Results 101 to 110 of about 575,297 (245)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Investigation into the radioactivity of various natural and anthropogenic radionuclides in marine sediments from the Sudanese coastline of the Red Sea

Scientific Reports
A total of sixty surface sediment samples were systematically obtained from ten distinct locations along the Sudanese coastline of the Red Sea during the summer season (June 2016) and the winter season (February 2017), subsequently analyzed using high ...
Elshafeea Abowslama, Mohamed Eltayeb, Khalid Elmamoun Ibrahim, Tarig Elshaarani, Mossap Babikir, Ekrami Osman, Gosai Abdelgader, Nuha Tarig, Nasreen Hassan, Mashaer Khalied, Fatima Elbasheer, Mohammed AbdulRahman, Alfatih Osman   +12 more
doaj   +1 more source

Aspects of Applied Chemistry Related to Future Goals of Safety and Efficiency in Materials Development for Nuclear Energy. [PDF]

Molecules, 2023
Golgovici F, Tudose AE, Diniasi D, Nartita R, Fulger M, Demetrescu I.   +5 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Investigating the EKC hypothesis with renewable energy, nuclear energy, and R&D for EU: fresh panel evidence. [PDF]

Heliyon, 2022
Voumik LC, Rahman M, Akter S.
europepmc   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

APPLICATION OF IONIZING RADIATION IN THE PRESERVATION AND CONSERVATION OF TAXIDERMIED ANIMAL SKINS IN NATURAL HISTORY MUSEUMS

Brazilian Journal of Radiation Sciences
The great interest in the development of research involving ionizing radiation aims to significantly increase the conservation of the skins of taxidermized animals, both for scientific collections and on display, causing their infection and ...
Carmina Lupo, Maria José Alves de Oliveira, Mariana S. Araujo, Larissa Otubo, Sonia Mello Castanho, Pablo Antônio Salvador Vasquez   +5 more
doaj   +1 more source

Transmutation of long-lived fission products in an advanced nuclear energy system. [PDF]

Sci Rep, 2022
Sun XY, Luo W, Lan HY, Song YM, Gao QY, Zhu ZC, Chen JG, Cai XZ.   +7 more
europepmc   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Study of Degradation Mechanisms of Strength and Thermal-Physical Properties of Nitride and Carbide Ceramics-Promising Materials for Nuclear Energy. [PDF]

Nanomaterials (Basel), 2022
Berguzinov A, Kozlovskiy A, Kenzhina I, Shlimas DI.   +3 more
europepmc   +1 more source