Results 11 to 20 of about 137,304 (192)

Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal-Weight Rats, Prevented by Perinatal Leptin Intake. [PDF]

Mol Nutr Food Res
Early‐life exposure of rats to high‐fat‐isocaloric diet leads to metabolically obese, normal‐weight phenotype, and impaired cognition. Hippocampal transcriptomic analysis reveals disruption in pathways linked to obesity and cognitive decline, which is mitigated by perinatal leptin supplementation. PBMC share common altered genes with hippocampus, which
García-Ruano C, Costa A, Palou A, Oliver P.   +3 more
europepmc   +2 more sources

Sex-Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo-Inositol Supplementation During Suckling. [PDF]

Mol Nutr Food Res
This graphical abstract illustrates the effects of myo‐inositol supplementation during suckling in reducing long‐term metabolic impacts from mild gestational calorie restriction (GCR). Using a metabolomics approach, 164 metabolites were identified, with greater metabolic alterations in males.
Martín-Chamorro RA, Martin JC, Castillo P, Palou M, Palou A, Rodríguez AM, Picó C.   +6 more
europepmc   +2 more sources

Impact of Western diet on milk miRNAs and target genes in offspring adipose tissue: modulation by betaine during suckling. [PDF]

Obesity (Silver Spring)
Abstract Objective We investigated how a maternal Western diet (WD) affects milk microRNA (miRNA) profile and associates with metabolic programming in adipose tissues in pups. We also explored the impact of betaine supplementation during suckling, as betaine levels are reported to be reduced in WD‐fed dams' milk.
Martín-Chamorro RA, Pomar CA, Palou A, Picó C, Rodríguez AM.   +4 more
europepmc   +2 more sources

Biofilm in Diabetic Foot Ulcers: A Systematic Narrative Review. [PDF]

Int Wound J
ABSTRACT Biofilms are a key driver of chronicity and treatment failure in diabetic foot ulcers (DFUs), yet clinical evidence quantifying their impact and management remains fragmented. This systematic narrative review synthesised recent evidence (2015–2025) on the prevalence, diagnostics, and management of biofilm in DFUs.
Theodorakopoulos G, Armstrong DG.
europepmc   +2 more sources

“Highly nuanced policy is very difficult to apply at scale”: Examining researcher account and content takedowns online

Policy &Internet, Volume 15, Issue 4, Page 559-574, December 2023., 2023
Abstract Since 2019, researchers examining, archiving, and collecting extremist and terrorist materials online have increasingly been taken offline. In part a consequence of the automation of content moderation by different technology companies and national governments calling for ever quicker takedowns. Based on an online survey of peers in the field,
Aaron Y. Zelin
wiley   +1 more source

Port Authority of Cartagena: Evidence of a Sustainability Balanced Scorecard

Sustainable Development, Volume 31, Issue 5, Page 3761-3785, October 2023., 2023
Abstract This paper provides a deeper understanding to the development and implementation of a Sustainability Balanced Scorecard in the Port Authority of Cartagena, under exploratory research. Open‐access documents available on different websites were used as data sources combined with semi‐structured personal interviews, which took place at the ...
Carlos Suárez‐Gargallo, Patrocinio Zaragoza‐Sáez   +1 more
wiley   +1 more source

Stachydrine, N‐acetylornithine and trimethylamine N‐oxide levels as candidate milk biomarkers of maternal consumption of an obesogenic diet during lactation

BioFactors, Volume 49, Issue 5, Page 1022-1037, September/October 2023., 2023
Reverting to a healthy maternal diet during lactation normalizes the altered milk metabolome found in obese rats. Stachydrine, N‐acetylornithine and TMAO levels are proposed as candidate biomarkers of maternal consumption of an obesogenic diet during lactation.
Pedro Castillo, Ondrej Kuda, Jan Kopecky, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Picó   +6 more
wiley   +1 more source

An elevational gradient in floral traits and pollinator assemblages in the Neotropical species Costus guanaiensis var. tarmicus in Peru

Ecology and Evolution, Volume 13, Issue 8, August 2023., 2023
We analyzed floral traits and pollinator assemblages in the Neotropical species Costus guanaiensis var. tarmicus along a steep elevational gradient in Peru. Results show floral traits and pollinator assemblage variation along the elevational gradient. We examined our results considering two hypotheses: (1) local adaptation to different bee assemblages ...
Rossana Maguiña‐Conde, Dorali Zuñiga‐Rivas, Kathleen M. Kay   +2 more
wiley   +1 more source

Timing of minor and major amputation in patients with diabetes‐related foot ulceration admitted to two public tertiary referral hospitals in Australia

ANZ Journal of Surgery, Volume 93, Issue 6, Page 1510-1516, June 2023., 2023
For inpatients with diabetes‐related foot ulceration (DFU) the incidence of minor amputation was 34% and major amputation was 8% over four years. Most amputations occurred during the patient's index DFU‐related hospital admission. Minor amputation during the patient's index DFU‐related admission was associated with requiring revascularisation, while ...
Sarah M. Manewell, Sarah J. Aitken, Vanessa L. Nube, Anna M. Crawford, Maria I. Constantino, Stephen M. Twigg, Hylton B. Menz, Catherine Sherrington, Serene S. Paul   +8 more
wiley   +1 more source

Physical intradialytic patient‐reported outcome measures in haemodialysis and haemodiafiltration: A cross‐over study

Nephrology, Volume 28, Issue 5, Page 261-271, May 2023., 2023
Abstract Aim Standard haemodialysis (sHD) is associated with a poor survival and marked adverse intradialytic patient‐reported outcome measures (ID‐PROMs). Whereas physical ID‐PROMs (PID‐PROMs) are alleviated by cool dialysate (cHD), survival is prolonged by haemodiafiltration (HDF).
Gertrude Wijngaarden, Paul A. Rootjes, Menso J. Nubé, Camiel L. M. de Roij van Zuijdewijn, Muriel P. C. Grooteman   +4 more
wiley   +1 more source