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Value of models for membrane budding [PDF]
Current Opinion in Cell Biology, 2021 The budding of membranes and curvature generation is common to many forms of trafficking in cells. Clathrin-mediated endocytosis, as a prototypical example of trafficking, has been studied in great detail using a variety of experimental systems and methods.
Padmini Rangamani +2 more
exaly +6 more sources
Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering [PDF]
mBio, 2021 During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is mediated by the viral nuclear egress complex (NEC) that deforms the membrane around the capsid by ...
Michael K. Thorsen +6 more
doaj +4 more sources
Cell, 2010 Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and enveloped virus release. These events range from those that are primarily protein driven, such as the formation of coated vesicles, to those that are primarily lipid driven, such as microdomain-dependent biogenesis of multivesicular bodies. Other types of budding
James Hurley +2 more
exaly +5 more sources
Programmable DNA shell scaffolds for directional membrane budding [PDF]
Nature CommunicationsIn the pursuit of replicating biological processes at the nanoscale, controlling cellular membrane dynamics has emerged as a key area of interest. Here, we report a system mimicking virus assembly to control directional membrane budding.
Michael T. Pinner, Hendrik Dietz
doaj +6 more sources
The Energy of COPI for Budding Membranes. [PDF]
PLoS ONE, 2015 As a major actor of cellular trafficking, COPI coat proteins assemble on membranes and locally bend them to bud 60 nm-size coated particles. Budding requires the energy of the coat assembly to overcome the one necessary to deform the membrane which ...
Abdou Rachid Thiam, Frédéric Pincet
doaj +4 more sources
The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice. [PDF]
PLoS PathogensNuclear egress is an essential process in herpesvirus replication whereby nascent capsids translocate from the nucleus to the cytoplasm. This initial step of nuclear egress-budding at the inner nuclear membrane-is coordinated by the nuclear egress ...
Elizabeth B Draganova +8 more
doaj +2 more sources
Endosomal membrane budding patterns in plants. [PDF]
Proc Natl Acad Sci U S AMultivesicular endosomes (MVEs) sequester membrane proteins destined for degradation within intralumenal vesicles (ILVs), a process mediated by the membrane-remodeling action of Endosomal Sorting Complex Required for Transport (ESCRT) proteins. In Arabidopsis , endosomal membrane constriction
Weiner E +7 more
europepmc +3 more sources
Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding [PDF]
eLife, 2017 The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers.
Manuel Alonso Y Adell +15 more
doaj +2 more sources
Molecular mechanics underlying flat-to-round membrane budding in live secretory cells [PDF]
Nature Communications, 2022 Shin et al. report the molecular mechanics of membrane budding: actin and dynamin pull membrane inward to form a Λ-shape profile; dynamin helices convert Λ- to Ω-shape by constricting Λ’s base, and then constrict Ω-profile’s pore to form a vesicle.
Wonchul Shin +11 more
doaj +2 more sources
Advanced Materials Interfaces, 2020 Membrane budding is an essential process during various biological activities, such as intercellular communication and transportation of life‐sustaining molecules and signals, which primarily occur with the aid of particular proteins.
Yeon Kyung Lee +3 more
doaj +2 more sources