Results 131 to 140 of about 31,285 (260)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Photometry of the eclipsing cataclysmic variable SDSS J152419.33+220920.0

, 2013
Aims. We present new photometry of the faint and poorly studied cataclysmic variable SDSS J152419.33+220920.0, analyze its light curve and provide an accurate ephemeris for this system. Methods.
Echevarria, J., Hernandez-Santisteban, J. V., Michel, R.   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The \^G Search for Extraterrestrial Civilizations with Large Energy Supplies. IV. The Signatures and Information Content of Transiting Megastructures

, 2015
Arnold (2005), Forgan (2013), and Korpela et al. (2015) noted that planet-sized artificial structures could be discovered with Kepler as they transit their host star.
Cartier, Kimberly M. S., Ford, Eric B., Jontof-Hutter, Daniel, Wright, Jason T., Zhao, Ming   +4 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex. [PDF]

PLoS Pathog, 2023
Chen H, Lye MF, Gorgulla C, Ficarro SB, Cuny GD, Scott DA, Wu F, Rothlauf PW, Wang X, Fernandez R, Pesola JM, Draga S, Marto JA, Hogle JM, Arthanari H, Coen DM.   +15 more
europepmc   +1 more source

Technology assessment of future intercity passenger transporation systems. Volume 1: Summary report [PDF]

Technical, economic, environmental, and sociopolitical issues associated with future intercity transportation system options were assured. Technology assessment was used as a tool to assist in the identification of basic research and technology ...

core   +1 more source

Eclipse Timings of the LMXB XTE J1710-281: Orbital Period Glitches

, 2010
We present an X-ray eclipse timing analysis of the transient low mass X-ray binary XTE J1710-281. We report observations of 57 complete X-ray eclipses, made with the proportional counter array detectors aboard the RXTE satellite. Using the eclipse timing
Biswajit Paul, Bradt, Chetana Jain, Chou, Cominsky, Deeter, Galloway, Homer, Hurley, in't Zand, Jahoda, Jahoda, Jain, Jain, Lanza, Maeda, Markwardt, Markwardt, Oosterbroek, Parmar, Paul, Paul, Paul, Paul, Porquet, Rappaport, Ratti, Ruderman, Singh, Tauris, Wachter, White, Wolff, Wolff   +33 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source