Membrane budding is a major mechanism of in vivo platelet biogenesis. [PDF]
J Exp Med, 2020 How platelets are produced by megakaryocytes in vivo remains controversial despite more than a century of investigation. Megakaryocytes readily produce proplatelet structures in vitro; however, visualization of platelet release from proplatelets in vivo has remained elusive.
Potts KS +17 more
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Chemically Driven Division of Protocells by Membrane Budding. [PDF]
J Am Chem SocDivision is crucial for replicating biological compartments and, by extension, a fundamental aspect of life. Current studies highlight the importance of simple vesicular structures in prebiotic conditions, yet the mechanisms behind their self-division remain poorly understood.
Zambrano P +5 more
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Membrane transformations of fusion and budding
Nature CommunicationsMembrane fusion and budding mediate fundamental processes like intracellular trafficking, exocytosis, and endocytosis. Fusion is thought to open a nanometer-range pore that may subsequently close or dilate irreversibly, whereas budding transforms flat ...
Ling-Gang Wu, Chung Yu Chan
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The Mechanism of Budding of Retroviruses from Cell Membranes [PDF]
Advances in Virology, 2009 Retroviruses have evolved a mechanism for the release of particles from the cell membrane that appropriates cellular protein complexes, referred to as ESCRT-I, -II, -III, normally involved in the biogenesis of multivesicular bodies.
Andrew Pincetic, Jonathan Leis
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Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs [PDF]
Cell Reports, 2016 DYT1 dystonia is a neurodevelopmental disease that manifests during a discrete period of childhood. The disease is caused by impaired function of torsinA, a protein linked to nuclear membrane budding.
Lauren M. Tanabe +2 more
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Bud-neck scaffolding as a possible driving force in ESCRT-induced membrane budding. [PDF]
Biophys J, 2015 Membrane budding is essential for processes such as protein sorting and transport. Recent experimental results with ESCRT proteins reveal a novel budding mechanism, with proteins emerging in bud necks but separated from the entire bud surface.
Mercker M, Marciniak-Czochra A.
europepmc +4 more sources
Budding and Fission of Membrane Vesicles: A Mini Review
Frontiers in Physics, 2020 In this mini-review, a brief historical survey of the mechanisms which determine the shapes of liposomes and cells and the budding and fission of their membrane is presented.
Samo Penič +9 more
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Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response [PDF]
Advanced ScienceRadiotherapy failure often arises from tumor repopulation by treatment‐resistant cancer cells. Following irradiation, cancer cells can undergo endoreplication to form polyploid giant cancer cells (PGCCs)—radiation‐persistent cells capable of generating ...
Zheng Deng +20 more
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Clathrin mediates membrane fission and budding by constricting membrane pores
Cell DiscoveryMembrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, to form Ω-shape profiles and helix ...
Lisi Wei +23 more
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Herpes Simplex Virus 1 UL34 Mutants That Affect Membrane Budding Regulation and Nuclear Lamina Disruption [PDF]
Journal of Virology, 2021 Richard Roller
exaly +2 more sources