Results 81 to 90 of about 688,071 (260)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Hydrodynamic Scaling Analysis of Nuclear Fusion driven by ultra-intense laser-plasma interactions

, 2012
We discuss scaling laws of fusion yields generated by laser-plasma interactions. The yields are found to scale as a function of the laser power. The origin of the scaling law in the laser driven fusion yield is derived in terms of hydrodynamic scaling ...
Bonasera, Aldo, Kimura, Sachie
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Upper Limit on the molecular resonance strengths in the ${}^{12}$C+${}^{12}$C fusion reaction

, 2011
Carbon burning is a crucial process for a number of important astrophysical scenarios. The lowest measured energy is around E$_{\rm c.m.}$=2.1 MeV, only partially overlapping with the energy range of astrophysical interest. The currently adopted reaction
B Bucher, Barnes C A, C J Lin, C L Jiang, Cooper R L, Greiner W, H Esbensen, K E Rehm, Keek L, X D Tang, X Fang, Zickefoose J   +11 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Low-energy (anti)neutrino physics with Borexino: Neutrinos from the primary proton-proton fusion process in the Sun

, 2014
The Sun is fueled by a series of nuclear reactions that produce the energy that makes it shine. The primary reaction is the fusion of two protons into a deuteron, a positron and a neutrino.
Avanzini, M., Bellini, G., Benziger, J., Bick, D., Bonfini, G., Bravo, D., Caccianiga, B., Cadonati, L., Calaprice, F., Carraro, C., Cavalcante, P., Chavarria, A., Chepurnov, A., Chubakov, V., D'Angelo, D., Davini, S., Derbin, A., Etenko, A., Fomenko, K., Franco, D., Galbiati, C., Gazzana, S., Ghiano, C., Giammarchi, M., Goretti, A., Grandi, L., Guardincerri, E., Göger-Neff, M., Hardy, S., Ianni, A., Ianni, A., Kobychev, V., Korablev, D., Korga, G., Koshio, Y., Kryn, D., Laubenstein, M., Lewke, T., Lissia, M., Litvinovich, E., Loer, B., Lombardi, F., Lombardi, P., Ludhova, L., Machulin, I., Manecki, S., Maneschg, W., Mantovani, F., Manuzio, G., Meindl, Q., Meroni, E., Miramonti, L., Misiaszek, M., Montanari, D., Mosteiro, P., Muratova, V., Nisi, S., Oberauer, L., Obolensky, M., Ortica, F., Otis, K., Pallavicini, M., Papp, L., Perasso, L., Perasso, S., Pocar, A., Ranucci, G., Razeto, A., Re, A., Romani, A., Rossi, N., Sabelnikov, A., Saldanha, R., Salvo, C., Schönert, S., Simgen, H., Skorokhvatov, M., Smirnov, O., Sotnikov, A., Sukhotin, S., Suvorov, Y., Tartaglia, R., Testera, G., Vogelaar, R., von Feilitzsch, F., Winter, J., Wojcik, M., Wright, A., Wurm, M., Xhixha, G., Xu, J., Zaimidoroga, O., Zavatarelli, S., Zuzel, G.   +93 more
core   +5 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Is Self-Interacting Dark Matter Undergoing Dark Fusion?

, 2017
We suggest that two-to-two dark matter fusion may be the relaxation process that resolves the small-scale structure problems of the cold collisionless dark matter paradigm.
McDermott, Samuel D.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source