Results 131 to 140 of about 7,084,452 (309)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Mixed convection and hydrodynamic modeling of flows in rod bundles
, 1984 Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1984.Bibliography: leaves 284-290.by Apostolos Efthimiadis.Ph.D.Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept.
Efthimiadis, Apostolos.
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Engineering coherent control of quantum information in spin systems [PDF]
, 2007 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2007.Includes bibliographical references (p. 151-161).Quantum Information Processing (QIP) promises increased efficiency in computation.
Hodges, Jonathan Stuart
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Mapping and analyzing nuclear weapons programs development
, 2020 Thesis: S.B., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, May, 2020Cataloged from the official PDF of thesis.Includes bibliographical references (pages 23-25).An in-depth review of the types of nuclear reactors ...
Strei, Thomas J.III.
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Fuel cycles in nuclear reactors [PDF]
, 1959 Series numbering from publisher's list"61"--stamped on cover"Unclassified. NYO-2131."Originally issued by the first author as an Sc. D. thesis, Massachusetts Institute of Technology, Dept.
Shanstrom, R. T. +2 more
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NUCLEAR POWER ENGINEERING IN THE WORLD AND UKRAINE
Elektrotehnìka ta Elektroenergetika, 2008 Анализируются состояние, перспективы развития в мире и Украине атомной энергетики на период до 2030 года. Сделаны выводы о жизнеспособности и перспективности атомной энергетики в большинстве стран.
I. G. Shirnin, V. A. Palkin
doaj
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source