Results 101 to 110 of about 1,461,012 (347)

Assessment of CTF boiling transition and critical heat flux modeling capabilities using the OECD/NRC BFBT and PSBT benchmark databases [PDF]

, 2011
The need to refine models for best-estimate calculations, based on good-quality experimental data, has been expressed in many recent meetings in the field of nuclear applications.
Avramova, Maria, Cuervo Gómez, Diana
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Physics and engineering of nuclear reactors at the "Ecole Nationale Supérieure de Physique de Grenoble" of the "Institut National Polytechnique de Grenoble"

, 2007
International audienceIf the use of fossil fuels is to be limited to curtail greenhouse gas emissions, fission nuclear energy is, along with new renewable energies, one of the primary energy sources able to respond significantly to the increasing ...
Brissot, R., Merle-Lucotte, E.
core   +1 more source

Motivating young students to be part of the global research in nuclear through the Seminar of Nuclear Fusion [PDF]

, 2013
Jóvenes Nucleares (Spanish Young Generation in Nuclear, JJNN) is a non-profit organization that depends on the Spanish Nuclear Society (SNE). The Universidad Politécnica de Madrid (Technical University of Madrid, UPM) was chosen to host the Seminar as ...
Barbas, A., Jiménez Varas, Gonzalo, Ochoa Valero, Raquel   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

NUCLEAR GAS ENGINE [PDF]

, 1958
A preliminary design study of the nuclear gas engine, consisting of a gas-cooled reactor directly coupled to a reciprocating engine, is presented. The principles of operation of the proposed gas engine are outlined and typical variations anre discussed. The nuclear gas engine is compared with other reciprocating engines and air compressors.
openaire   +2 more sources

Multi-Objective Design Optimization of the Leg Mechanism for a Piping Inspection Robot [PDF]

, 2014
This paper addresses the dimensional synthesis of an adaptive mechanism of contact points ie a leg mechanism of a piping inspection robot operating in an irradiated area as a nuclear power plant.
Boyer, Frédéric, Chablat, Damien, Henry, Renaud, Kanaan, Daniel, Porez, Mathieu   +4 more
core   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Editorial: CFD Applications in Nuclear Engineering

Frontiers in Energy Research, 2021
Wenxi Tian, Mingjun Wang, Victor Petrov, Nejdet Erkan, Yixiang Liao   +4 more
doaj   +1 more source

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]

, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
core   +1 more source