Results 111 to 120 of about 1,436,031 (236)

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Cell Reports, 2015
Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway. Together, the conserved herpesvirus proteins pUL31 and pUL34 form the heterodimeric nuclear egress complex (NEC), which, in turn, mediates the formation of tight-fitting membrane vesicles ...
Zeev-Ben-Mordehai, Tzviya, Weberruss, Marion, Lorenz, Michael, Cheleski, Juliana, Hellberg, Teresa, Whittle, Cathy, El Omari, Kamel, Vasishtan, Daven, Dent, Kyle C., Harlos, Karl, Franzke, Kati, Hagen, Christoph, Klupp, Barbara G., Antonin, Wolfram, Mettenleiter, Thomas C., Gruenewald, Kay   +15 more
openaire   +5 more sources

A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication

Retrovirology, 2011
Background The Gag polyproteins play distinct roles during the replication cycle of retroviruses, hijacking many cellular machineries to fulfill them.
Coiffic Audrey, Giron Marie-Lou, Paris Joris, Tobaly-Tapiero Joelle, Renault Noémie, Roingeard Philippe, Saïb Ali   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes

Nature Communications
Herpesvirales are an ancient viral order that causes lifelong infections in species from mollusks to humans. They export their capsids from the nucleus to the cytoplasm by a noncanonical nuclear egress route that involves capsid budding at the inner ...
Bing Dai, Adrian W. Sperl, Lucas Polack, Isabel Mejia, Haley Dame, Tien Huynh, Chloe Deveney, Nathalie Lavoie, Chanyoung Lee, John G. Doench, Matthew D. Daugherty, Ekaterina E. Heldwein   +11 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Role of Kinases in VZV Nuclear Egress

, 2015
Like all Herpesviruses VZV expresses two conserved proteins forming the nuclear egress complex (NEC), namely ORF24p and ORF27p, respectively homologous to UL34 and UL31 in HSV-1.
Istaz, Bastienne, Blondeau, Caroline, Sadzot-Delvaux, Catherine, Colson, Catherine, Lebrun, Marielle, thiry, marc   +5 more
core  

Spanish Nuclear Safety Research under International Frameworks [PDF]

, 2013
The Nuclear Safety research requires a wide international collaboration of several involved groups. In this sense this paper pretends to show several examples of the Nuclear Safety research under international frameworks that is being performed in ...
Miró Herrero, Rafael, Queral, César, Raventós, Francesc, Ahnert, Carolina, Jiménez, Gonzalo, Gallardo Bermell, Sergio, Herranz. Luis Enrique, Verdú Martín, Gumersindo Jesús   +7 more
core   +1 more source