Results 101 to 110 of about 1,459,761 (217)

A Bound on the Energy Loss of Partons in Nuclei

, 1992
We derive a quantum mechanical upper bound on the amount of radiative energy loss suffered by high energy quarks and gluons in nuclear matter. The bound shows that the nuclear suppression observed in quarkonium production at high $x_F$ cannot be ...
Alde, Alde, Alde, Arvidson, Badier, Barton, Bertsch, Bodwin, Brodsky, Brodsky, Brodsky, Brodsky, Brodsky, Brodsky, Brodsky, Busza, Del Duca, Feinberg, Frankel, Frankfurt, Gavin, Good, Good, Gyulassy, Heiselberg, Hoyer, Hufner, Hufner, Katsanevas, Landau, Landau, Migdal, Mueller, Mueller, Paul Hoyer, Pomeranchuk, Quack, Ryan, Stanley J. Brodsky, Thoma, Vogt, Windmolders   +41 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effect of transparency on changing views regarding nuclear energy before and after Fukushima accident [PDF]

Using cross-country data, this paper examines the influence of government transparency on changing views regarding nuclear energy before and after Japan’s natural and nuclear disasters of 2011.
Yamamura, Eiji
core   +1 more source

Don’t Give up on Nuclear Energy [PDF]

, 2019
The nuclear power plant failures at Three Mile Island and Chernobyl in the late 1970s and 1980s split Americans into two passionate camps. For some, nuclear plants posed serious threats to both environmental and national security, and, for others ...
Gertner, Daniel
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Effect of Calcium Carbonate and Cholecalciferol on Pharmacokinetic Interaction of 99mTc-CTMP Radiopharmaceuticals for Bone Scanning in Rats (Rattus norvegicus)

Atom Indonesia, 2018
Hypocalcemia is one of manifestation of bone metastases which could be treated using calcium carbonate and cholecalciferol. Tc-99m radiolabeled 1,4,8,11-tetraazacyclo tetradecyl-1,4,8,11-tetramethylene phosponic acid(against 99mTc-CTMP)on the other hand
I. Mahendra, I. Daruwati, T. H. Ambarwibawa, W. Nuraeni   +3 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source