Results 111 to 120 of about 31,361 (244)

The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding

Scientific Reports, 2017
The herpes simplex virus (HSV) UL31 gene encodes a conserved member of the herpesvirus nuclear egress complex that not only functions in the egress of DNA containing capsids from the nucleus, but is also required for optimal replication of viral DNA and ...
Maxwell R. Sherry, Thomas J. M. Hay, Michael A. Gulak, Arash Nassiri, Renée L. Finnen, Bruce W. Banfield   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

PLoS Pathogens, 2018
Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure specific nuclear import of viral and host components. While some import cargoes bind directly to certain transport factors, most
Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik   +17 more
doaj   +1 more source

HVint: a strategy for identifying novel protein-protein interactions in Herpes Simplex Virus Type 1 [PDF]

, 2016
Human herpesviruses are widespread human pathogens with a remarkable impact on worldwide public health. Despite intense decades of research, the molecular details in many aspects of their function remain to be fully characterized.
Albright, Antinone, Aranda, Bastian, Berman, Blohm, Booy, Brady, Brückner, Budayeva, Calderone, Calderwood, Cardone, Chabaud, Chabaud, Chatr-Aryamontri, Chen, Chen, Chentoufi, Chowdary, Coller, Conner, Connolly, Cristea, Dai, Dai, Daikoku, de Chassey, de Oliveira, DeBlasio, Deng, Desai, Desai, Desai, Deutsch, Douglas, Dufour, Durmuş Tekir, Döhner, Eisenberg, Engel, Folador, Fossum, Funk, Greco, Grünenfelder, Grünewald, Guirimand, Guo, Hagen, Hosur, Hosur, Jaeger, Kerrien, Klupp, Kobayashi, Kopp, Kopp, Kramer, Krautwald, Kshirsagar, Kulak, Langelier, Lawson, Lee, Leege, Lenk, Lin, Loomis, Loret, Lyman, López-Blanco, Lövheim, Marcoux, Marras, McDowall, Meckes, Mora, Murakami, Nagel, Nagel, Navlakha, Nourani, Nozawa, Orchard, Panagiotidis, Radtke, Ramisetty, Remmert, Reynolds, Rollenhagen, Roller, Roller, Rowles, Rozen, Saeed, Schnee, Sheaffer, Silva, Singh, Snijder, Snyder, Sprinzak, Stampfer, Stellberger, Stelzl, Sugimoto, Suzek, Szklarczyk, Taylor, The UniProt Consortium, Thomsen, To, Tomishima, Toropova, Trus, Trus, Uetz, Uetz, Villaveces, Vittone, Vizcaíno, Wills, Winterbach, Wnuk, Xenarios, Yang, Yeh, You, Yu, Zahiri, Zeev-Ben-Mordehai, Zhang, Zhou   +133 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Constraining Relativistic Bow Shock Properties in Rotation-Powered Millisecond Pulsar Binaries [PDF]

, 2017
Multiwavelength followup of unidentified Fermi sources has vastly expanded the number of known galactic-field "black widow" and "redback" millisecond pulsar binaries. Focusing on their rotation-powered state, we interpret the radio to X-ray phenomenology
Baring, Matthew G., Böttcher, Markus, Harding, Alice K., Venter, Christo, Wadiasingh, Zorawar   +4 more
core   +4 more sources

CLCC1 promotes membrane fusion during herpesvirus nuclear egress

ABSTRACT/SUMMARYHerpesviralesare an ancient viral order that infects species from mollusks to humans for life. During infection, these viruses translocate their large capsids from the nucleus to the cytoplasm independently from the canonical route through the nuclear pore. Instead, capsids dock at the inner nuclear membrane and bud into the perinuclear
Bing Dai, Lucas Polack, Adrian Sperl, Haley Dame, Tien Huynh, Chloe Deveney, Chanyoung Lee, John G. Doench, Ekaterina E. Heldwein   +8 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Refined Neutron-Star Mass Determinations for Six Eclipsing X-Ray Pulsar Binaries

, 2011
We present an improved method for determining the mass of neutron stars in eclipsing X-ray pulsar binaries and apply the method to six systems, namely Vela X-1, 4U 1538-52, SMC X-1, LMC X-4, Cen X-3, and Her X-1.
Bildsten, Charles D. Bailyn, Clark, Faulkner, Heemskerk, Ilovaisky, Jeffrey E. McClintock, Jerome A. Orosz, Kalogera, Kiziltan, Manuel A. P. Torres, Meredith L. Rawls, Michelle M. Buxton, Orosz, Orosz, Pojmansky, Rappaport, Reynolds, Reynolds, van Kerkwijk, van Kerkwijk, van Kerkwijk, van Paradijs, van Paradijs, Zhang, Zuiderwijk, Özel   +26 more
core   +1 more source