfister, Prados, Puduvalli, Reifenberger, Rhee, Van den Berghe, Zlotnik   +55 more
core   +5 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Genomic Features of Solid Tumor Patients Harboring ALK/ROS1/NTRK Gene Fusions

Frontiers in Oncology, 2022
The fusions of receptor tyrosine kinase (RTK) involving anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and neurotrophic receptor tyrosine kinase (NTRK) represent the potential targets of therapeutic intervention for various types of solid ...
Yinghuan Dai, Ping Liu, Wenlong He, Lizhen Yang, Yang Ni, Yang Ni, Xuejiao Ma, Xuejiao Ma, Furong Du, Furong Du, Chao Song, Chao Song, Yang Liu, Yi Sun   +13 more
doaj   +1 more source