Results 61 to 70 of about 910,008 (206)
Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features [PDF]
, 2018 Diffuse leptomeningeal glioneuronal tumors (DLGNT) represent rare CNS neoplasms which have been included in the 2016 update of the WHO classification. The wide spectrum of histopathological and radiological features can make this enigmatic tumor entity ...
Brandner, Sebastian +34 more
core +1 more source
Scientific Reports, 2023 NTRK1, 2, and 3 fusions are important therapeutic targets for NSCLC patients, but their prevalence in South American admixed populations needs to be better explored.
Rodrigo de Oliveira Cavagna +18 more
doaj +1 more source
Molecular characterization of cancers with NTRK gene fusions [PDF]
Modern Pathology, 2019 Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently detected in rare cancer types (e.g., secretory breast carcinoma and congenital infantile fibrosarcoma), but the occurrence of NTRK fusions in common cancers and their ...
Zoran Gatalica +3 more
openaire +4 more sources
Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Adults
Current Oncology, 2021 The tyrosine receptor kinase (TRK) inhibitors larotrectinib and entrectinib were recently approved in Canada for the treatment of solid tumours harbouring neurotrophic tyrosine receptor kinase (NTRK) gene fusions.
D. Gwyn Bebb +17 more
doaj +1 more source
Search for a very light NMSSM Higgs boson produced in decays of the 125 GeV scalar boson and decaying into t leptons in pp collisions at vs=8 TeV [PDF]
, 2016 Khachatryan, V., Sirunyan, A.M., Tumasyan, A., Adam, W., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Erö, J., Flechl, M., Friedl, M., Frühwirth, R., Ghete, V.M., Hartl, C., Hörmann, N., Hrubec, J., Jeitler, M., Knünz, V ...
CMS Collaboration +9 more
core +1 more source
Frontiers in Oncology, 2023 Pancreatic neuroendocrine carcinoma (panNEC) is a rare disease. The rearrangements of neurotrophic tropomyosin receptor kinase (NTRK) genes are oncogenic.
Wen-Chi Wu +6 more
doaj +1 more source
BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer [PDF]
, 2009 Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, RET and neurotrophic tyrosine kinase receptor type I (NTRK1)
Baumgartner, Adolf +6 more
core +2 more sources
Cancers, 2021 Simple Summary NTRK fusion genes are important but not well studied molecular markers in thyroid cancer. Their identification could help improve diagnosis and prognosis, and determine appropriate treatment.
Barbora Pekova +16 more
semanticscholar +1 more source
Phase separation underlies signaling activation of oncogenic NTRK fusions
Proceedings of the National Academy of Sciences, 2023 NTRK (neurotrophic tyrosine receptor kinase) gene fusions that encode chimeric proteins exhibiting constitutive activity of tropomyosin receptor kinases (TRK), are oncogenic drivers in multiple cancer types. However, the underlying mechanisms in oncogenesis that involve various N-terminal fusion partners of NTRK fusions remain ...
Tianxin Zhu +10 more
openaire +2 more sources
Therapeutic Advances in Medical Oncology, 2020 Introduction: The research objective was to systematically review evidence on neurotrophic tyrosine receptor kinase ( NTRK ) gene fusion frequency in solid tumors. Methods: Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
Anna Forsythe +5 more
doaj +1 more source