Results 111 to 120 of about 7,084,452 (309)
Simulation of an interacting system using a cellular automaton [PDF]
, 1987 Thesis (B.S.)--Massachusetts Institute of Technology, Dept.
Donis, Peter Andrew
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Effects of variation of uranium enrichment on nuclear submarine reactor design
, 1990 Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1990.Includes bibliographical references (leaves 181-186).by Thomas Dominic Ippolito, Jr.M ...
Ippolito, Thomas Dominic
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
A method for risk analysis of nuclear reactor accidents [PDF]
, 1978 Originally presented as the first author's thesis, (Ph. D.)--in the M.I.T. Dept. of Nuclear Engineering, 1976Includes bibliographical references (pages 207-208)Prepared for the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research no.
Vesely W. E. +2 more
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
, 1990 Thesis (Nucl. E.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1990.Includes bibliographical references (p.
Stewart, William A. (William Andrew)
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The ramifications of a delay in the national high-level waste repository program [PDF]
, 1988 Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1988.Includes bibliographical references (leaves 299-300).by Scott Alan Vance.M ...
Vance, Scott Alan
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source